Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): Localization of complement component 3 in the capsule of Cryptococcus neoformans following incubation in human serum (top panels) or mouse serum (bottom panels). The capsule edge (red) is identified by use of a monoclonal antibody specific for the capsule; the binding site of C3 is identified by use of a polyclonal antibody specific for human or mouse C3 (green). Also shown are differential interference contrast images of the same cells. (See related article on page 3096.)