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Journal Article

Pathogenicity of Escherichia coli O157:H7 in the intestines of neonatal calves.

E A Dean-Nystrom, B T Bosworth, W C Cray Jr, H W Moon
E A Dean-Nystrom
Enteric Diseases and Food Safety Research Unit, National Animal Disease Center, USDA Agricultural Research Service, Ames, Iowa 50010, USA. enystrom@nadc.ars.usda.gov
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B T Bosworth
Enteric Diseases and Food Safety Research Unit, National Animal Disease Center, USDA Agricultural Research Service, Ames, Iowa 50010, USA. enystrom@nadc.ars.usda.gov
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W C Cray Jr
Enteric Diseases and Food Safety Research Unit, National Animal Disease Center, USDA Agricultural Research Service, Ames, Iowa 50010, USA. enystrom@nadc.ars.usda.gov
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H W Moon
Enteric Diseases and Food Safety Research Unit, National Animal Disease Center, USDA Agricultural Research Service, Ames, Iowa 50010, USA. enystrom@nadc.ars.usda.gov
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ABSTRACT

Cattle are an important reservoir of Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) O157:H7 strains, foodborne pathogens that cause hemorrhagic colitis and hemolytic uremic syndrome in humans. EHEC O157:H7 strains are not pathogenic in calves >3 weeks old. Our objective was to determine if EHEC O157:H7 strains are pathogenic in neonatal calves. Calves <36 h old inoculated with EHEC O157:H7 developed diarrhea and enterocolitis with attaching and effacing (A/E) lesions in both the large and small intestines by 18 h postinoculation. The severity of diarrhea and inflammation, and also the frequency and extent of A/E lesions, increased by 3 days postinoculation. We conclude that EHEC O157:H7 strains are pathogenic in neonatal calves. The neonatal calf model is relevant for studying the pathogenesis of EHEC O157:H7 infections in cattle. It should also be useful for identifying ways to reduce EHEC O157:H7 infections in cattle and thus reduce the risk of EHEC O157:H7 disease in humans.

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Pathogenicity of Escherichia coli O157:H7 in the intestines of neonatal calves.
E A Dean-Nystrom, B T Bosworth, W C Cray Jr, H W Moon
Infection and Immunity May 1997, 65 (5) 1842-1848; DOI:

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Pathogenicity of Escherichia coli O157:H7 in the intestines of neonatal calves.
E A Dean-Nystrom, B T Bosworth, W C Cray Jr, H W Moon
Infection and Immunity May 1997, 65 (5) 1842-1848; DOI:
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