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Infection and Immunity
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Host Response and Inflammation

Association of Tuberculin-Boosted Antibody Responses with Pathology and Cell-Mediated Immunity in Cattle Vaccinated with Mycobacterium bovis BCG and Infected with M. bovis

Konstantin Lyashchenko, Adam O. Whelan, Rena Greenwald, John M. Pollock, Peter Andersen, R. Glyn Hewinson, H. Martin Vordermeier
Konstantin Lyashchenko
1Chembio Diagnostic Systems, Inc., Medford, New York
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Adam O. Whelan
2Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey
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Rena Greenwald
1Chembio Diagnostic Systems, Inc., Medford, New York
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John M. Pollock
3Veterinary Science Division, Department of Agriculture and Rural Affairs of Northern Ireland, Stormont, Belfast, United Kingdom
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Peter Andersen
4Statens Serum Institut, Department of TB Immunlogy, Copenhagen, Denmark
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R. Glyn Hewinson
2Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey
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H. Martin Vordermeier
2Veterinary Laboratories Agency Weybridge, TB Research Group, New Haw, Addlestone, Surrey
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  • For correspondence: m.vordermeier@vla.defra.gsi.gov.uk
DOI: 10.1128/IAI.72.5.2462-2467.2004
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ABSTRACT

Vaccine development and our understanding of the pathology of bovine tuberculosis in cattle would be greatly facilitated by definition of the immunological correlates of protection and/or pathology. In this study we analyzed humoral immune responses in Mycobacterium bovis BCG-vaccinated and control cattle (in particular, the relationship between the intradermal comparative tuberculin skin test and serum immunoglobulin G [IgG] responses) against a range of mycobacterial antigens (MPB59, MPB64, MPB70, MPB83, ESAT-6, CFP-10, Acr1, and PstS-1) by multiantigen print immunoassay and conventional enzyme-linked immunosorbent assay. Following M. bovis infection, the comparative tuberculin skin test strongly boosted IgG, IgG1, and IgG2 antibody responses, particularly against MPB83 and MPB70, in unvaccinated cattle but failed to boost these responses, or did so only weakly, in BCG-vaccinated calves. In addition, the skin test-induced increases in MPB83-specific IgG responses correlated positively with bacterial loads and ESAT-6-induced in vitro gamma interferon responses. In conclusion, both the negative correlation of skin test-enhanced MPB83-specific antibody responses with BCG-induced protection and their positive correlation with bacterial loads can serve as useful markers for vaccine efficacy after challenge.

  • Copyright © 2004 American Society for Microbiology
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Association of Tuberculin-Boosted Antibody Responses with Pathology and Cell-Mediated Immunity in Cattle Vaccinated with Mycobacterium bovis BCG and Infected with M. bovis
Konstantin Lyashchenko, Adam O. Whelan, Rena Greenwald, John M. Pollock, Peter Andersen, R. Glyn Hewinson, H. Martin Vordermeier
Infection and Immunity Apr 2004, 72 (5) 2462-2467; DOI: 10.1128/IAI.72.5.2462-2467.2004

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Association of Tuberculin-Boosted Antibody Responses with Pathology and Cell-Mediated Immunity in Cattle Vaccinated with Mycobacterium bovis BCG and Infected with M. bovis
Konstantin Lyashchenko, Adam O. Whelan, Rena Greenwald, John M. Pollock, Peter Andersen, R. Glyn Hewinson, H. Martin Vordermeier
Infection and Immunity Apr 2004, 72 (5) 2462-2467; DOI: 10.1128/IAI.72.5.2462-2467.2004
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KEYWORDS

Antibodies, Bacterial
BCG vaccine
Tuberculin
Tuberculosis, Bovine

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