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Journal Article

Antibodies to Haemophilus influenzae type b polysaccharide affect bacterial adherence and multiplication.

L van Alphen, P Eijk, H Käyhty, J van Marle, J Dankert
L van Alphen
Department of Medical Microbiology, University of Amsterdam, The Netherlands.
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P Eijk
Department of Medical Microbiology, University of Amsterdam, The Netherlands.
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H Käyhty
Department of Medical Microbiology, University of Amsterdam, The Netherlands.
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J van Marle
Department of Medical Microbiology, University of Amsterdam, The Netherlands.
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J Dankert
Department of Medical Microbiology, University of Amsterdam, The Netherlands.
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ABSTRACT

Since immunization of infants with conjugated Haemophilus influenzae type b (Hib) capsular polysaccharide (PS) vaccines results in a reduction of colonization, we determined the inhibitory effect of anti-Hib PS on two steps in the colonization, i.e., adherence of H. influenzae to nasopharyngeal epithelium and bacterial growth. Monoclonal antibody (MAb) E117-5 specific for Hib PS inhibited at a concentration of at least 80 microg/ml in vitro the adherence of Hib strain 770235f+b+ to oropharyngeal epithelial cells by 50% (P <, 0.02), but this MAb and sera from children immunized with Hib PS conjugate vaccine (n = 10) were not inhibitory in final dilutions containing up to 20 microg of anti-Hib PS per ml. The growth of Hib strain 770235f+b+ did completely stop in the presence of 5 microg of anti-Hib PS MAb E117-5 per ml and human sera with an anti-Hib PS concentration of 2 microg/ml or more, in contrast to the growth of the nonencapsular variant strain 770235f+b0.

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Antibodies to Haemophilus influenzae type b polysaccharide affect bacterial adherence and multiplication.
L van Alphen, P Eijk, H Käyhty, J van Marle, J Dankert
Infection and Immunity Mar 1996, 64 (3) 995-1001; DOI:

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Antibodies to Haemophilus influenzae type b polysaccharide affect bacterial adherence and multiplication.
L van Alphen, P Eijk, H Käyhty, J van Marle, J Dankert
Infection and Immunity Mar 1996, 64 (3) 995-1001; DOI:
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