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Fungal and Parasitic Infections

Interleukin-12 Regulates Chemokine Gene Expression during the Early Immune Response to Leishmania major

Colby Zaph, Phillip Scott
Colby Zaph
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
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Phillip Scott
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
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  • For correspondence: pscott@mail.vet.upenn.edu
DOI: 10.1128/IAI.71.3.1587-1589.2003
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ABSTRACT

Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.

  • Copyright © 2003 American Society for Microbiology
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Interleukin-12 Regulates Chemokine Gene Expression during the Early Immune Response to Leishmania major
Colby Zaph, Phillip Scott
Infection and Immunity Mar 2003, 71 (3) 1587-1589; DOI: 10.1128/IAI.71.3.1587-1589.2003

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Interleukin-12 Regulates Chemokine Gene Expression during the Early Immune Response to Leishmania major
Colby Zaph, Phillip Scott
Infection and Immunity Mar 2003, 71 (3) 1587-1589; DOI: 10.1128/IAI.71.3.1587-1589.2003
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KEYWORDS

chemokines
Gene Expression Regulation
Interleukin-12
Leishmania major
Leishmaniasis, Cutaneous

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