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Host Response and Inflammation

Inducible Nitric Oxide Synthase Does Not Affect Resolution of Murine Chlamydial Genital Tract Infections or Eradication of Chlamydiae in Primary Murine Cell Culture

Kyle H. Ramsey, Gurwattan S. Miranpuri, Christoffer E. Poulsen, Nancy B. Marthakis, Laima M. Braune, Gerald I. Byrne
Kyle H. Ramsey
Microbiology Department, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, and
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Gurwattan S. Miranpuri
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706
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Christoffer E. Poulsen
Microbiology Department, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, and
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Nancy B. Marthakis
Microbiology Department, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, and
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Laima M. Braune
Microbiology Department, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, and
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Gerald I. Byrne
Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53706
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DOI: 10.1128/IAI.66.2.835-838.1998
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ABSTRACT

Mice lacking inducible nitric oxide synthase (iNOS) or treated with iNOS inhibitors resolved chlamydial genital tract infections. Additionally, treatment of primary murine cell cultures with gamma interferon restricted chlamydial growth in the absence of nitric oxide. From these results, iNOS activity is unnecessary for the resolution of chlamydial genital tract infections in mice and inhibition of chlamydial growth in culture.

  • Copyright © 1998 American Society for Microbiology
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Inducible Nitric Oxide Synthase Does Not Affect Resolution of Murine Chlamydial Genital Tract Infections or Eradication of Chlamydiae in Primary Murine Cell Culture
Kyle H. Ramsey, Gurwattan S. Miranpuri, Christoffer E. Poulsen, Nancy B. Marthakis, Laima M. Braune, Gerald I. Byrne
Infection and Immunity Feb 1998, 66 (2) 835-838; DOI: 10.1128/IAI.66.2.835-838.1998

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Inducible Nitric Oxide Synthase Does Not Affect Resolution of Murine Chlamydial Genital Tract Infections or Eradication of Chlamydiae in Primary Murine Cell Culture
Kyle H. Ramsey, Gurwattan S. Miranpuri, Christoffer E. Poulsen, Nancy B. Marthakis, Laima M. Braune, Gerald I. Byrne
Infection and Immunity Feb 1998, 66 (2) 835-838; DOI: 10.1128/IAI.66.2.835-838.1998
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KEYWORDS

Chlamydia Infections
Chlamydia trachomatis
Genital Diseases, Female
nitric oxide synthase

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