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Journal Article | Research Support, U.S. Gov't, P.H.S.

Antibody response of the mouse reservoir of Borrelia burgdorferi in nature.

L R Brunet, C Sellitto, A Spielman, S R Telford 3rd
L R Brunet
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C Sellitto
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A Spielman
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S R Telford 3rd
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ABSTRACT

To determine whether the white-footed mouse reservoir host (Peromyscus leucopus) of the agent of Lyme disease (Borrelia burgdorferi) naturally mounts an immune response against the full range of antigens expressed by this zoonotic pathogen, we analyzed the pattern of immunoreactivity of these rodents at sites in which the intensity of transmission differs. Although the incidence of seroconversion within the reservoir population relates proportionally to the density of subadult deer ticks (Ixodes dammini), seroprevalence appears constant. About a fifth as many juvenile mice recognize spirachete antigens as do adult mice. Virtually all reservoir mice in nature recognize the p20, p35.5, p39, and p58 antigens, regardless of the intensity of transmission. Seropositive mice retain reactivity to a wide range of spirochetal antigens. Few mice recognize flagellin, OspB, and OspC. Although a third of serum samples include reactivity to a 31-kDa band, this reaction is irregular and may represent an uncharacterized antigen that comigrates with OspA. Mice captured where transmission is intense recognize the same spectrum of antigens as do mice captured where vector ticks are scarce.

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Antibody response of the mouse reservoir of Borrelia burgdorferi in nature.
L R Brunet, C Sellitto, A Spielman, S R Telford 3rd
Infection and Immunity Aug 1995, 63 (8) 3030-3036; DOI:

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Antibody response of the mouse reservoir of Borrelia burgdorferi in nature.
L R Brunet, C Sellitto, A Spielman, S R Telford 3rd
Infection and Immunity Aug 1995, 63 (8) 3030-3036; DOI:
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