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Research Article

Murine macrophage activation by staphylococcal exotoxins.

S D Fleming, J J Iandolo, S K Chapes
S D Fleming
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J J Iandolo
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S K Chapes
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ABSTRACT

We investigated the ability of staphylococcal enterotoxins A and B, exfoliative toxins A and B, and toxic shock syndrome toxin 1 to activate macrophages. All of the toxins tested had the potential to stimulate tumoricidal activity in peritoneal macrophages from lipopolysaccharide-responsive C3HeB/FeJ mice. In contrast, none of the toxins activated cytotoxicity in lipopolysaccharide-unresponsive macrophages from C3H/HeJ mice. We also studied toxin stimulation of monokine secretion. Staphylococcal enterotoxin A, toxic shock syndrome toxin 1, and both exfoliative toxins triggered C3HeB/FeJ macrophages to secrete tumor necrosis factor alpha, but enterotoxin B induced only marginal amounts of tumor necrosis factor. All of the toxins used stimulated interleukin-6 production by macrophages from both strains of mice. Nitric oxide is produced in response to the exfoliative toxins only by the lipopolysaccharide-responsive macrophages. These results suggest that macrophages respond differently to several staphylococcal exotoxins.

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Murine macrophage activation by staphylococcal exotoxins.
S D Fleming, J J Iandolo, S K Chapes
Infection and Immunity Nov 1991, 59 (11) 4049-4055; DOI:

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Murine macrophage activation by staphylococcal exotoxins.
S D Fleming, J J Iandolo, S K Chapes
Infection and Immunity Nov 1991, 59 (11) 4049-4055; DOI:
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