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Host Response and Inflammation

Different Subsets of Enteric Bacteria Induce and Perpetuate Experimental Colitis in Rats and Mice

Heiko C. Rath, Michael Schultz, René Freitag, Levinus A. Dieleman, Fengling Li, Hans-Jörg Linde, Jürgen Schölmerich, R. Balfour Sartor
Heiko C. Rath
Center for GI Biology and Disease, University of North Carolina, Chapel Hill, North Carolina,and
Department of Internal Medicine I and
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Michael Schultz
Center for GI Biology and Disease, University of North Carolina, Chapel Hill, North Carolina,and
Department of Internal Medicine I and
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René Freitag
Department of Internal Medicine I and
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Levinus A. Dieleman
Center for GI Biology and Disease, University of North Carolina, Chapel Hill, North Carolina,and
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Fengling Li
Center for GI Biology and Disease, University of North Carolina, Chapel Hill, North Carolina,and
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Hans-Jörg Linde
Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany
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Jürgen Schölmerich
Department of Internal Medicine I and
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R. Balfour Sartor
Center for GI Biology and Disease, University of North Carolina, Chapel Hill, North Carolina,and
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DOI: 10.1128/IAI.69.4.2277-2285.2001
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ABSTRACT

Resident bacteria are incriminated in the pathogenesis of experimental colitis and inflammatory bowel diseases. We investigated the relative roles of various enteric bacteria populations in the induction and perpetuation of experimental colitis. HLA-B27 transgenic rats received antibiotics (ciprofloxacin, metronidazole, or vancomycin-imipenem) in drinking water or water alone in either prevention or treatment protocols. Mice were treated similarly with metronidazole or vancomycin-imipenem before or after receiving 5% dextran sodium sulfate (DSS). Germfree transgenic rats were colonized with specific-pathogen-free enteric bacteria grown overnight either in anaerobic or aerobic atmospheres. Nontransgenic rats colonized with anaerobic bacteria served as negative controls. Although preventive metronidazole significantly attenuated colitis in transgenic rats and DSS-treated mice, it had no therapeutic benefit once colitis was established. Ciprofloxacin also partially prevented but did not treat colitis in B27 transgenic rats. In both animal models vancomycin-imipenem most effectively prevented and treated colitis. Germfree transgenic rats reconstituted with enteric bacteria grown under anaerobic conditions had more aggressive colitis than those associated with aerobic bacteria. These results suggest that a subset of resident luminal bacteria induces colitis, but that a complex interaction of commensal aerobic and anaerobic bacteria provides the constant antigenic drive for chronic immune-mediated colonic inflammation.

  • Copyright © 2001 American Society for Microbiology
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Different Subsets of Enteric Bacteria Induce and Perpetuate Experimental Colitis in Rats and Mice
Heiko C. Rath, Michael Schultz, René Freitag, Levinus A. Dieleman, Fengling Li, Hans-Jörg Linde, Jürgen Schölmerich, R. Balfour Sartor
Infection and Immunity Apr 2001, 69 (4) 2277-2285; DOI: 10.1128/IAI.69.4.2277-2285.2001

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Different Subsets of Enteric Bacteria Induce and Perpetuate Experimental Colitis in Rats and Mice
Heiko C. Rath, Michael Schultz, René Freitag, Levinus A. Dieleman, Fengling Li, Hans-Jörg Linde, Jürgen Schölmerich, R. Balfour Sartor
Infection and Immunity Apr 2001, 69 (4) 2277-2285; DOI: 10.1128/IAI.69.4.2277-2285.2001
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KEYWORDS

colitis
Enterobacteriaceae

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