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Host Response and Inflammation

Differential Host Inflammatory Responses to Viable Versus Antibiotic-Killed Bacteria in Experimental Microbial Sepsis

Richard Silverstein, John G. Wood, Qiao Xue, Mari Norimatsu, David L. Horn, David C. Morrison
Richard Silverstein
Departments of Biochemistry and Molecular Biology,
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John G. Wood
Molecular and Integrative Physiology, and
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Qiao Xue
Departments of Biochemistry and Molecular Biology,
Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160;
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Mari Norimatsu
Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160;
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David L. Horn
U.S. Human Health Division, Merck & Co., Inc., West Point, Pennsylvania 19486;
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David C. Morrison
Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160;
Departments of Basic Medical Sciences and Anesthesiology, School of Medicine, University of Missouri at Kansas City, Kansas City, Missouri 64108; and
Office of Medical Research Administration, Saint Luke's Hospital, Kansas City, Missouri 64111
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DOI: 10.1128/IAI.68.4.2301-2308.2000
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Article Information

DOI 
https://doi.org/10.1128/IAI.68.4.2301-2308.2000
PubMed 
10722633

Published By 
American Society for Microbiology Journals
History 
  • Received October 11, 1999
  • Returned for modification November 30, 1999
  • Accepted December 28, 1999
  • Published online April 1, 2000.

Copyright & Usage 
Copyright © 2000 American Society for Microbiology

Author Information

  1. Richard Silverstein1*,
  2. John G. Wood2,
  3. Qiao Xue1,3,
  4. Mari Norimatsu3†,
  5. David L. Horn4‡ and
  6. David C. Morrison3,5,6
  1. Departments of Biochemistry and Molecular Biology,1
  2. Molecular and Integrative Physiology,2 and
  3. Microbiology, Molecular Genetics, and Immunology,3 University of Kansas Medical Center, Kansas City, Kansas 66160;
  4. U.S. Human Health Division, Merck & Co., Inc., West Point, Pennsylvania 194864;
  5. Departments of Basic Medical Sciences and Anesthesiology, School of Medicine, University of Missouri at Kansas City, Kansas City, Missouri 641085; and
  6. Office of Medical Research Administration, Saint Luke's Hospital, Kansas City, Missouri 641116
  • ↵* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160. Phone: (913) 588-6954. Fax: (913) 588-7440. E-mail: rsilvers{at}kumc.edu.

  • ↵† Present address: Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN, United Kingdom.; ‡ Present address: Bristol-Myers Squibb, Oncology/Immunology, Princeton, NJ 08543.

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Differential Host Inflammatory Responses to Viable Versus Antibiotic-Killed Bacteria in Experimental Microbial Sepsis
Richard Silverstein, John G. Wood, Qiao Xue, Mari Norimatsu, David L. Horn, David C. Morrison
Infection and Immunity Apr 2000, 68 (4) 2301-2308; DOI: 10.1128/IAI.68.4.2301-2308.2000

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Differential Host Inflammatory Responses to Viable Versus Antibiotic-Killed Bacteria in Experimental Microbial Sepsis
Richard Silverstein, John G. Wood, Qiao Xue, Mari Norimatsu, David L. Horn, David C. Morrison
Infection and Immunity Apr 2000, 68 (4) 2301-2308; DOI: 10.1128/IAI.68.4.2301-2308.2000
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KEYWORDS

Anti-Bacterial Agents
Escherichia coli
sepsis
Staphylococcus aureus
Tumor Necrosis Factor-alpha

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