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Bacterial Infections

Potential Involvement of Gelatinases and Their Inhibitors in Mannheimia haemolytica Pneumonia in Cattle

Amanda E. Starr, Tonima Dan, Kanwal Minhas, Patricia E. Shewen, Brenda L. Coomber
Amanda E. Starr
1Departments of Biomedical Sciences
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Tonima Dan
1Departments of Biomedical Sciences
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Kanwal Minhas
1Departments of Biomedical Sciences
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Patricia E. Shewen
2Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
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Brenda L. Coomber
1Departments of Biomedical Sciences
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  • For correspondence: bcoomber@uoguelph.ca
DOI: 10.1128/IAI.72.8.4393-4400.2004
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ABSTRACT

Mannheimia haemolytica infection of the lower respiratory tract of cattle results in a bronchofibrinous pneumonia characterized by massive cellular influx and lung tissue remodeling and scarring. Since altered levels of gelatinases and their inhibitors have been detected in a variety of inflammatory conditions and are associated with tissue remodeling, we examined the presence of gelatinases in lesional and nonlesional lung tissue obtained from calves experimentally infected with M. haemolytica. Lesional tissue had elevated levels of progelatinase A and B and active gelatinase A and B when compared with nonlesional tissue obtained from the same lung lobe. In vitro, M. haemolytica products stimulated production of gelatinase B, but not its activation, by bovine monocytes. Alveolar macrophages showed constitutive production of gelatinase B but no change in response to M. haemolytica products. Bovine neutrophils exposed to M. haemolytica products also released gelatinase B, and there was a significant increase in the activated form of this enzyme. These effects were virtually identical when recombinant O-sialoglycoprotease was used to stimulate these cells. M. haemolytica products also enhanced the expression by bovine monocytes and alveolar macrophages of the tissue inhibitor of metalloproteinase 1. Our results provide evidence that matrix metalloproteinases are activated in lung lesions from cattle with shipping fever and that M. haemolytica virulence products induce production, release, and especially activation of gelatinase B by bovine inflammatory cells in vitro.

  • Copyright © 2004 American Society for Microbiology
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Potential Involvement of Gelatinases and Their Inhibitors in Mannheimia haemolytica Pneumonia in Cattle
Amanda E. Starr, Tonima Dan, Kanwal Minhas, Patricia E. Shewen, Brenda L. Coomber
Infection and Immunity Jul 2004, 72 (8) 4393-4400; DOI: 10.1128/IAI.72.8.4393-4400.2004

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Potential Involvement of Gelatinases and Their Inhibitors in Mannheimia haemolytica Pneumonia in Cattle
Amanda E. Starr, Tonima Dan, Kanwal Minhas, Patricia E. Shewen, Brenda L. Coomber
Infection and Immunity Jul 2004, 72 (8) 4393-4400; DOI: 10.1128/IAI.72.8.4393-4400.2004
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KEYWORDS

Enzyme Precursors
Mannheimia haemolytica
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Pasteurellosis, Pneumonic
Tissue Inhibitor of Metalloproteinases

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