DOI: 10.1128/IAI.67.7.3667-3669.1999
ABSTRACT
The sigB gene of Staphylococcus aureus, coding for the alternate sigma factor B, has been deleted by allelic replacement mutagenesis. The mutant grew as well as the parent in vitro, although it was deficient in clumping factor, coagulase, and pigment. In two murine and one rat infection model the mutant showed no reduction in virulence.
- Copyright © 1999 American Society for Microbiology