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Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

The Translocated Salmonella Effector Proteins SseF and SseG Interact and Are Required To Establish an Intracellular Replication Niche

Jörg Deiwick, Suzana P. Salcedo, Emmanuel Boucrot, Sarah M. Gilliland, Thomas Henry, Nele Petermann, Scott R. Waterman, Jean-Pierre Gorvel, David W. Holden, Stéphane Méresse
Jörg Deiwick
1Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Parc Scientifique de Luminy, Case 906-13288, Marseille Cedex 9, France
3Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
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  • For correspondence: deiwick@biochem.uni-luebeck.de
Suzana P. Salcedo
2Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, United Kingdom
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Emmanuel Boucrot
1Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Parc Scientifique de Luminy, Case 906-13288, Marseille Cedex 9, France
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Sarah M. Gilliland
2Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, United Kingdom
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Thomas Henry
1Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Parc Scientifique de Luminy, Case 906-13288, Marseille Cedex 9, France
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Nele Petermann
3Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
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Scott R. Waterman
2Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, United Kingdom
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Jean-Pierre Gorvel
1Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Parc Scientifique de Luminy, Case 906-13288, Marseille Cedex 9, France
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David W. Holden
2Department of Infectious Diseases, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, United Kingdom
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Stéphane Méresse
1Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Parc Scientifique de Luminy, Case 906-13288, Marseille Cedex 9, France
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DOI: 10.1128/IAI.00648-06
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ABSTRACT

The facultative intracellular pathogen Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. Inside epithelial cells, Salmonella replicates in vacuoles, which localize in the perinuclear area in close proximity to the Golgi apparatus. Among the effector proteins translocated by the Salmonella pathogenicity island 2-encoded type III secretion system, SifA and SseG have been shown necessary but not sufficient to ensure the intracellular positioning of Salmonella vacuoles. Hence, we have investigated the involvement of other secreted effector proteins in this process. Here we show that SseF interacts functionally and physically with SseG but not SifA and is also required for the perinuclear localization of Salmonella vacuoles. The observations show that the intracellular positioning of Salmonella vacuoles is a complex phenomenon resulting from the combined action of several effector proteins.

  • Copyright © 2006 American Society for Microbiology
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The Translocated Salmonella Effector Proteins SseF and SseG Interact and Are Required To Establish an Intracellular Replication Niche
Jörg Deiwick, Suzana P. Salcedo, Emmanuel Boucrot, Sarah M. Gilliland, Thomas Henry, Nele Petermann, Scott R. Waterman, Jean-Pierre Gorvel, David W. Holden, Stéphane Méresse
Infection and Immunity Nov 2006, 74 (12) 6965-6972; DOI: 10.1128/IAI.00648-06

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The Translocated Salmonella Effector Proteins SseF and SseG Interact and Are Required To Establish an Intracellular Replication Niche
Jörg Deiwick, Suzana P. Salcedo, Emmanuel Boucrot, Sarah M. Gilliland, Thomas Henry, Nele Petermann, Scott R. Waterman, Jean-Pierre Gorvel, David W. Holden, Stéphane Méresse
Infection and Immunity Nov 2006, 74 (12) 6965-6972; DOI: 10.1128/IAI.00648-06
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KEYWORDS

Bacterial Proteins
Salmonella enterica
Vacuoles

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