Infection and Immunity: 75 (12)

December 2007; Volume 75,Issue 12

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Articles of Significant Interest Selected from This Issue by the Editors

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Regulatory Networks Controlling Vibrio cholerae Virulence Gene Expression
Jyl S. Matson, Jeffrey H. Withey, Victor J. DiRita

Molecular Pathogenesis

Molecular Pathogenesis
Identification of a Wzy Polymerase Required for Group IV Capsular Polysaccharide and Lipopolysaccharide Biosynthesis in Vibrio vulnificus
Alina Nakhamchik, Caroline Wilde, Dean A. Rowe-Magnus
Molecular Pathogenesis
Contribution of Moraxella catarrhalis Type IV Pili to Nasopharyngeal Colonization and Biofilm Formation
Nicole R. Luke, Joseph A. Jurcisek, Lauren O. Bakaletz, Anthony A. Campagnari
Molecular Pathogenesis
The Streptococcus pyogenes Serotype M49 Nra-Ralp3 Transcriptional Regulatory Network and Its Control of Virulence Factor Expression from the Novel eno ralp3 epf sagA Pathogenicity Region
Bernd Kreikemeyer, Masanobu Nakata, Thomas Köller, Hendrikje Hildisch, Vassilios Kourakos, Kerstin Standar, Shigetada Kawabata, Michael O. Glocker, Andreas Podbielski
Molecular Pathogenesis
Use of Peptide-Major Histocompatibility Complex Tetramer Technology To Study Interactions between Staphylococcus aureus Proteins and Human Cells
Ruth C. Massey, Thomas J. Scriba, Eric L. Brown, Rodney E. Phillips, Andrew K. Sewell
Molecular Pathogenesis
α-Enolase Resides on the Cell Surface of Mycoplasma fermentans and Binds Plasminogen
Amichai Yavlovich, Hagai Rechnitzer, Shlomo Rottem
Molecular Pathogenesis
High-Affinity Zn²⁺ Uptake System ZnuABC Is Required for Bacterial Zinc Homeostasis in Intracellular Environments and Contributes to the Virulence of Salmonella enterica
Serena Ammendola, Paolo Pasquali, Claudia Pistoia, Paola Petrucci, Patrizia Petrarca, Giuseppe Rotilio, Andrea Battistoni
Molecular Pathogenesis
PspA and PspC Minimize Immune Adherence and Transfer of Pneumococci from Erythrocytes to Macrophages through Their Effects on Complement Activation
Jie Li, David T. Glover, Alexander J. Szalai, Susan K. Hollingshead, David E. Briles
Molecular Pathogenesis
Identification of Novel Listeria monocytogenes Secreted Virulence Factors following Mutational Activation of the Central Virulence Regulator, PrfA
Gary C. Port, Nancy E. Freitag
Molecular Pathogenesis
The TolC-Like Protein of Neisseria meningitidis Is Required for Extracellular Production of the Repeats-in-Toxin Toxin FrpC but Not for Resistance to Antimicrobials Recognized by the Mtr Efflux Pump System
Nazia Kamal, Corinne Rouquette-Loughlin, William M. Shafer

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Evidence for a Common Role for the Serine-Type Plasmodium falciparum Serine Repeat Antigen Proteases: Implications for Vaccine and Drug Design
Joanne E. McCoubrie, Susanne K. Miller, Tobias Sargeant, Robert T. Good, Anthony N. Hodder, Terence P. Speed, Tania F. de Koning-Ward, Brendan S. Crabb
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Sel1 Repeat Protein LpnE Is a Legionella pneumophila Virulence Determinant That Influences Vacuolar Trafficking
Hayley J. Newton, Fiona M. Sansom, Jenny Dao, Adrian D. McAlister, Joan Sloan, Nicholas P. Cianciotto, Elizabeth L. Hartland
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Chlamydia pneumoniae Inclusion Membrane Protein Cpn0585 Interacts with Multiple Rab GTPases
Claudio Cortes, Kimberly A. Rzomp, Amy Tvinnereim, Marci A. Scidmore, Benjamin Wizel
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Chlamydia trachomatis Species-Specific Induction of Ezrin Tyrosine Phosphorylation Functions in Pathogen Entry
Kena A. Swanson, Deborah D. Crane, Harlan D. Caldwell
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Haemophilus ducreyi Partially Activates Human Myeloid Dendritic Cells
Keith E. Banks, Tricia L. Humphreys, Wei Li, Barry P. Katz, David S. Wilkes, Stanley M. Spinola
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Sialyl-Lewis x-Independent Infection of Human Myeloid Cells by Anaplasma phagocytophilum Strains HZ and HGE1
Madhubanti Sarkar, Dexter V. Reneer, Jason A. Carlyon

