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Spotlight:

Articles of Significant Interest Selected from This Issue by the Editors
Infect. Immun. 2008 76: 2257-2258. [Full Text] [PDF] [Reprints and Permissions]  

Minireviews:

Bryan P. Hurley and Beth A. McCormick

Multiple Roles of Phospholipase A₂ during Lung Infection and Inflammation
Infect. Immun. 2008 76: 2259-2272. [Full Text] [PDF] [Reprints and Permissions]  

Molecular Pathogenesis:

John H. Carlson, William M. Whitmire, Deborah D. Crane, Luke Wicke, Kimmo Virtaneva, Daniel E. Sturdevant, John J. Kupko, III, Stephen F. Porcella, Neysha Martinez-Orengo, Robert A. Heinzen, Laszlo Kari, and Harlan D. Caldwell

The Chlamydia trachomatis Plasmid Is a Transcriptional Regulator of Chromosomal Genes and a Virulence Factor
Infect. Immun. 2008 76: 2273-2283. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Falk F. R. Buettner, Ibrahim M. Bendallah, Janine T. Bosse, Karla Dreckmann, John H. E. Nash, Paul R. Langford, and Gerald-F. Gerlach

Analysis of the Actinobacillus pleuropneumoniae ArcA Regulon Identifies Fumarate Reductase as a Determinant of Virulence
Infect. Immun. 2008 76: 2284-2295. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Paula J. Crowley, Trevor B. Seifert, Ryutaro Isoda, Marloes van Tilburg, Monika W. Oli, Rebekah A. Robinette, William P. McArthur, Arnold S. Bleiweis, and L. Jeannine Brady

Requirements for Surface Expression and Function of Adhesin P1 from Streptococcus mutans
Infect. Immun. 2008 76: 2456-2468. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Robert M. Q. Shanks, Michael A. Meehl, Kimberly M. Brothers, Raquel M. Martinez, Niles P. Donegan, Martha L. Graber, Ambrose L. Cheung, and George A. O'Toole

Genetic Evidence for an Alternative Citrate-Dependent Biofilm Formation Pathway in Staphylococcus aureus That Is Dependent on Fibronectin Binding Proteins and the GraRS Two-Component Regulatory System
Infect. Immun. 2008 76: 2469-2477. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hema M. Vasudeva-Rao and Kathleen A. McDonough

Expression of the Mycobacterium tuberculosis acr-Coregulated Genes from the DevR (DosR) Regulon Is Controlled by Multiple Levels of Regulation
Infect. Immun. 2008 76: 2478-2489. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Feng Luo, Sergio Lizano, and Debra E. Bessen

Heterogeneity in the Polarity of Nra Regulatory Effects on Streptococcal Pilus Gene Transcription and Virulence
Infect. Immun. 2008 76: 2490-2497. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Jessica L. Hughes, Christi L. Nolder, Andrew J. Nowalk, Dawn R. Clifton, Rebekah R. Howison, Virginia L. Schmit, Robert D. Gilmore, Jr., and James A. Carroll

Borrelia burgdorferi Surface-Localized Proteins Expressed during Persistent Murine Infection Are Conserved among Diverse Borrelia spp.
Infect. Immun. 2008 76: 2498-2511. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

John F. Teiber, Sven Horke, Donovan C. Haines, Puneet K. Chowdhary, Junhui Xiao, Gerald L. Kramer, Robert W. Haley, and Dragomir I. Draganov

Dominant Role of Paraoxonases in Inactivation of the Pseudomonas aeruginosa Quorum-Sensing Signal N-(3-Oxododecanoyl)-L-Homoserine Lactone
Infect. Immun. 2008 76: 2512-2519. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ahmed S. Attia, Jennifer L. Sedillo, Wei Wang, Wei Liu, Chad A. Brautigam, Wade Winkler, and Eric J. Hansen

Moraxella catarrhalis Expresses an Unusual Hfq Protein
Infect. Immun. 2008 76: 2520-2530. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jason W. Rosch, Luis Alberto Vega, John M. Beyer, Ada Lin, and Michael G. Caparon

The Signal Recognition Particle Pathway Is Required for Virulence in Streptococcus pyogenes
Infect. Immun. 2008 76: 2612-2619. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ling Li, Jessica L. Rock, and David R. Nelson

