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Molecular Pathogenesis

Disruption of the Genes for ClpXP Protease in Salmonella enterica Serovar Typhimurium Results in Persistent Infection in Mice, and Development of Persistence Requires Endogenous Gamma Interferon and Tumor Necrosis Factor Alpha

Tomoko Yamamoto, Hiroshi Sashinami, Akiko Takaya, Toshifumi Tomoyasu, Hidenori Matsui, Yuji Kikuchi, Tomoko Hanawa, Shigeru Kamiya, Akio Nakane
Tomoko Yamamoto
Division of Microbiology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba 263-8522,
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Hiroshi Sashinami
Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki 036-8562,
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Akiko Takaya
Division of Microbiology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba 263-8522,
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Toshifumi Tomoyasu
Division of Microbiology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba 263-8522,
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Hidenori Matsui
Center for Basic Research, The Kitasato Institute, Tokyo 108-8642, and
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Yuji Kikuchi
Center for Basic Research, The Kitasato Institute, Tokyo 108-8642, and
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Tomoko Hanawa
Department of Infectious Diseases, Kyorin University School of Medicine, Mitaka 181-8611, Japan
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Shigeru Kamiya
Department of Infectious Diseases, Kyorin University School of Medicine, Mitaka 181-8611, Japan
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Akio Nakane
Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki 036-8562,
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DOI: 10.1128/IAI.69.5.3164-3174.2001
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Article Information

DOI 
https://doi.org/10.1128/IAI.69.5.3164-3174.2001
PubMed 
11292737

Published By 
American Society for Microbiology Journals
History 
  • Received December 4, 2000
  • Returned for modification January 8, 2001
  • Accepted February 9, 2001
  • Published online May 1, 2001.

Copyright & Usage 
Copyright © 2001 American Society for Microbiology

Author Information

  1. Tomoko Yamamoto1*,
  2. Hiroshi Sashinami2,
  3. Akiko Takaya1,
  4. Toshifumi Tomoyasu1,
  5. Hidenori Matsui3,
  6. Yuji Kikuchi3,
  7. Tomoko Hanawa4,
  8. Shigeru Kamiya4 and
  9. Akio Nakane2
  1. Division of Microbiology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba 263-8522,1
  2. Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki 036-8562,2
  3. Center for Basic Research, The Kitasato Institute, Tokyo 108-8642,3 and
  4. Department of Infectious Diseases, Kyorin University School of Medicine, Mitaka 181-8611,4 Japan
  • ↵* Corresponding author. Mailing address: Division of Microbiology, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. Phone: 81-43-290-2928. Fax: 81-43-290-2929. E-mail:tomoko-y{at}p.chiba-u.ac.jp.

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Disruption of the Genes for ClpXP Protease in Salmonella enterica Serovar Typhimurium Results in Persistent Infection in Mice, and Development of Persistence Requires Endogenous Gamma Interferon and Tumor Necrosis Factor Alpha
Tomoko Yamamoto, Hiroshi Sashinami, Akiko Takaya, Toshifumi Tomoyasu, Hidenori Matsui, Yuji Kikuchi, Tomoko Hanawa, Shigeru Kamiya, Akio Nakane
Infection and Immunity May 2001, 69 (5) 3164-3174; DOI: 10.1128/IAI.69.5.3164-3174.2001

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Disruption of the Genes for ClpXP Protease in Salmonella enterica Serovar Typhimurium Results in Persistent Infection in Mice, and Development of Persistence Requires Endogenous Gamma Interferon and Tumor Necrosis Factor Alpha
Tomoko Yamamoto, Hiroshi Sashinami, Akiko Takaya, Toshifumi Tomoyasu, Hidenori Matsui, Yuji Kikuchi, Tomoko Hanawa, Shigeru Kamiya, Akio Nakane
Infection and Immunity May 2001, 69 (5) 3164-3174; DOI: 10.1128/IAI.69.5.3164-3174.2001
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KEYWORDS

Adenosine Triphosphatases
Escherichia coli Proteins
Interferon-gamma
Salmonella Infections, Animal
Salmonella Typhimurium
Serine Endopeptidases
Tumor Necrosis Factor-alpha

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