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Microbial Immunity and Vaccines

Local and Systemic Neutralizing Antibody Responses Induced by Intranasal Immunization with the Nontoxic Binding Domain of Toxin A from Clostridium difficile

Stephen J. Ward, Gill Douce, Gordon Dougan, Brendan W. Wren
Stephen J. Ward
Microbial Pathogenicity Research Group, Department of Microbiology, St. Bartholomew’s and the Royal London School of Medicine and Dentistry, West Smithfield, London ECIA 7BE, and
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Gill Douce
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom
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Gordon Dougan
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom
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Brendan W. Wren
Microbial Pathogenicity Research Group, Department of Microbiology, St. Bartholomew’s and the Royal London School of Medicine and Dentistry, West Smithfield, London ECIA 7BE, and
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DOI: 10.1128/IAI.67.10.5124-5132.1999
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Article Information

DOI 
https://doi.org/10.1128/IAI.67.10.5124-5132.1999
PubMed 
10496886

Published By 
American Society for Microbiology Journals
History 
  • Received April 9, 1999
  • Returned for modification May 26, 1999
  • Accepted July 27, 1999
  • Published online October 1, 1999.

Copyright & Usage 
Copyright © 1999 American Society for Microbiology

Author Information

  1. Stephen J. Ward1†,
  2. Gill Douce2†,
  3. Gordon Dougan2 and
  4. Brendan W. Wren1*
  1. Microbial Pathogenicity Research Group, Department of Microbiology, St. Bartholomew’s and the Royal London School of Medicine and Dentistry, West Smithfield, London ECIA 7BE,1 and
  2. Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ,2 United Kingdom
  • ↵* Corresponding author. Mailing address: Department of Infectious and Tropical Diseases, The London School of Hygiene and Tropical Medicine, Keppel St., London WC1E 7H7, United Kingdom. Phone: 44 (0) 171 927 2288. E-mail: BrendanWren{at}Lshtm.ac.uk.

  • ↵† Present address: Medeva Development, Vaccine Research Unit, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom.

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Local and Systemic Neutralizing Antibody Responses Induced by Intranasal Immunization with the Nontoxic Binding Domain of Toxin A from Clostridium difficile
Stephen J. Ward, Gill Douce, Gordon Dougan, Brendan W. Wren
Infection and Immunity Oct 1999, 67 (10) 5124-5132; DOI: 10.1128/IAI.67.10.5124-5132.1999

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Local and Systemic Neutralizing Antibody Responses Induced by Intranasal Immunization with the Nontoxic Binding Domain of Toxin A from Clostridium difficile
Stephen J. Ward, Gill Douce, Gordon Dougan, Brendan W. Wren
Infection and Immunity Oct 1999, 67 (10) 5124-5132; DOI: 10.1128/IAI.67.10.5124-5132.1999
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KEYWORDS

Antibodies, Bacterial
bacterial toxins
Clostridium difficile
enterotoxins
Peptide Fragments

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