Identification and Characterization of a Repeat-in-Toxin Gene Cluster in Vibrio anguillarum
Infect. Immun. 2008 76: 2620-2632. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions:

Hirosato Mashima, Junko Suzuki, Toshiya Hirayama, Yukako Yoshikumi, Hideki Ohno, Hirohide Ohnishi, Hiroshi Yasuda, Toshiro Fujita, and Masao Omata

Involvement of Vesicle-Associated Membrane Protein 7 in Human Gastric Epithelial Cell Vacuolation Induced by Helicobacter pylori-Produced VacA
Infect. Immun. 2008 76: 2296-2303. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yoshiaki Hasegawa, Gena D. Tribble, Henry V. Baker, Jeffrey J. Mans, Martin Handfield, and Richard J. Lamont

Role of Porphyromonas gingivalis SerB in Gingival Epithelial Cell Cytoskeletal Remodeling and Cytokine Production
Infect. Immun. 2008 76: 2420-2427. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Carolina Verónica Poncini, Catalina Dirney Alba Soto, Estela Batalla, Maria Elisa Solana, and Stella Maris González Cappa

Trypanosoma cruzi Induces Regulatory Dendritic Cells In Vitro
Infect. Immun. 2008 76: 2633-2641. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Pricila Hauk, Felipe Macedo, Eliete Caló Romero, Sílvio Arruda Vasconcellos, Zenaide Maria de Morais, Angela Silva Barbosa, and Paulo Lee Ho

In LipL32, the Major Leptospiral Lipoprotein, the C Terminus Is the Primary Immunogenic Domain and Mediates Interaction with Collagen IV and Plasma Fibronectin
Infect. Immun. 2008 76: 2642-2650. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marina Santic, Rexford Asare, Ivana Skrobonja, Snake Jones, and Yousef Abu Kwaik

Acquisition of the Vacuolar ATPase Proton Pump and Phagosome Acidification Are Essential for Escape of Francisella tularensis into the Macrophage Cytosol
Infect. Immun. 2008 76: 2671-2677. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Heather L. Howie, Shelly L. Shiflett, and Magdalene So

Extracellular Signal-Regulated Kinase Activation by Neisseria gonorrhoeae Downregulates Epithelial Cell Proapoptotic Proteins Bad and Bim
Infect. Immun. 2008 76: 2715-2721. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Julie A. Wasylnka, Malina A. Bakowski, Jason Szeto, Maikke B. Ohlson, William S. Trimble, Samuel I. Miller, and John H. Brumell

Role for Myosin II in Regulating Positioning of Salmonella-Containing Vacuoles and Intracellular Replication
Infect. Immun. 2008 76: 2722-2735. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Zhongyu Li, Chaoqun Chen, Ding Chen, Yimou Wu, Youmin Zhong, and Guangming Zhong

Characterization of Fifty Putative Inclusion Membrane Proteins Encoded in the Chlamydia trachomatis Genome
Infect. Immun. 2008 76: 2746-2757. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Bacterial Infections:

Adam C. Rupper and James A. Cardelli

Induction of Guanylate Binding Protein 5 by Gamma Interferon Increases Susceptibility to Salmonella enterica Serovar Typhimurium-Induced Pyroptosis in RAW 264.7 Cells
Infect. Immun. 2008 76: 2304-2315. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Gaoyan Tang, Todd Kitten, Cindy L. Munro, George C. Wellman, and Keith P. Mintz

EmaA, a Potential Virulence Determinant of Aggregatibacter actinomycetemcomitans in Infective Endocarditis
Infect. Immun. 2008 76: 2316-2324. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Yuanlin Song, Jean Francois Pittet, Xiaozhu Huang, Hong He, Susan V. Lynch, Shelia M. Violette, Paul H. Weinreb, Gerald S. Horan, Amua Carmago, Yoriko Sawa, Xin Liu Bernstein, and Jeanine P. Wiener-Kronish

