Analysis of Serum Cytokines in Patients with Severe Acute Respiratory Syndrome

DOI: 10.1128/IAI.72.8.4410-4415.2004

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FIG. 1.
Analysis of TNF-α and IL-1 levels in sera of SARS patients. C, control group; S, SARS group; SS, severe SARS group; CS, convalescent SARS group.
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FIG. 2.
Analysis of IL-6 and IFN-γ levels in sera of SARS patients. C, control group; S, SARS group; SS, severe SARS group; CS, convalescent SARS group. Two asterisks indicate that the P value is <0.01.
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FIG. 3.
Analysis of IL-8 and TGF-β levels in sera of SARS patients. C, control group; S, SARS group; SS, severe SARS group; CS, convalescent SARS group. Two asterisks indicate that the P value is <0.01.
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FIG. 4.
Analysis of IL-4 and IL-10 levels in sera of SARS patients. C, control group; S, SARS group; SS, severe SARS group; CS, convalescent SARS group. Two asterisks indicate that the P value is <0.01.
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FIG. 5.
Effect of steroid treatment on serum cytokines. (A) Control group (n = 20), SARS group (S Group) without methylprednisolone treatment (n = 23), and SARS group with methylprednisolone treatment (n = 7). (B) Control group (n = 20), severe SARS group (SS Group) without methylprednisolone treatment (n = 12), and severe SARS group with methylprednisolone treatment (n = 18). The results are expressed as means and standard errors.

TABLE 1.

Basic information for serum donors

Group	n	No. of males	No. of females	Ages (yr)		Intensive care unit	Time (days)	Complications	No. of deaths
Group	n	No. of males	No. of females	Range	Mean	Intensive care unit	Time (days)	Complications	No. of deaths
Control	20	8	12	21-49	34.8
SARS	30	19	11	17-80	44.1	No	3-6	No	0
Severve SARS	30	21	9	19-86	45.4	Yes	3-7	No	4
Convalescent SARS	30	15	15	14-68	35.3	No	35-42	No	0

TABLE 2.

Serum cytokine analysis