Local and Systemic Neutralizing Antibody Responses Induced by Intranasal Immunization with the Nontoxic Binding Domain of Toxin A from Clostridium difficile

Stephen J. Ward; Gill Douce; Gordon Dougan; Brendan W. Wren

doi:10.1128/IAI.67.10.5124-5132.1999

DOI: 10.1128/IAI.67.10.5124-5132.1999

Article Information

DOI

https://doi.org/10.1128/IAI.67.10.5124-5132.1999

PubMed

10496886

Published By

American Society for Microbiology Journals

History

Received April 9, 1999
Returned for modification May 26, 1999
Accepted July 27, 1999
Published online October 1, 1999.

Author Information

Stephen J. Ward¹ ^†,
Gill Douce² ^†,
Gordon Dougan² and
Brendan W. Wren¹ *

Microbial Pathogenicity Research Group, Department of Microbiology, St. Bartholomew’s and the Royal London School of Medicine and Dentistry, West Smithfield, London ECIA 7BE,¹ and
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ,² United Kingdom

↵* Corresponding author. Mailing address: Department of Infectious and Tropical Diseases, The London School of Hygiene and Tropical Medicine, Keppel St., London WC1E 7H7, United Kingdom. Phone: 44 (0) 171 927 2288. E-mail: BrendanWren{at}Lshtm.ac.uk.
↵† Present address: Medeva Development, Vaccine Research Unit, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom.

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