Role of Integrin vβ6 in Acute Lung Injury Induced by Pseudomonas aeruginosa
Infect. Immun. 2008 76: 2325-2332. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Laura E. Via, P. Ling Lin, Sonja M. Ray, Jose Carrillo, Shannon Sedberry Allen, Seok Yong Eum, Kimberly Taylor, Edwin Klein, Ujjini Manjunatha, Jacqueline Gonzales, Eun Gae Lee, Seung Kyu Park, James A. Raleigh, Sang Nae Cho, David N. McMurray, JoAnne L. Flynn, and Clifton E. Barry, III

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates
Infect. Immun. 2008 76: 2333-2340. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Hye-Kyoung Jun, Young-Mi Kang, Hae-Ri Lee, Sung-Hoon Lee, and Bong-Kyu Choi

Highly Conserved Surface Proteins of Oral Spirochetes as Adhesins and Potent Inducers of Proinflammatory and Osteoclastogenic Factors
Infect. Immun. 2008 76: 2428-2438. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Shari A. Jones, Mathias Jorgensen, Fatema Z. Chowdhury, Rosalie Rodgers, James Hartline, Mary P. Leatham, Carsten Struve, Karen A. Krogfelt, Paul S. Cohen, and Tyrrell Conway

Glycogen and Maltose Utilization by Escherichia coli O157:H7 in the Mouse Intestine
Infect. Immun. 2008 76: 2531-2540. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Xiuchun Ge, Todd Kitten, Zhenming Chen, Sehmi P. Lee, Cindy L. Munro, and Ping Xu

Identification of Streptococcus sanguinis Genes Required for Biofilm Formation and Examination of Their Role in Endocarditis Virulence
Infect. Immun. 2008 76: 2551-2559. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Torsten G. Loof, Oliver Goldmann, and Eva Medina

Immune Recognition of Streptococcus pyogenes by Dendritic Cells
Infect. Immun. 2008 76: 2785-2792. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Navit Grinberg, Sharon Elazar, Ilan Rosenshine, and Nahum Y. Shpigel

β-Hydroxybutyrate Abrogates Formation of Bovine Neutrophil Extracellular Traps and Bactericidal Activity against Mammary Pathogenic Escherichia coli
Infect. Immun. 2008 76: 2802-2807. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Host Response and Inflammation:

Ok S. Shin, Ralph R. Isberg, Shizuo Akira, Satoshi Uematsu, Aruna K. Behera, and Linden T. Hu

Distinct Roles for MyD88 and Toll-Like Receptors 2, 5, and 9 in Phagocytosis of Borrelia burgdorferi and Cytokine Induction
Infect. Immun. 2008 76: 2341-2351. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Anne Rosbottom, E. Helen Gibney, Catherine S. Guy, Anja Kipar, Robert F. Smith, Pete Kaiser, Alexander J. Trees, and Diana J. L. Williams

Upregulation of Cytokines Is Detected in the Placentas of Cattle Infected with Neospora caninum and Is More Marked Early in Gestation When Fetal Death Is Observed
Infect. Immun. 2008 76: 2352-2361. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Julia F. Charles, Mary Beth Humphrey, Xiaodan Zhao, Ellen Quarles, Mary C. Nakamura, Alan Aderem, William E. Seaman, and Kelly D. Smith

The Innate Immune Response to Salmonella enterica Serovar Typhimurium by Macrophages Is Dependent on TREM2-DAP12
Infect. Immun. 2008 76: 2439-2447. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Zhiyong Ye, Cheryl Mei Ling Lee, Guang Wen Sun, and Yunn-Hwen Gan

Burkholderia pseudomallei Infection of T Cells Leads to T-Cell Costimulation Partially Provided by Flagellin
Infect. Immun. 2008 76: 2541-2550. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Matthew D. Woolard, Lucinda L. Hensley, Thomas H. Kawula, and Jeffrey A. Frelinger

Respiratory Francisella tularensis Live Vaccine Strain Infection Induces Th17 Cells and Prostaglandin E₂, Which Inhibits Generation of Gamma Interferon-Positive T Cells
Infect. Immun. 2008 76: 2651-2659. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Krzysztof Trzcinski, Claudette M. Thompson, Amit Srivastava, Alan Basset, Richard Malley, and Marc Lipsitch

