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Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Salmonella enterica Serovar Typhimurium Induces Cell Death in Bovine Monocyte-Derived Macrophages by Early sipB-Dependent and DelayedsipB-Independent Mechanisms

Renato L. Santos, Renée M. Tsolis, Andreas J. Bäumler, Roger Smith III, L. Garry Adams
Renato L. Santos
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4467, and
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Renée M. Tsolis
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4467, and
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Andreas J. Bäumler
Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University System Health Science Center, College Station, Texas 77843-1114
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Roger Smith III
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4467, and
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L. Garry Adams
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4467, and
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DOI: 10.1128/IAI.69.4.2293-2301.2001
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ABSTRACT

It was previously demonstrated that Salmonella enterica serovar Typhimurium induces cell death with features of apoptosis in murine macrophages. Mice infected withSalmonella serovar Typhimurium develop systemic disease without diarrhea, whereas the infection in cattle and in humans is localized and characterized by diarrhea. Considering these clinical disease expression differences between mice and cattle, we investigated whether serovar Typhimurium is cytotoxic for bovine macrophages. Macrophages infected with serovar Typhimurium grown in the logarithmic phase quickly underwent cell death. Macrophages infected with stationary-phase cultures or with a mutant lacking sipBunderwent no immediate cell death but did develop delayed cytotoxicity, undergoing cell death between 12 and 18 h postinfection. Both pathways were temporarily blocked by the general caspase inhibitor Z-VAD-Fmk and by the caspase 1 inhibitor Z-YVAD-Fmk. Comparisons of macrophages from cattle naturally resistant or susceptible to intracellular pathogens indicated no differences between these two genetic backgrounds in terms of susceptibility to serovar Typhimurium-induced cell death. We conclude thatSalmonella serovar Typhimurium induces cell death in bovine macrophages by two distinct mechanisms, earlysipB-mediated and delayedsipB-independent mechanisms.

  • Copyright © 2001 American Society for Microbiology
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Salmonella enterica Serovar Typhimurium Induces Cell Death in Bovine Monocyte-Derived Macrophages by Early sipB-Dependent and DelayedsipB-Independent Mechanisms
Renato L. Santos, Renée M. Tsolis, Andreas J. Bäumler, Roger Smith III, L. Garry Adams
Infection and Immunity Apr 2001, 69 (4) 2293-2301; DOI: 10.1128/IAI.69.4.2293-2301.2001

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Salmonella enterica Serovar Typhimurium Induces Cell Death in Bovine Monocyte-Derived Macrophages by Early sipB-Dependent and DelayedsipB-Independent Mechanisms
Renato L. Santos, Renée M. Tsolis, Andreas J. Bäumler, Roger Smith III, L. Garry Adams
Infection and Immunity Apr 2001, 69 (4) 2293-2301; DOI: 10.1128/IAI.69.4.2293-2301.2001
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KEYWORDS

apoptosis
Bacterial Proteins
macrophages
membrane proteins
Salmonella Typhimurium

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