Cover photograph (Copyright © 2005, American Society for Microbiology. All Rights Reserved.): In vitro cyst containing immature bradyzoites of the Toxoplasma gondii Prugniaud strain, which express a transgenic yellow fluorescent protein targeted to micronemes (apical secretory organelles). The immature cyst wall is stained with tetramethylrhodamine isothiocyanate-labeled Dolichos biflorus lectin, and endogenous microneme protein MIC3 is detected with monoclonal anti-MIC3 antibody (kindly provided by J. F. Dubremetz, University of Montpellier, Montpellier, France) and AlexaFluor 350-conjugated goat anti-mouse immunoglobulin G antiserum (Molecular Probes). (Photo courtesy of F. Dzierszinski and D. S. Roos, University of Pennsylvania, Philadelphia, Pa.) (See related article in the December 2004 issue: vol. 72, p. 7240.)