Bacterial Infections

Bacterial Infections
Neutrophils Play an Important Role in Host Resistance to Respiratory Infection with Acinetobacter baumannii in Mice
Henk van Faassen, Rhonda KuoLee, Greg Harris, Xigeng Zhao, J. Wayne Conlan, Wangxue Chen
Bacterial Infections
Transgenic Mice Expressing Human Transferrin as a Model for Meningococcal Infection
Maria-Leticia Zarantonelli, Marek Szatanik, Dario Giorgini, Eva Hong, Michel Huerre, Florian Guillou, Jean-Michel Alonso, Muhamed-Kheir Taha
Bacterial Infections
Effects of Endogenous d-Alanine Synthesis and Autoinhibition of Bacillus anthracis Germination on In Vitro and In Vivo Infections
Matthew T. McKevitt, Katie M. Bryant, Salika M. Shakir, Jason L. Larabee, Steven R. Blanke, Julie Lovchik, C. Rick Lyons, Jimmy D. Ballard
Bacterial Infections
Novel Model To Study Virulence Determinants of Escherichia coli K1
Naveed Ahmed Khan, Graham John Goldsworthy
Bacterial Infections
Role of Streptococcus gordonii Surface Proteins SspA/SspB and Hsa in Platelet Function
Steven W. Kerrigan, Nicholas S. Jakubovics, Ciara Keane, Patricia Maguire, Kieran Wynne, Howard F. Jenkinson, Dermot Cox
Bacterial Infections
Effect of Zinc in Enteropathogenic Escherichia coli Infection
John K. Crane, Tonniele M. Naeher, Irina Shulgina, Chengru Zhu, Edgar C. Boedeker

Host Response and Inflammation

Host Response and Inflammation
Gamma Interferon Confers Resistance to Infection with Staphylococcus aureus in Human Vascular Endothelial Cells by Cooperative Proinflammatory and Enhanced Intrinsic Antibacterial Activities
Henry Beekhuizen, Joke S. van de Gevel
Host Response and Inflammation
Comparison of Tissue-Selective Proinflammatory Gene Induction in Mice Infected with Wild-Type, DNA Adenine Methylase-Deficient, and Flagellin-Deficient Salmonella enterica
Raphael Simon, Douglas M. Heithoff, Michael J. Mahan, Charles E. Samuel
Host Response and Inflammation
Individual Matrix Metalloproteinases Control Distinct Transcriptional Responses in Airway Epithelial Cells Infected with Pseudomonas aeruginosa
Sean Y. Kassim, Sina A. Gharib, Brigham H. Mecham, Timothy P. Birkland, William C. Parks, John K. McGuire
Host Response and Inflammation
Dysregulated Immune Profiles for Skin and Dendritic Cells Are Associated with Increased Host Susceptibility to Haemophilus ducreyi Infection in Human Volunteers
Tricia L. Humphreys, Lang Li, Xiaoman Li, Diane M. Janowicz, Kate R. Fortney, Qianqian Zhao, Wei Li, Jeanette McClintick, Barry P. Katz, David S. Wilkes, Howard J. Edenberg, Stanley M. Spinola
Host Response and Inflammation
Specific Intracellular Adhesion Molecule-Grabbing Nonintegrin R1 Is Not Involved in the Murine Antibody Response to Pneumococcal Polysaccharides
Leen Moens, Axel Jeurissen, Greet Wuyts, Padraic G. Fallon, Boon Louis, Jan L. Ceuppens, Xavier Bossuyt
Host Response and Inflammation
Gamma Interferon-Independent Effects of Interleukin-12 on Immunity to Salmonella enterica Serovar Typhimurium
Jason D. Price, Kim R. Simpfendorfer, Radhakrishnam R. Mantena, James Holden, William R. Heath, Nico van Rooijen, Richard A. Strugnell, Odilia L. C. Wijburg
Host Response and Inflammation
Treponema denticola Activates Mitogen-Activated Protein Kinase Signal Pathways through Toll-Like Receptor 2
John Ruby, Kunal Rehani, Michael Martin
Host Response and Inflammation
Importance of T Cells, Gamma Interferon, and Tumor Necrosis Factor in Immune Control of the Rapid Grower Mycobacterium abscessus in C57BL/6 Mice
Martin Rottman, Emilie Catherinot, Patrick Hochedez, Jean-François Emile, Jean-Laurent Casanova, Jean-Louis Gaillard, Claire Soudais
Host Response and Inflammation
Interaction of Brucella suis and Brucella abortus Rough Strains with Human Dendritic Cells
Elisabeth Billard, Jacques Dornand, Antoine Gross
Host Response and Inflammation
The Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Induces the Inflammatory Factor Interleukin-8 following Chlamydia trachomatis Infection
Kerry R. Buchholz, Richard S. Stephens
Host Response and Inflammation
The p38 Mitogen-Activated Protein Kinase Signaling Pathway Is Coupled to Toll-Like Receptor 5 To Mediate Gene Regulation in Response to Pseudomonas aeruginosa Infection in Human Airway Epithelial Cells
Zhe Zhang, William Reenstra, Daniel J. Weiner, Jean-Pierre Louboutin, James M. Wilson
Host Response and Inflammation
Chicken Cecum Immune Response to Salmonella enterica Serovars of Different Levels of Invasiveness
Angela Berndt, Anne Wilhelm, Christiane Jugert, Jana Pieper, Konrad Sachse, Ulrich Methner

