Article Figures & Data
Figures
- Fig. 1.
Urease-specific serum IgG (A, B, and C) and salivary IgA (D, E, and F) for monkeys which received sham immunization (A and D), oral immunization with urease plus E. coli LT (B and E), or intramuscular urease plus Bay (C and F). Results are shown for samples obtained before immunization (0 week), 2 weeks following immunization (14 weeks), just prior to challenge (arrow), and at 4 and 11 weeks (IgG only) after challenge (18 and 25 weeks, respectively). Serum IgG is expressed as the reciprocal of the lowest titer to exceed a threshold of 0.10 absorbance unit. Salivary IgA is expressed asA550.
- Fig. 2.
Mean log10 CFU/gram of tissue obtained at endoscopy 4 weeks after challenge (A) and at necropsy 11 weeks after challenge (B) with H. pylori. Results for each animal are averaged for six samples at endoscopy and for 11 samples at necropsy. Means for animals that received sham vaccination (control), oral urease (PO), and parenteral urease vaccination (IM) are shown as bars.
- Fig. 3.
RFLP analysis of H. pylori DNA digested withHaeIII. Samples are from strains isolated from naturally infected monkeys at the primate center (lanes 1 to 3), strain N246C3 used as the inoculum in the present experiment (lane 4), and strains isolated from each of the 11 experimental animals (lanes 5 to 15). A size ladder in kilobases is shown at left.
- Fig. 4.
Mean H. pylori log10 CFU/gram of gastric tissue in the cardia (C), body (B), junction (J), antrum (A), and pylorus (P) averaged over all 11 monkeys. The standard deviation is indicated above each bar.
- Fig. 5.
Gastritis score for acute (polymorphonuclear leukocytes) inflammation on a scale of 0 (none), 1 (mild), 2 (moderate), or 3 (severe) as described in the Sydney System (30). Data are shown for each animal in the control, oral vaccine (PO), and parenteral vaccine (IM) groups before immunization (0 week), 4 weeks after challenge (18 weeks), and 11 weeks after challenge (25 weeks).
