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Host Response and Inflammation

Micrococci and Peptidoglycan Activate TLR2→MyD88→IRAK→TRAF→NIK→IKK→NF-κB Signal Transduction Pathway That Induces Transcription of Interleukin-8

Qiuling Wang, Roman Dziarski, Carsten J. Kirschning, Marta Muzio, Dipika Gupta
Qiuling Wang
Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408;
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Roman Dziarski
Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408;
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Carsten J. Kirschning
Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany; and
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Marta Muzio
Department of Immunology and Cell Biology, Mario Negri Institute, I-20157 Milan, Italy
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Dipika Gupta
Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408;
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DOI: 10.1128/IAI.69.4.2270-2276.2001
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Article Information

DOI 
https://doi.org/10.1128/IAI.69.4.2270-2276.2001
PubMed 
11254583

Published By 
American Society for Microbiology Journals
History 
  • Received September 11, 2000
  • Returned for modification November 22, 2000
  • Accepted January 25, 2001
  • Published online April 1, 2001.

Copyright & Usage 
Copyright © 2001 American Society for Microbiology

Author Information

  1. Qiuling Wang1†,
  2. Roman Dziarski1,
  3. Carsten J. Kirschning2,
  4. Marta Muzio3 and
  5. Dipika Gupta1*
  1. Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 464081;
  2. Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany2; and
  3. Department of Immunology and Cell Biology, Mario Negri Institute, I-20157 Milan, Italy3
  • ↵* Corresponding author. Mailing address: Northwest Center for Medical Education, Indiana University School of Medicine, 3400 Broadway, Gary, IN 46408. Phone: (219) 980-6557. Fax: (219) 980-6566. E-mail:dgupta{at}meded.iun.indiana.edu.

  • ↵† Present address: Washington University School of Medicine, St. Louis, MO 63110.

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Micrococci and Peptidoglycan Activate TLR2→MyD88→IRAK→TRAF→NIK→IKK→NF-κB Signal Transduction Pathway That Induces Transcription of Interleukin-8
Qiuling Wang, Roman Dziarski, Carsten J. Kirschning, Marta Muzio, Dipika Gupta
Infection and Immunity Apr 2001, 69 (4) 2270-2276; DOI: 10.1128/IAI.69.4.2270-2276.2001

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Micrococci and Peptidoglycan Activate TLR2→MyD88→IRAK→TRAF→NIK→IKK→NF-κB Signal Transduction Pathway That Induces Transcription of Interleukin-8
Qiuling Wang, Roman Dziarski, Carsten J. Kirschning, Marta Muzio, Dipika Gupta
Infection and Immunity Apr 2001, 69 (4) 2270-2276; DOI: 10.1128/IAI.69.4.2270-2276.2001
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KEYWORDS

Antigens, Differentiation
Drosophila Proteins
Interleukin-8
Membrane Glycoproteins
Micrococcus
NF-kappa B
peptidoglycan
Protein Kinases
Protein-Serine-Threonine Kinases
Proteins
Receptors, Cell Surface
Receptors, Immunologic
signal transduction

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