Cover photograph (Copyright © 2005, American Society for Microbiology. All Rights Reserved.): Three formalin-fixed spherules of Coccidioides posadasii surrounded by RAW macrophages transfected to overexpress dectin-1 and stained with Gomori methenamine silver. Magnification, × 1,000. (Photo courtesy of Maria del Pilar Jimenez-Alzate.) (See related article on page 1553.)