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Journal Article | Research Support, Non-U.S. Gov't

Platelet-activating-factor-mediated pathogenesis in Lyme disease.

E Isogai, K Kimura, N Fujii, T Nishikawa, N Ishii, D Postic, G Baranton, H Isogai
E Isogai
Department of Preventive Dentistry, Health Sciences University of Hokkaido, Japan.
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K Kimura
Department of Preventive Dentistry, Health Sciences University of Hokkaido, Japan.
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N Fujii
Department of Preventive Dentistry, Health Sciences University of Hokkaido, Japan.
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T Nishikawa
Department of Preventive Dentistry, Health Sciences University of Hokkaido, Japan.
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N Ishii
Department of Preventive Dentistry, Health Sciences University of Hokkaido, Japan.
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D Postic
Department of Preventive Dentistry, Health Sciences University of Hokkaido, Japan.
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G Baranton
Department of Preventive Dentistry, Health Sciences University of Hokkaido, Japan.
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H Isogai
Department of Preventive Dentistry, Health Sciences University of Hokkaido, Japan.
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ABSTRACT

This study describes a role of platelet-activating factor (PAF) as a potential inducer of inflammation in infection with Borrelia burgdorferi. Two approaches were taken. The first involved the use of a PAF antagonist to show the lack of an inflammatory response in skin lesions. The second was to show that the PAF antagonist reduced platelet aggregation when the spirochetes were incubated with polymorphonuclear leukocytes.

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Platelet-activating-factor-mediated pathogenesis in Lyme disease.
E Isogai, K Kimura, N Fujii, T Nishikawa, N Ishii, D Postic, G Baranton, H Isogai
Infection and Immunity Mar 1996, 64 (3) 1026-1029; DOI:

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Platelet-activating-factor-mediated pathogenesis in Lyme disease.
E Isogai, K Kimura, N Fujii, T Nishikawa, N Ishii, D Postic, G Baranton, H Isogai
Infection and Immunity Mar 1996, 64 (3) 1026-1029; DOI:
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