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Journal Article | Research Support, Non-U.S. Gov't

CD4+ T-helper-cell responses in mice with low-level Candida albicans infection.

A Mencacci, R Spaccapelo, G Del Sero, K H Enssle, A Cassone, F Bistoni, L Romani
A Mencacci
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
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R Spaccapelo
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
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G Del Sero
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
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K H Enssle
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
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A Cassone
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
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F Bistoni
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
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L Romani
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
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ABSTRACT

Resistance and susceptibility to Candida albicans infection have been shown to be dependent upon the activation of CD4+ T helper (Th) type 1 or Th2 cells, respectively. To study the type, kinetics, and cytokine dependency of CD4+ Th-cell responses in low-level C. albicans infection, susceptible mice were infected with sublethal doses of C. albicans and assessed for parameters of CD4+ Th-dependent immunity. Interleukin (IL)-12 and gamma interferon were always produced early in infection regardless of the pathogen load. In contrast, production of IL-4, and hence Th2-cell reactivity, was strictly dose dependent, being induced at the higher dose of the fungus. Production of IL-12 correlated with a successful control of infection in mice exposed to the lower doses of C. albicans but not with the development of acquired immunity. An antigenic stimulus appeared to be required for IL-12 to induce a protective anticandidal response. Cytokine depletion in vivo revealed that neutralization of IL-4 was protective early but not late in infection, suggesting a different role for IL-4 in the induction versus maintenance of an ongoing anticandidal Th response. Late in infection, an exacerbative effect was also observed upon IL-12 neutralization. These results indicate that the fungal burden and timing of cytokine appearance greatly influence CD4+ Th induction and effector functions in mice with candidiasis.

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CD4+ T-helper-cell responses in mice with low-level Candida albicans infection.
A Mencacci, R Spaccapelo, G Del Sero, K H Enssle, A Cassone, F Bistoni, L Romani
Infection and Immunity Dec 1996, 64 (12) 4907-4914; DOI:

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CD4+ T-helper-cell responses in mice with low-level Candida albicans infection.
A Mencacci, R Spaccapelo, G Del Sero, K H Enssle, A Cassone, F Bistoni, L Romani
Infection and Immunity Dec 1996, 64 (12) 4907-4914; DOI:
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