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Molecular Pathogenesis

The TibA Adhesin/Invasin from Enterotoxigenic Escherichia coli Is Self Recognizing and Induces Bacterial Aggregation and Biofilm Formation

Orla Sherlock, Rebecca Munk Vejborg, Per Klemm
Orla Sherlock
Microbial Adhesion Group, Centre for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark
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Rebecca Munk Vejborg
Microbial Adhesion Group, Centre for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark
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Per Klemm
Microbial Adhesion Group, Centre for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark
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  • For correspondence: pkl@biocentrum.dtu.dk
DOI: 10.1128/IAI.73.4.1954-1963.2005
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ABSTRACT

Escherichia coli strains are responsible for many cases of gastrointestinal disease and represent a serious health problem worldwide. An essential step in the pathogenesis of such strains involves recognition and attachment to host intestinal surfaces. TibA is a potent bacterial adhesin associated with a number of enterotoxigenic E. coli strains and mediates bacterial attachment to a variety of human cells; additionally, it promotes invasion of such cells. This adhesin is a surface-displayed autotransporter protein and belongs to the exclusive group of bacterial glycoproteins; only the glycosylated form confers binding to and invasion of mammalian cells. Here we characterized TibA and showed that it possesses self-association characteristics and can mediate autoaggregation of E. coli cells. We demonstrated that intercellular TibA-TibA interaction is responsible for bacterial autoaggregation. Also, TibA expression significantly enhances biofilm formation by E. coli on abiotic surfaces.

  • Copyright © 2005 American Society for Microbiology
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The TibA Adhesin/Invasin from Enterotoxigenic Escherichia coli Is Self Recognizing and Induces Bacterial Aggregation and Biofilm Formation
Orla Sherlock, Rebecca Munk Vejborg, Per Klemm
Infection and Immunity Mar 2005, 73 (4) 1954-1963; DOI: 10.1128/IAI.73.4.1954-1963.2005

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The TibA Adhesin/Invasin from Enterotoxigenic Escherichia coli Is Self Recognizing and Induces Bacterial Aggregation and Biofilm Formation
Orla Sherlock, Rebecca Munk Vejborg, Per Klemm
Infection and Immunity Mar 2005, 73 (4) 1954-1963; DOI: 10.1128/IAI.73.4.1954-1963.2005
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KEYWORDS

Adhesins, Escherichia coli
biofilms
Escherichia coli

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