Fungal and Parasitic Infections

Fungal and Parasitic Infections
Immunoepidemiology of Wuchereria bancrofti Infection: Parasite Transmission Intensity, Filaria-Specific Antibodies, and Host Immunity in Two East African Communities
Walter G. Jaoko, Edwin Michael, Dan W. Meyrowitsch, Benson B. A. Estambale, Mwele N. Malecela, Paul E. Simonsen
Fungal and Parasitic Infections
Role of Neutrophils in Preventing and Resolving Acute Fungal Sinusitis
Tobias E. Rodriguez, Nicole R. Falkowski, Jack R. Harkema, Gary B. Huffnagle
Fungal and Parasitic Infections
Coinfection with Antigenically and Genetically Distinct Virulent Strains of Babesia bovis Is Maintained through All Phases of the Parasite Life Cycle
Shawn J. Berens, Kelly A. Brayton, Terry F. McElwain
Fungal and Parasitic Infections
Evaluation of Two Homologous Proline-Rich Proteins of Coccidioides posadasii as Candidate Vaccines against Coccidioidomycosis
Roger A. Herr, Chiung-Yu Hung, Garry T. Cole
Fungal and Parasitic Infections
Phosphoinositide-3-Kinase-Dependent, MyD88-Independent Induction of CC-Type Chemokines Characterizes the Macrophage Response to Toxoplasma gondii Strains with High Virulence
Chiang W. Lee, Woraporn Sukhumavasi, Eric Y. Denkers
Fungal and Parasitic Infections
Macrophage-Mediated but Gamma Interferon-Independent Innate Immune Responses Control the Primary Wave of Plasmodium yoelii Parasitemia
Kevin N. Couper, Daniel G. Blount, Julius C. R. Hafalla, Nico van Rooijen, J. Brian de Souza, Eleanor M. Riley
Fungal and Parasitic Infections
Combination of Protein and Viral Vaccines Induces Potent Cellular and Humoral Immune Responses and Enhanced Protection from Murine Malaria Challenge
Claire L. Hutchings, Ashley J. Birkett, Anne C. Moore, Adrian V. S. Hill
Fungal and Parasitic Infections
Toll-Like Receptor 2 Regulates CXC Chemokine Production and Neutrophil Recruitment to the Cornea in Onchocerca volvulus/ Wolbachia-Induced Keratitis
Illona Gillette-Ferguson, Katrin Daehnel, Amy G. Hise, Yan Sun, Eric Carlson, Eugenia Diaconu, Helen F. McGarry, Mark J. Taylor, Eric Pearlman
Fungal and Parasitic Infections
Hybrid Cell Vaccination Resolves Leishmania donovani Infection by Eliciting a Strong CD8⁺ Cytotoxic T-Lymphocyte Response with Concomitant Suppression of Interleukin-10 (IL-10) but Not IL-4 or IL-13
Rajatava Basu, Suniti Bhaumik, Arun Kumar Haldar, Kshudiram Naskar, Tripti De, Syamal Kumar Dana, Peter Walden, Syamal Roy

