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Infection and Immunity
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Bacterial Infections

Neisseria lactamica Protects against Experimental Meningococcal Infection

Kerry J. Oliver, Karen M. Reddin, Philippa Bracegirdle, Michael J. Hudson, Ray Borrow, Ian M. Feavers, Andrew Robinson, Keith Cartwright, Andrew R. Gorringe
Kerry J. Oliver
1Centre for Applied Microbiology and Research, Salisbury SP4 0JG
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Karen M. Reddin
1Centre for Applied Microbiology and Research, Salisbury SP4 0JG
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Philippa Bracegirdle
1Centre for Applied Microbiology and Research, Salisbury SP4 0JG
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Michael J. Hudson
1Centre for Applied Microbiology and Research, Salisbury SP4 0JG
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Ray Borrow
2Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester M20 2LR
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Ian M. Feavers
3National Institute for Biological Standards and Control, South Mimms, Potters Bar EN6 3QG
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Andrew Robinson
1Centre for Applied Microbiology and Research, Salisbury SP4 0JG
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Keith Cartwright
4Public Health Laboratory, Gloucestershire Royal Hospital, Gloucester GL1 3NN, United Kingdom
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Andrew R. Gorringe
1Centre for Applied Microbiology and Research, Salisbury SP4 0JG
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  • For correspondence: andrew.gorringe@camr.org.uk
DOI: 10.1128/IAI.70.7.3621-3626.2002
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ABSTRACT

Immunological and epidemiological evidence suggests that the development of natural immunity to meningococcal disease results from colonization of the nasopharynx by commensal Neisseria spp., particularly with N. lactamica. We report here that immunization with N. lactamica killed whole cells, outer membrane vesicles, or outer membrane protein (OMP) pools and protected mice against lethal challenge by a number of diverse serogroup B and C meningococcal isolates in a model of bacteremic infection. Sera raised to N. lactamica killed whole cells, OMPs, or protein pools were found to cross-react with meningococcal isolates of a diverse range of genotypes and phenotypes. The results confirm the potential of N. lactamica to form the basis of a vaccine against meningococcal disease.

  • Copyright © 2002 American Society for Microbiology
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Neisseria lactamica Protects against Experimental Meningococcal Infection
Kerry J. Oliver, Karen M. Reddin, Philippa Bracegirdle, Michael J. Hudson, Ray Borrow, Ian M. Feavers, Andrew Robinson, Keith Cartwright, Andrew R. Gorringe
Infection and Immunity Jul 2002, 70 (7) 3621-3626; DOI: 10.1128/IAI.70.7.3621-3626.2002

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Neisseria lactamica Protects against Experimental Meningococcal Infection
Kerry J. Oliver, Karen M. Reddin, Philippa Bracegirdle, Michael J. Hudson, Ray Borrow, Ian M. Feavers, Andrew Robinson, Keith Cartwright, Andrew R. Gorringe
Infection and Immunity Jul 2002, 70 (7) 3621-3626; DOI: 10.1128/IAI.70.7.3621-3626.2002
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KEYWORDS

bacteremia
Meningococcal Infections
Neisseria
Neisseria meningitidis

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