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Fungal and Parasitic Infections

Antibodies That Inhibit Plasmodium falciparum Adhesion to Chondroitin Sulfate A Are Associated with Increased Birth Weight and the Gestational Age of Newborns

Patrick E. Duffy, Michal Fried
Patrick E. Duffy
1Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington 98109
2Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910
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  • For correspondence: patrick.duffy@sbri.org
Michal Fried
1Malaria Antigen Discovery Program, Seattle Biomedical Research Institute, Seattle, Washington 98109
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DOI: 10.1128/IAI.71.11.6620-6623.2003
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ABSTRACT

Antibodies that inhibit Plasmodium falciparum adhesion to the placental receptor chondroitin sulfate A are associated with a reduced risk of placental malaria, but whether these antibodies lead to improved pregnancy outcomes is unknown. We measured antiadhesion antibody levels in parturient women in western Kenya, where malaria transmission is intense. Secundigravid women with antiadhesion activity in their plasma delivered babies that were on average 398 g heavier (P = 0.019) and 2 weeks more mature (P = 0.002) than babies delivered to secundigravidas without antiadhesion activity. Our findings support the development of antiadhesion vaccines to prevent poor fetal outcomes due to pregnancy malaria.

  • Copyright © 2003 American Society for Microbiology
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Antibodies That Inhibit Plasmodium falciparum Adhesion to Chondroitin Sulfate A Are Associated with Increased Birth Weight and the Gestational Age of Newborns
Patrick E. Duffy, Michal Fried
Infection and Immunity Oct 2003, 71 (11) 6620-6623; DOI: 10.1128/IAI.71.11.6620-6623.2003

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Antibodies That Inhibit Plasmodium falciparum Adhesion to Chondroitin Sulfate A Are Associated with Increased Birth Weight and the Gestational Age of Newborns
Patrick E. Duffy, Michal Fried
Infection and Immunity Oct 2003, 71 (11) 6620-6623; DOI: 10.1128/IAI.71.11.6620-6623.2003
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KEYWORDS

Antibodies, Protozoan
Birth Weight
Chondroitin Sulfates
Malaria Vaccines
Malaria, Falciparum
placenta
Plasmodium falciparum
Pregnancy Complications, Parasitic

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