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Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Francisella tularensis Induces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication

Xin-He Lai, Igor Golovliov, Anders Sjöstedt
Xin-He Lai
Department of Clinical Microbiology, Clinical Bacteriology, Umeå University, SE-901 85 Umeå, Sweden
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Igor Golovliov
Department of Clinical Microbiology, Clinical Bacteriology, Umeå University, SE-901 85 Umeå, Sweden
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Anders Sjöstedt
Department of Clinical Microbiology, Clinical Bacteriology, Umeå University, SE-901 85 Umeå, Sweden
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DOI: 10.1128/IAI.69.7.4691-4694.2001
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ABSTRACT

The murine macrophage-like cell line J774.A1 ingests and allows intracellular growth of Francisella tularensis. We demonstrate that, after 24 h of infection, a pronounced cytopathogenicity resulted and the J774 cells were undergoing apoptosis. Despite this host cell apoptosis, no decrease in bacterial numbers was observed. When internalization of bacteria was prevented or intracellularly located F. tularensis bacteria were eradicated within 12 h, the progression of host cell cytopathogenicity and apoptosis was prevented.

  • Copyright © 2001 American Society for Microbiology
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Francisella tularensis Induces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication
Xin-He Lai, Igor Golovliov, Anders Sjöstedt
Infection and Immunity Jul 2001, 69 (7) 4691-4694; DOI: 10.1128/IAI.69.7.4691-4694.2001

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Francisella tularensis Induces Cytopathogenicity and Apoptosis in Murine Macrophages via a Mechanism That Requires Intracellular Bacterial Multiplication
Xin-He Lai, Igor Golovliov, Anders Sjöstedt
Infection and Immunity Jul 2001, 69 (7) 4691-4694; DOI: 10.1128/IAI.69.7.4691-4694.2001
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KEYWORDS

apoptosis
Francisella tularensis

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