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Comparative Study | Journal Article | Research Support, Non-U.S. Gov't

Arabinose assimilation defines a nonvirulent biotype of Burkholderia pseudomallei.

M D Smith, B J Angus, V Wuthiekanun, N J White
M D Smith
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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B J Angus
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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V Wuthiekanun
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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N J White
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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ABSTRACT

Two distinct types of Burkholderia pseudomallei, differentiated by the ability to assimilate L-arabinose but with similar morphologies and antigenicities, can be isolated from soil in Thailand. Approximately 25% of soil isolates from northeast Thailand were arabinose assimilators (Ara+), but in 1,200 sequentially studied patients, only arabinose "nonassimilators" (Ara-) caused melioidosis (P < 0.0001). In a murine model, there was a striking difference in virulence between Ara- and Ara+ B. pseudomallei. The mean (standard deviation) 50% lethal dose (LD[50]) inoculum for Ara- isolates was 182 (111) CFU/mouse compared with approximately 10(9) CFU/mouse for Ara+ soil isolates. There was no significant difference between the LD(50)s for clinical and soil Ara- isolates. All attempts to convert the biochemical phenotype by selective culture failed, which suggests that the biotype is stable.

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Arabinose assimilation defines a nonvirulent biotype of Burkholderia pseudomallei.
M D Smith, B J Angus, V Wuthiekanun, N J White
Infection and Immunity Oct 1997, 65 (10) 4319-4321; DOI:

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Arabinose assimilation defines a nonvirulent biotype of Burkholderia pseudomallei.
M D Smith, B J Angus, V Wuthiekanun, N J White
Infection and Immunity Oct 1997, 65 (10) 4319-4321; DOI:
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