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Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): Enteropathogenic Escherichia coli (EPEC) recruits zonula occludens-1, a tight junction scaffold protein, to the bacterium-created actin-rich structures termed pedestals. Shown are the pedestals stained to reveal EPEC cells (blue), actin bundles (red), and zonula occludens-1 (green) in EPEC-infected HeLa cells. It is notable that zonula occludens-1 is stained most in the distal part of the structures, suggesting that a certain factor(s) at the region mediates the particular localization. (See related article in the February 2007 issue: vol. 75, page 565.)
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