Article Figures & Data
Figures
- Fig. 1.
Comparative histopathological analysis of brain sections of mice sacrificed 8 days after inoculation with 2 × 105C. neoformans organisms/mouse (panel 1) and of an AIDS patient who died of disseminated cryptococcosis (panel 2). Magnification, ×1,000. The strain inoculated into mice was cultured from the patient. LM, leptomeninges; E, edema; C, cyst.
- Fig. 2.
Distribution of TNF-α, IL-10, and IL-6 baseline levels in plasma of AIDS patients with cryptococcosis according to the presence (□) or absence (▨) of fungemia (A) (n = 27 and 24, respectively), dissemination (B) (n = 36 and 15, respectively), and culture-confirmed meningitis (C) (n = 44 and 7, respectively). Lines through boxes show medians, with other quartiles at either end. Bars show the 10th and 90th centiles. Dots represent individual values above the 90th centile or below the 10th centile. Significant differences between patients with or without fungemia and with or without dissemination were found for TNF-α (P = 0.001 and P = 0.01, respectively) and IL-10 (P = 0.002 and P = 0.04, respectively) in plasma.
- Fig. 3.
Fungal burden and TNF-α, IL-6, and IL-10 levels in plasma and in spleen and brain homogenates in OF1 mice. Mice were sacrificed on days 3 (□), 6 (░), 8 (▧), and 10 (■) after inoculation with 2 × 106C. neoformansorganisms. Results are expressed as means ± standard errors of the means (n = 5 in each group).
- Fig. 4.
TNF-α and IL-6 levels in plasma and in spleen, lung, and brain homogenates 8 days after inoculation of OF1 mice with 2 × 104 (□), 2 × 105 (░), or 2 × 106 (▨) C. neoformans organisms/mouse. Results are expressed as means ± standard errors of the means (n = 5 in each group).
- Fig. 5.
Correlations between TNF-α in plasma plotted versus fungal burden in buffy coat (A) or brain (B) in OF1 mice. Mice were sacrificed between days 6 and 10 after inoculation with 2 × 106C. neoformans organisms. Each dot represents an individual sample (n = 27).
- Fig. 6.
IFN-γ levels in plasma and in spleen and brain homogenates of OF1 mice. Mice were sacrificed on days 3 (□), 6 (░), 8 (▨), and 10 (■) after inoculation with 2 × 106C. neoformans organisms. Results are expressed as means ± standard errors of the means (n = 5 in each group).