Microbial Immunity and Vaccines

Microbial Immunity and Vaccines
DNA Polymorphisms in the pepA and PPE18 Genes among Clinical Strains of Mycobacterium tuberculosis: Implications for Vaccine Efficacy
Andrea M. Hebert, Sarah Talarico, Dong Yang, Riza Durmaz, Carl F. Marrs, Lixin Zhang, Betsy Foxman, Zhenhua Yang
Microbial Immunity and Vaccines
In Immunization with Plasmodium falciparum Apical Membrane Antigen 1, the Specificity of Antibodies Depends on the Species Immunized
Kazutoyo Miura, Hong Zhou, Olga V. Muratova, Andrew C. Orcutt, Birgitte Giersing, Louis H. Miller, Carole A. Long
Microbial Immunity and Vaccines
Safety and Protective Efficacy of Intramuscular Vaccination with a Live aroA Derivative of Pasteurella multocida B:2 against Experimental Hemorrhagic Septicemia in Calves
Mark P. Dagleish, J. Christopher Hodgson, Saeed Ataei, Anna Finucane, Jeanie Finlayson, Jill Sales, Roger Parton, John G. Coote
Microbial Immunity and Vaccines
Attenuated Coxiella burnetii Phase II Causes a Febrile Response in Gamma Interferon Knockout and Toll-Like Receptor 2 Knockout Mice and Protects against Reinfection
Javier Ochoa-Repáraz, Jami Sentissi, Theresa Trunkle, Carol Riccardi, David W. Pascual
Microbial Immunity and Vaccines
Fusion Proteins Containing Family 1 and Family 2 PspA Fragments Elicit Protection against Streptococcus pneumoniae That Correlates with Antibody-Mediated Enhancement of Complement Deposition
M. Darrieux, E. N. Miyaji, D. M. Ferreira, L. M. Lopes, A. P. Y. Lopes, B. Ren, D. E. Briles, S. K. Hollingshead, L. C. C. Leite
Microbial Immunity and Vaccines
Agonists of Toll-Like Receptors 3, 4, 7, and 9 Are Candidates for Use as Adjuvants in an Outer Membrane Vaccine against Neisseria meningitidis Serogroup B
Floris Fransen, Claire J. Boog, Jos P. van Putten, Peter van der Ley
Microbial Immunity and Vaccines
Malaria Vaccine-Related Benefits of a Single Protein Comprising Plasmodium falciparum Apical Membrane Antigen 1 Domains I and II Fused to a Modified Form of the 19-Kilodalton C-Terminal Fragment of Merozoite Surface Protein 1
Bart W. Faber, Edmond J. Remarque, William D. Morgan, Clemens H. M. Kocken, Anthony A. Holder, Alan W. Thomas
Microbial Immunity and Vaccines
Characterization of the Antibody Response against Plasmodium falciparum Erythrocyte Membrane Protein 1 in Human Volunteers
Darren R. Krause, Michelle L. Gatton, Sarah Frankland, Damon P. Eisen, Michael F. Good, Leann Tilley, Qin Cheng

Molecular Genomics

Molecular Genomics
Genome Differences between Treponema pallidum subsp. pallidum Strain Nichols and T. paraluiscuniculi Strain Cuniculi A
Michal Strouhal, David Šmajs, Petra Matějková, Erica Sodergren, Anita G. Amin, Jerrilyn K. Howell, Steven J. Norris, George M. Weinstock

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Table of Contents

Spotlight

Minireviews

Molecular Pathogenesis

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Bacterial Infections

Host Response and Inflammation

Fungal and Parasitic Infections

Microbial Immunity and Vaccines

Molecular Genomics

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