Protection against Nasopharyngeal Colonization by Streptococcus pneumoniae Is Mediated by Antigen-Specific CD4⁺ T Cells
Infect. Immun. 2008 76: 2678-2684. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Reidun Øvstebø, Ole Kristoffer Olstad, Berit Brusletto, Anne Sophie Møller, Audun Aase, Kari Bente Foss Haug, Petter Brandtzaeg, and Peter Kierulf

Identification of Genes Particularly Sensitive to Lipopolysaccharide (LPS) in Human Monocytes Induced by Wild-Type versus LPS-Deficient Neisseria meningitidis Strains
Infect. Immun. 2008 76: 2685-2695. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Francisco Airton Castro Rocha, Ana Karine Rocha Melo Leite, Margarida Maria Lima Pompeu, Thiago Mattar Cunha, Waldiceu A. Verri, Jr., Fernanda Macedo Soares, Rondinelle Ribeiro Castro, and Fernando Queiroz Cunha

Protective Effect of an Extract from Ascaris suum in Experimental Arthritis Models
Infect. Immun. 2008 76: 2736-2745. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Claude M. Nagamine, Jane J. Sohn, Barry H. Rickman, Arlin B. Rogers, James G. Fox, and David B. Schauer

Helicobacter hepaticus Infection Promotes Colon Tumorigenesis in the BALB/c-Rag2^–/– Apc^Min/+ Mouse
Infect. Immun. 2008 76: 2758-2766. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Fungal and Parasitic Infections:

Jennifer M. Dan, Ryan M. Kelly, Chrono K. Lee, and Stuart M. Levitz

Role of the Mannose Receptor in a Murine Model of Cryptococcus neoformans Infection
Infect. Immun. 2008 76: 2362-2367. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Shubhra Majumder and Anuradha Lohia

Entamoeba histolytica Encodes Unique Formins, a Subset of Which Regulates DNA Content and Cell Division
Infect. Immun. 2008 76: 2368-2378. [Abstract] [Full Text] [PDF] [Supplemental material] [Reprints and Permissions]  

Gwo-hsiao Chen, David A. McNamara, Yadira Hernandez, Gary B. Huffnagle, Galen B. Toews, and Michal A. Olszewski

Inheritance of Immune Polarization Patterns Is Linked to Resistance versus Susceptibility to Cryptococcus neoformans in a Mouse Model
Infect. Immun. 2008 76: 2379-2391. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Jeroen P. J. Saeij, Gustavo Arrizabalaga, and John C. Boothroyd

A Cluster of Four Surface Antigen Genes Specifically Expressed in Bradyzoites, SAG2CDXY, Plays an Important Role in Toxoplasma gondii Persistence
Infect. Immun. 2008 76: 2402-2410. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Blaise Dondji, Richard D. Bungiro, Lisa M. Harrison, Jon J. Vermeire, Carlo Bifulco, Diane McMahon-Pratt, and Michael Cappello

Role for Nitric Oxide in Hookworm-Associated Immune Suppression
Infect. Immun. 2008 76: 2560-2567. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Edmond J. Remarque, Bart W. Faber, Clemens H. M. Kocken, and Alan W. Thomas

A Diversity-Covering Approach to Immunization with Plasmodium falciparum Apical Membrane Antigen 1 Induces Broader Allelic Recognition and Growth Inhibition Responses in Rabbits
Infect. Immun. 2008 76: 2660-2670. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ying-Lien Chen, Sarah Kauffman, and Todd B. Reynolds

Candida albicans Uses Multiple Mechanisms To Acquire the Essential Metabolite Inositol during Infection
Infect. Immun. 2008 76: 2793-2801. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Microbial Immunity and Vaccines:

Xiaozhou Jiang, Caixia Shen, Jose Rey-Ladino, Hong Yu, and Robert C. Brunham

Characterization of Murine Dendritic Cell Line JAWS II and Primary Bone Marrow-Derived Dendritic Cells in Chlamydia muridarum Antigen Presentation and Induction of Protective Immunity
Infect. Immun. 2008 76: 2392-2401. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Angela M. Arenas-Gamboa, Thomas A. Ficht, Melissa M. Kahl-McDonagh, and Allison C. Rice-Ficht

