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Molecular Pathogenesis

Complete Genome Sequence and Comparative Genomics of Shigella flexneri Serotype 2a Strain 2457T

J. Wei, M. B. Goldberg, V. Burland, M. M. Venkatesan, W. Deng, G. Fournier, G. F. Mayhew, G. Plunkett III, D. J. Rose, A. Darling, B. Mau, N. T. Perna, S. M. Payne, L. J. Runyen-Janecky, S. Zhou, D. C. Schwartz, F. R. Blattner
J. Wei
1Laboratory of Genetics and Genome Center
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M. B. Goldberg
2Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts 02114
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V. Burland
1Laboratory of Genetics and Genome Center
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M. M. Venkatesan
3Department of Enteric Infections, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910
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W. Deng
1Laboratory of Genetics and Genome Center
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G. Fournier
2Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts 02114
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G. F. Mayhew
1Laboratory of Genetics and Genome Center
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G. Plunkett III
1Laboratory of Genetics and Genome Center
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D. J. Rose
1Laboratory of Genetics and Genome Center
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A. Darling
4Animal Health and Biological Sciences and Genome Center
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B. Mau
4Animal Health and Biological Sciences and Genome Center
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N. T. Perna
4Animal Health and Biological Sciences and Genome Center
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S. M. Payne
5Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712-1095
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L. J. Runyen-Janecky
5Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712-1095
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S. Zhou
6Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706
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D. C. Schwartz
1Laboratory of Genetics and Genome Center
6Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706
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F. R. Blattner
1Laboratory of Genetics and Genome Center
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  • For correspondence: fred@genome.wisc.edu
DOI: 10.1128/IAI.71.5.2775-2786.2003
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  • Complete Genome Sequence and Comparative Genomics of Shigella flexneri Serotype 2a Strain 2457T
    - July 01, 2003

ABSTRACT

We determined the complete genome sequence of Shigella flexneri serotype 2a strain 2457T (4,599,354 bp). Shigella species cause >1 million deaths per year from dysentery and diarrhea and have a lifestyle that is markedly different from those of closely related bacteria, including Escherichia coli. The genome exhibits the backbone and island mosaic structure of E. coli pathogens, albeit with much less horizontally transferred DNA and lacking 357 genes present in E. coli. The strain is distinctive in its large complement of insertion sequences, with several genomic rearrangements mediated by insertion sequences, 12 cryptic prophages, 372 pseudogenes, and 195 S. flexneri-specific genes. The 2457T genome was also compared with that of a recently sequenced S. flexneri 2a strain, 301. Our data are consistent with Shigella being phylogenetically indistinguishable from E. coli. The S. flexneri-specific regions contain many genes that could encode proteins with roles in virulence. Analysis of these will reveal the genetic basis for aspects of this pathogenic organism's distinctive lifestyle that have yet to be explained.

  • Copyright © 2003 American Society for Microbiology
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Complete Genome Sequence and Comparative Genomics of Shigella flexneri Serotype 2a Strain 2457T
J. Wei, M. B. Goldberg, V. Burland, M. M. Venkatesan, W. Deng, G. Fournier, G. F. Mayhew, G. Plunkett III, D. J. Rose, A. Darling, B. Mau, N. T. Perna, S. M. Payne, L. J. Runyen-Janecky, S. Zhou, D. C. Schwartz, F. R. Blattner
Infection and Immunity May 2003, 71 (5) 2775-2786; DOI: 10.1128/IAI.71.5.2775-2786.2003

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Complete Genome Sequence and Comparative Genomics of Shigella flexneri Serotype 2a Strain 2457T
J. Wei, M. B. Goldberg, V. Burland, M. M. Venkatesan, W. Deng, G. Fournier, G. F. Mayhew, G. Plunkett III, D. J. Rose, A. Darling, B. Mau, N. T. Perna, S. M. Payne, L. J. Runyen-Janecky, S. Zhou, D. C. Schwartz, F. R. Blattner
Infection and Immunity May 2003, 71 (5) 2775-2786; DOI: 10.1128/IAI.71.5.2775-2786.2003
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KEYWORDS

Genome, Bacterial
genomics
Shigella flexneri

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