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Bacterial Infections

Characterization of Two Novel Pyrogenic Toxin Superantigens Made by an Acute Rheumatic Fever Clone of Streptococcus pyogenes Associated with Multiple Disease Outbreaks

Laura M. Smoot, John K. McCormick, James C. Smoot, Nancy P. Hoe, Ian Strickland, Robert L. Cole, Kent D. Barbian, Cathleen A. Earhart, Douglas H. Ohlendorf, L. George Veasy, Harry R. Hill, Donald Y. M. Leung, Patrick M. Schlievert, James M. Musser
Laura M. Smoot
1Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840
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John K. McCormick
2Department of Microbiology
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James C. Smoot
1Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840
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Nancy P. Hoe
1Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840
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Ian Strickland
3Division of Pediatric Allergy and Immunology, The National Jewish Medical and Research Center, Denver, Colorado 80262
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Robert L. Cole
1Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840
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Kent D. Barbian
1Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840
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Cathleen A. Earhart
4Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, Minnesota 55455
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Douglas H. Ohlendorf
4Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, Minnesota 55455
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L. George Veasy
5Department of Pediatrics, Primary Children's Medical Center
6Division of Cardiology
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Harry R. Hill
5Department of Pediatrics, Primary Children's Medical Center
7Division of Clinical Immunology, Departments of Pathology, Pediatrics, and Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132
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Donald Y. M. Leung
3Division of Pediatric Allergy and Immunology, The National Jewish Medical and Research Center, Denver, Colorado 80262
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Patrick M. Schlievert
2Department of Microbiology
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James M. Musser
1Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840
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  • For correspondence: jmusser@niaid.nih.gov
DOI: 10.1128/IAI.70.12.7095-7104.2002
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Article Information

DOI 
https://doi.org/10.1128/IAI.70.12.7095-7104.2002
PubMed 
12438391

Published By 
American Society for Microbiology Journals
History 
  • Received June 19, 2002
  • Returned for modification August 8, 2002
  • Accepted August 29, 2002
  • Published online December 1, 2002.

Copyright & Usage 
Copyright © 2002 American Society for Microbiology

Author Information

  1. Laura M. Smoot1†,
  2. John K. McCormick2,
  3. James C. Smoot1†,
  4. Nancy P. Hoe1,
  5. Ian Strickland3,
  6. Robert L. Cole1,
  7. Kent D. Barbian1,
  8. Cathleen A. Earhart4,
  9. Douglas H. Ohlendorf4,
  10. L. George Veasy5,6,
  11. Harry R. Hill5,7,
  12. Donald Y. M. Leung3,
  13. Patrick M. Schlievert2 and
  14. James M. Musser1*
  1. 1Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840
  2. 2Department of Microbiology
  3. 4Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Medical School, Minneapolis, Minnesota 55455
  4. 3Division of Pediatric Allergy and Immunology, The National Jewish Medical and Research Center, Denver, Colorado 80262
  5. 5Department of Pediatrics, Primary Children's Medical Center
  6. 6Division of Cardiology
  7. 7Division of Clinical Immunology, Departments of Pathology, Pediatrics, and Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132
  • ↵* Corresponding author. Mailing address: Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th St., Hamilton, MT 59840. Phone: (406) 363-9315. Fax: (406) 363-9427. E-mail: jmusser{at}niaid.nih.gov .
  • ↵† Present address: Civil and Environmental Engineering, University of Washington, Seattle, WA 98195.; ‡ Present address: The Lawson Health Research Institute, The University of Western Ontario, Grosvenor Campus, London, Ontario N6A 4V2, Canada.

  • Editor: D. L. Burns

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Characterization of Two Novel Pyrogenic Toxin Superantigens Made by an Acute Rheumatic Fever Clone of Streptococcus pyogenes Associated with Multiple Disease Outbreaks
Laura M. Smoot, John K. McCormick, James C. Smoot, Nancy P. Hoe, Ian Strickland, Robert L. Cole, Kent D. Barbian, Cathleen A. Earhart, Douglas H. Ohlendorf, L. George Veasy, Harry R. Hill, Donald Y. M. Leung, Patrick M. Schlievert, James M. Musser
Infection and Immunity Dec 2002, 70 (12) 7095-7104; DOI: 10.1128/IAI.70.12.7095-7104.2002

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Characterization of Two Novel Pyrogenic Toxin Superantigens Made by an Acute Rheumatic Fever Clone of Streptococcus pyogenes Associated with Multiple Disease Outbreaks
Laura M. Smoot, John K. McCormick, James C. Smoot, Nancy P. Hoe, Ian Strickland, Robert L. Cole, Kent D. Barbian, Cathleen A. Earhart, Douglas H. Ohlendorf, L. George Veasy, Harry R. Hill, Donald Y. M. Leung, Patrick M. Schlievert, James M. Musser
Infection and Immunity Dec 2002, 70 (12) 7095-7104; DOI: 10.1128/IAI.70.12.7095-7104.2002
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KEYWORDS

Bacterial Proteins
Disease Outbreaks
Rheumatic Fever
Streptococcus pyogenes
superantigens

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