Immunization with a Single Dose of a Microencapsulated Brucella melitensis Mutant Enhances Protection against Wild-Type Challenge
Infect. Immun. 2008 76: 2448-2455. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Peter T. Beernink and Dan M. Granoff

Bactericidal Antibody Responses Induced by Meningococcal Recombinant Chimeric Factor H-Binding Protein Vaccines
Infect. Immun. 2008 76: 2568-2575. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Asim A. Siddiqui, Hema Bora, Neeru Singh, Aditya P. Dash, and Yagya D. Sharma

Expression, Purification, and Characterization of the Immunological Response to a 40-Kilodalton Plasmodium vivax Tryptophan-Rich Antigen
Infect. Immun. 2008 76: 2576-2586. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Ryan W. Honaker, Amanda Stewart, Stephanie Schittone, Angelo Izzo, Michèl R. Klein, and Martin I. Voskuil

Mycobacterium bovis BCG Vaccine Strains Lack narK2 and narX Induction and Exhibit Altered Phenotypes during Dormancy
Infect. Immun. 2008 76: 2587-2593. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Tom N. McNeilly, Stuart W. Naylor, Arvind Mahajan, Mairi C. Mitchell, Sean McAteer, David Deane, David G. E. Smith, J. Christopher Low, David L. Gally, and John F. Huntley

Escherichia coli O157:H7 Colonization in Cattle following Systemic and Mucosal Immunization with Purified H7 Flagellin
Infect. Immun. 2008 76: 2594-2602. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Christine A. Shaw and Michael N. Starnbach

Both CD4⁺ and CD8⁺ T Cells Respond to Antigens Fused to Anthrax Lethal Toxin
Infect. Immun. 2008 76: 2603-2611. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Marcela Medina, Julio Villena, Elisa Vintiñi, Elvira María Hebert, Raúl Raya, and Susana Alvarez

Nasal Immunization with Lactococcus lactis Expressing the Pneumococcal Protective Protein A Induces Protective Immunity in Mice
Infect. Immun. 2008 76: 2696-2705. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Lasse S. Vestergaard, John P. Lusingu, Morten A. Nielsen, Bruno P. Mmbando, Daniel Dodoo, Bartholomew D. Akanmori, Michael Alifrangis, Ib C. Bygbjerg, Martha M. Lemnge, Trine Staalsoe, Lars Hviid, and Thor G. Theander

Differences in Human Antibody Reactivity to Plasmodium falciparum Variant Surface Antigens Are Dependent on Age and Malaria Transmission Intensity in Northeastern Tanzania
Infect. Immun. 2008 76: 2706-2714. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

David T. Glover, Susan K. Hollingshead, and David E. Briles

Streptococcus pneumoniae Surface Protein PcpA Elicits Protection against Lung Infection and Fatal Sepsis
Infect. Immun. 2008 76: 2767-2776. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Fumiki Momoi, Tomomi Hashizume, Tomoko Kurita-Ochiai, Yoshikazu Yuki, Hiroshi Kiyono, and Masafumi Yamamoto

Nasal Vaccination with the 40-Kilodalton Outer Membrane Protein of Porphyromonas gingivalis and a Nontoxic Chimeric Enterotoxin Adjuvant Induces Long-Term Protective Immunity with Reduced Levels of Immunoglobulin E Antibodies
Infect. Immun. 2008 76: 2777-2784. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Molecular Genomics:

Jin-Hong Qin, Qing Zhang, Zhi-Ming Zhang, Yi Zhong, Yang Yang, Bao-Yu Hu, Guo-Ping Zhao, and Xiao-Kui Guo

Identification of a Novel Prophage-Like Gene Cluster Actively Expressed in Both Virulent and Avirulent Strains of Leptospira interrogans Serovar Lai
Infect. Immun. 2008 76: 2411-2419. [Abstract] [Full Text] [PDF] [Reprints and Permissions]  

Letter To The Editor:

James G. Beeson, SubbaRao V. Madhunapantula, Rajeshwara N. Achur, and D. Channe Gowda

Characteristics of Plasmodium falciparum-Infected-Erythrocyte Adhesion to Chondroitin Sulfate
Infect. Immun. 2008 76: 2808-2809. [Full Text] [PDF] [Reprints and Permissions]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.