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Journal Article | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S.

Lesions of primary and secondary syphilis contain activated cytolytic T cells.

W C van Voorhis, L K Barrett, J M Nasio, F A Plummer, S A Lukehart
W C van Voorhis
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98195, USA.
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L K Barrett
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98195, USA.
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J M Nasio
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98195, USA.
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F A Plummer
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98195, USA.
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S A Lukehart
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, 98195, USA.
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ABSTRACT

This study demonstrates that CD8+ cytotoxic lymphocytes (CTL) are found in both primary and secondary syphilis lesions. CD8+ T cells were detected by immunohistology, and mRNAs for granzyme B and perforin were detected by reverse transcription and PCR, suggesting that CD8+ cytotoxic lymphocytes are activated.

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Lesions of primary and secondary syphilis contain activated cytolytic T cells.
W C van Voorhis, L K Barrett, J M Nasio, F A Plummer, S A Lukehart
Infection and Immunity Mar 1996, 64 (3) 1048-1050; DOI:

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Lesions of primary and secondary syphilis contain activated cytolytic T cells.
W C van Voorhis, L K Barrett, J M Nasio, F A Plummer, S A Lukehart
Infection and Immunity Mar 1996, 64 (3) 1048-1050; DOI:
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