Article Figures & Data
Figures
- FIG. 1.
GMC against each of the serotypes of a 7-valent pneumococcal conjugate vaccine at different time points in infants immunized at 2, 4, 6, and 12 months of age with PncCRM (n = 54 to 56), PncOMPC (n = 44 to 55), or a control vaccine (n = 53 or 54).
- FIG. 2.
Reverse cumulative distribution curves demonstrating the percentages of children achieving various serum IgG antibody concentrations against each of the vaccine serotypes at various ages. The children were immunized at 2, 4, 6, and 12 months of age with a pneumococcal conjugate vaccine, PncCRM (n = 54 to 56) or PncOMPC (n = 44 to 55).
- FIG. 3.
Percentages and 95% confidence intervals of infants with an antibody concentrations of ≥0.35 μg/ml at 7, 12, 13, and 24 months of age. The infants were immunized at 2, 4, 6, and 12 months of age with a 7-valent pneumococcal conjugate vaccine, PncCRM (n = 54 to 56) or PncOMPC (n = 44 to 55), or a control vaccine (n = 53 or 54).
- FIG. 4.
MAIs and 95% confidence intervals of anti-pneumococcal type 6B, 19F, and 23F capsular polysaccharide IgG antibodies in infants immunized at 2, 4, 6, and 12 months of age with 7-valent pneumococcal conjugate vaccine, PncCRM (n = 53 to 56) or PncOMPC (n = 44 to 53), or a control vaccine (n = 40 to 47).
Tables
- TABLE 1.
GMCs of serum IgG antibodies to pneumococcal capsular PSs in infants immunized with a 7-valent pneumococcal conjugate vaccine or control vaccine at 2, 4, and 6 months of age and boosted with a homologous vaccine at 12 months of age
Serotype Vaccine GMC [μg/ml (95% CI)] in infants at age (mo): 2 (n = 52-58) 7 (n = 53-55) 12 (n = 52-56) 13 (n = 46-55) 24 (n = 44-54) 4 PncCRM 0.12 (0.09-0.17) 1.71 (1.32-2.20) 0.42 (0.34-0.53) 2.55 (1.99-3.27) 0.50 (0.40-0.62) PncOMPC 0.17 (0.13-0.24) 2.74 (1.92-3.91) 1.12 (0.85-1.48) 4.63 (3.09-6.95) 1.11 (0.85-1.45) Control 0.10 (0.08-0.14) 0.05 (0.04-0.07) 0.09 (0.07-0.12) 0.11 (0.08-0.14) 0.19 (0.15-0.25) 6B PncCRM 0.21 (0.15-0.30) 1.99 (1.35-2.95) 0.92 (0.64-1.32) 9.02 (6.48-12.54) 1.48 (1.11-1.99) PncOMPC 0.26 (0.18-0.36) 0.40 (0.29-0.54) 0.50 (0.37-0.67) 1.76 (1.15-2.67) 0.95 (0.65-1.39) Control 0.16 (0.11-0.22) 0.09 (0.07-0.12) 0.13 (0.10-0.18) 0.15 (0.12-0.20) 0.25 (0.19-0.32) 9V PncCRM 0.26 (0.19-0.35) 2.47 (1.97-3.11) 0.81 (0.66-1.00) 3.97 (3.20-4.91) 0.87 (0.67-1.12) PncOMPC 0.24 (0.18-0.33) 1.98 (1.55-2.54) 1.03 (0.8-1.33) 4.05 (3.14-5.22) 1.21 (0.87-1.69) Control 0.20 (0.15-0.27) 0.10 (0.07-0.13) 0.17 (0.13-0.23) 0.21 (0.16-0.27) 0.33 (0.25-0.45) 14 PncCRM 0.28 (0.19-0.41) 6.26 (4.77-8.20) 2.63 (2.12-3.26) 10.80 (8.29-14.06) 1.86 (1.47-2.36) PncOMPC 0.38 (0.26-0.56) 2.96 (2.05-4.25) 1.25 (0.93-1.68) 5.31 (3.68-7.66) 1.50 (1.06-2.13) Control 0.46 (0.31-0.68) 0.21 (0.16-0.27) 0.19 (0.15-0.24) 0.21 (0.17-0.27) 0.28 (0.21-0.37) 18C PncCRM 0.16 (0.11-0.23) 3.55 (2.80-4.49) 0.88 (0.73-1.07) 6.51 (5.04-8.42) 0.99 (0.77-1.28) PncOMPC 0.21 (0.15-0.30) 1.03 (0.76-1.40) 0.56 (0.44-0.72) 3.06 (2.27-4.12) 0.70 (0.51-0.97) Control 0.24 (0.16-0.34) 0.08 (0.06-0.11) 0.09 (0.07-0.11) 0.10 (0.08-0.13) 0.20 (0.13-0.29) 19F PncCRM 0.42 (0.30-0.60) 3.28 (2.56-4.20) 0.86 (0.65-1.13) 4.96 (3.86-6.36) 2.14 (1.47-3.12) PncOMPC 0.54 (0.39-0.75) 3.54 (2.74-4.57) 2.37 (1.65-3.40) 8.58 (6.10-12.08) 4.80 (2.95-7.82) Control 0.37 (0.26-0.52) 0.22 (0.17-0.29) 0.34 (0.24-0.46) 0.40 (0.31-0.53) 0.62 (0.47-0.82) 23F PncCRM 0.19 (0.13-0.28) 2.51 (1.84-3.43) 0.79 (0.59-1.05) 6.20 (4.51-8.52) 1.28 (0.98-1.68) PncOMPC 0.32 (0.23-0.45) 0.62 (0.46-0.82) 0.64 (0.47-0.86) 2.14 (1.54-2.99) 1.05 (0.76-1.44) Control 0.18 (0.13-0.25) 0.10 (0.07-0.12) 0.13 (0.10-0.18) 0.15 (0.12-0.20) 0.23 (0.17-0.31)
