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Infection and Immunity
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Molecular Pathogenesis

Mutator Natural Escherichia coliIsolates Have an Unusual Virulence Phenotype

Bertrand Picard, Patrick Duriez, Stéphanie Gouriou, Ivan Matic, Erick Denamur, François Taddei
Bertrand Picard
Laboratoire de Microbiologie, Facultéde Médecine, Brest, and
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Patrick Duriez
INSERM U458, Hôpital Robert Debré and
INSERM E9916, Hôpital Necker-Enfants Malades, Paris, France
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Stéphanie Gouriou
Laboratoire de Microbiologie, Facultéde Médecine, Brest, and
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Ivan Matic
INSERM E9916, Hôpital Necker-Enfants Malades, Paris, France
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Erick Denamur
INSERM U458, Hôpital Robert Debré and
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François Taddei
INSERM E9916, Hôpital Necker-Enfants Malades, Paris, France
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DOI: 10.1128/IAI.69.1.9-14.2001
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ABSTRACT

A small percentage of natural Escherichia coli isolates (both commensal and pathogenic) have a mutator phenotype related to defects in methyl-directed mismatch repair (MR) genes. We investigated whether there was a direct link between the mutator phenotype and virulence by (i) studying the relationships between mutation rate and virulence in a mouse model of extraintestinal virulence for 88 commensal and extraintestinal pathogenic E. coli isolates and (ii) comparing the virulence in mice of MR-deficient and MR-proficient strains that were otherwise isogenic. The results provide no support for the hypothesis that the mutator phenotype has a direct role in virulence or is associated with increased virulence. Most of the natural mutator strains studied displayed an unusual virulence phenotype with (i) a lack of correspondence between the number of virulence determinants and pathogenicity in mice and (ii) an intermediate level of virulence. On a large evolutionary scale, the mutator phenotype may help parasites to achieve an intermediate rate of virulence which mathematical models predict to be selected for during long-term parasite-host interactions.

  • Copyright © 2001 American Society for Microbiology
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Mutator Natural Escherichia coliIsolates Have an Unusual Virulence Phenotype
Bertrand Picard, Patrick Duriez, Stéphanie Gouriou, Ivan Matic, Erick Denamur, François Taddei
Infection and Immunity Jan 2001, 69 (1) 9-14; DOI: 10.1128/IAI.69.1.9-14.2001

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Mutator Natural Escherichia coliIsolates Have an Unusual Virulence Phenotype
Bertrand Picard, Patrick Duriez, Stéphanie Gouriou, Ivan Matic, Erick Denamur, François Taddei
Infection and Immunity Jan 2001, 69 (1) 9-14; DOI: 10.1128/IAI.69.1.9-14.2001
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KEYWORDS

Base Pair Mismatch
DNA Repair
Escherichia coli

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