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Journal Article | Research Support, Non-U.S. Gov't

Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis.

P Moreillon, J M Entenza, P Francioli, D McDevitt, T J Foster, P François, P Vaudaux
P Moreillon
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J M Entenza
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P Francioli
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D McDevitt
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T J Foster
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P François
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P Vaudaux
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ABSTRACT

The pathogenic role of staphylococcal coagulase and clumping factor was investigated in the rat model of endocarditis. The coagulase-producing and clumping factor-producing parent strain Staphylococcus aureus Newman and a series of mutants defective in either coagulase, clumping factor, or both were tested for their ability (i) to attach in vitro to either rat fibrinogen or platelet-fibrin clots and (ii) to produce endocarditis in rats with catheter-induced aortic vegetations. In vitro, the clumping factor-defective mutants were up to 100 times less able than the wild type strain to attach to fibrinogen and also significantly less adherent than the parents to platelet-fibrin clots. Coagulase-defective mutants, in contrast, were not altered in their in vitro adherence phenotype. The rate of in vivo infection was inoculum dependent. Clumping factor-defective mutants produced ca. 50% less endocarditis than the parent organisms when injected at inoculum sizes infecting, respectively, 40 and 80% (ID40 and ID80, respectively) of rats with the wild-type strain. This was a trend at the ID40 but was statistically significant at the ID80 (P < 0.05). Coagulase-defective bacteria were not affected in their infectivity. Complementation of a clumping factor-defective mutant with a copy of the wild-type clumping factor gene restored both its in vitro adherence and its in vivo infectivity. These results show that clumping factor plays a specific role in the pathogenesis of S. aureus endocarditis. Nevertheless, the rate of endocarditis with clumping factor-defective mutants increased with larger inocula, indicating the contribution of additional pathogenic determinants in the infective process.

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Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis.
P Moreillon, J M Entenza, P Francioli, D McDevitt, T J Foster, P François, P Vaudaux
Infection and Immunity Dec 1995, 63 (12) 4738-4743; DOI:

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Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis.
P Moreillon, J M Entenza, P Francioli, D McDevitt, T J Foster, P François, P Vaudaux
Infection and Immunity Dec 1995, 63 (12) 4738-4743; DOI:
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