Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Infection and Immunity
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Host Response and Inflammation

Analysis of Serum Cytokines in Patients with Severe Acute Respiratory Syndrome

Yuanchun Zhang, Jing Li, Yuliang Zhan, Lianqiu Wu, Xueying Yu, Wenjian Zhang, Liya Ye, Shiqing Xu, Ruihua Sun, Yunting Wang, Jinning Lou
Yuanchun Zhang
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jing Li
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuliang Zhan
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lianqiu Wu
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xueying Yu
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wenjian Zhang
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Liya Ye
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shiqing Xu
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ruihua Sun
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yunting Wang
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jinning Lou
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People's Republic of China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: Lou.j@mail.com
DOI: 10.1128/IAI.72.8.4410-4415.2004
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIG. 1.
    • Open in new tab
    • Download powerpoint
    FIG. 1.

    Analysis of TNF-α and IL-1 levels in sera of SARS patients. C, control group; S, SARS group; SS, severe SARS group; CS, convalescent SARS group.

  • FIG. 2.
    • Open in new tab
    • Download powerpoint
    FIG. 2.

    Analysis of IL-6 and IFN-γ levels in sera of SARS patients. C, control group; S, SARS group; SS, severe SARS group; CS, convalescent SARS group. Two asterisks indicate that the P value is <0.01.

  • FIG. 3.
    • Open in new tab
    • Download powerpoint
    FIG. 3.

    Analysis of IL-8 and TGF-β levels in sera of SARS patients. C, control group; S, SARS group; SS, severe SARS group; CS, convalescent SARS group. Two asterisks indicate that the P value is <0.01.

  • FIG. 4.
    • Open in new tab
    • Download powerpoint
    FIG. 4.

    Analysis of IL-4 and IL-10 levels in sera of SARS patients. C, control group; S, SARS group; SS, severe SARS group; CS, convalescent SARS group. Two asterisks indicate that the P value is <0.01.

  • FIG. 5.
    • Open in new tab
    • Download powerpoint
    FIG. 5.

    Effect of steroid treatment on serum cytokines. (A) Control group (n = 20), SARS group (S Group) without methylprednisolone treatment (n = 23), and SARS group with methylprednisolone treatment (n = 7). (B) Control group (n = 20), severe SARS group (SS Group) without methylprednisolone treatment (n = 12), and severe SARS group with methylprednisolone treatment (n = 18). The results are expressed as means and standard errors.

Tables

  • Figures
  • TABLE 1.

    Basic information for serum donors

    GroupnNo. of malesNo. of femalesAges (yr)Intensive care unitTime (days)ComplicationsNo. of deaths
    RangeMean
    Control2081221-4934.8
    SARS30191117-8044.1No3-6No0
    Severve SARS3021919-8645.4Yes3-7No4
    Convalescent SARS30151514-6835.3No35-42No0
  • TABLE 2.

    Serum cytokine analysis

    GroupnConcn of cytokinesa
    TNF-α (pg/ml)IL-1α (pg/ml)IL-6 (pg/ml)INF-γ (pg/ml)IL-8 (pg/ml)TGF-β (ng/ml)IL-4 (pg/ml)IL-10 (pg/ml)
    Control2059.6 ± 5.23.72 ± 0.5661 ± 10.170 ± 20.4245 ± 7248.7 ± 12.3101 ± 2248.8 ± 5.8
    SARS3060.1 ± 4.43.80 ± 0.59163 ± 153b63.0 ± 20.4165 ± 51b38.2 ± 15.2c109 ± 1347.0 ± 5.3
    Severe SARS3057.8 ± 5.73.62 ± 0.39517 ± 796b86.5 ± 41.1143 ± 41b37.3 ± 19.1c110 ± 1249.7 ± 12.3
    Convalescent SARS3061.9 ± 7.43.81 ± 0.3368.8 ± 25.939.7 ± 4.9b269 ± 18055.5 ± 13.388 ± 8b169 ± 104b
    • ↵ a The data are means ± standard deviations.

    • ↵ b P < 0.01 for a comparison with the control group.

    • ↵ c P < 0.05 for a comparison with the control group.

PreviousNext
Back to top
Download PDF
Citation Tools
Analysis of Serum Cytokines in Patients with Severe Acute Respiratory Syndrome
Yuanchun Zhang, Jing Li, Yuliang Zhan, Lianqiu Wu, Xueying Yu, Wenjian Zhang, Liya Ye, Shiqing Xu, Ruihua Sun, Yunting Wang, Jinning Lou
Infection and Immunity Jul 2004, 72 (8) 4410-4415; DOI: 10.1128/IAI.72.8.4410-4415.2004

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Infection and Immunity article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Analysis of Serum Cytokines in Patients with Severe Acute Respiratory Syndrome
(Your Name) has forwarded a page to you from Infection and Immunity
(Your Name) thought you would be interested in this article in Infection and Immunity.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Analysis of Serum Cytokines in Patients with Severe Acute Respiratory Syndrome
Yuanchun Zhang, Jing Li, Yuliang Zhan, Lianqiu Wu, Xueying Yu, Wenjian Zhang, Liya Ye, Shiqing Xu, Ruihua Sun, Yunting Wang, Jinning Lou
Infection and Immunity Jul 2004, 72 (8) 4410-4415; DOI: 10.1128/IAI.72.8.4410-4415.2004
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

cytokines
SARS Virus
Severe Acute Respiratory Syndrome

Related Articles

Cited By...

About

  • About IAI
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #IAIjournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0019-9567; Online ISSN: 1098-5522