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Infection and Immunity
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Table of Contents

May 2007; Volume 75,Issue 5

Spotlight

  • Free
    Spotlight
    Articles of Significant Interest Selected from This Issue by the Editors

Molecular Pathogenesis

  • Molecular Pathogenesis
    Role for Gingipains in Porphyromonas gingivalis Traffic to Phagolysosomes and Survival in Human Aortic Endothelial Cells
    Kumiko Yamatake, Maki Maeda, Tomoko Kadowaki, Ryosuke Takii, Takayuki Tsukuba, Takashi Ueno, Eiki Kominami, Sadaki Yokota, Kenji Yamamoto
  • Molecular Pathogenesis
    The Glycan Moieties and the N-Terminal Polypeptide Backbone of a Fimbria-Associated Adhesin, Fap1, Play Distinct Roles in the Biofilm Development of Streptococcus parasanguinis
    Hui Wu, Meiqin Zeng, Paula Fives-Taylor
  • Molecular Pathogenesis
    The Serine 31 Residue of the B Subunit of Shiga Toxin 2 Is Essential for Secretion in Enterohemorrhagic Escherichia coli
    Takeshi Shimizu, Satomi Kawakami, Toshio Sato, Terumi Sasaki, Masato Higashide, Takashi Hamabata, Toshiko Ohta, Masatoshi Noda
  • Molecular Pathogenesis
    Requirements for Assembly of PtlH with the Pertussis Toxin Transporter Apparatus of Bordetella pertussis
    Anita Verma, Drusilla L. Burns
  • Molecular Pathogenesis
    Mechanisms of Decreased Susceptibility to β-Defensins by Treponema denticola
    Catherine A. Brissette, Sheila A. Lukehart
  • Molecular Pathogenesis
    Chlamydial Hsp60-2 Is Iron Responsive in Chlamydia trachomatis Serovar E-Infected Human Endometrial Epithelial Cells In Vitro
    Richard W. LaRue, Brian D. Dill, David K. Giles, Judy D. Whittimore, Jane E. Raulston
  • Molecular Pathogenesis
    Identification of a Prepore Large-Complex Stage in the Mechanism of Action of Clostridium perfringens Enterotoxin
    James G. Smedley, Francisco A. Uzal, Bruce A. McClane
  • Molecular Pathogenesis
    Virulence Plasmid Diversity in Clostridium perfringens Type D Isolates
    Sameera Sayeed, Jihong Li, Bruce A. McClane
  • Molecular Pathogenesis
    The ChrA-ChrS and HrrA-HrrS Signal Transduction Systems Are Required for Activation of the hmuO Promoter and Repression of the hemA Promoter in Corynebacterium diphtheriae
    Lori A. Bibb, Carey A. Kunkle, Michael P. Schmitt
  • Molecular Pathogenesis
    QseA Directly Activates Transcription of LEE1 in Enterohemorrhagic Escherichia coli
    Faith C. Sharp, Vanessa Sperandio
  • Molecular Pathogenesis
    Physiological Osmotic Induction of Leptospira interrogans Adhesion: LigA and LigB Bind Extracellular Matrix Proteins and Fibrinogen
    Henry A. Choy, Melissa M. Kelley, Tammy L. Chen, Annette K. Møller, James Matsunaga, David A. Haake
  • Molecular Pathogenesis
    Characterization of SodC, a Periplasmic Superoxide Dismutase from Burkholderia cenocepacia
    Karen E. Keith, Miguel A. Valvano
  • Molecular Pathogenesis
    Flow Cytometric Analysis of Adherence of Porphyromonas gingivalis to Oral Epithelial Cells
    Rishi D. Pathirana, Neil M. O'Brien-Simpson, Kumar Visvanathan, John A. Hamilton, Eric C. Reynolds
  • Molecular Pathogenesis
    Bile Salts Stimulate Recruitment of IpaB to the Shigella flexneri Surface, Where It Colocalizes with IpaD at the Tip of the Type III Secretion Needle
    Andrew J. Olive, Roma Kenjale, Marianela Espina, David S. Moore, Wendy L. Picking, William D. Picking
  • Molecular Pathogenesis
    Gamma Interferon Suppresses Erythropoiesis via Interleukin-15
    Isis K. Mullarky, Frank M. Szaba, Lawrence W. Kummer, Lindsey B. Wilhelm, Michelle A. Parent, Lawrence L. Johnson, Stephen T. Smiley

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Pet, a Non-AB Toxin, Is Transported and Translocated into Epithelial Cells by a Retrograde Trafficking Pathway
    Fernando Navarro-García, Adrián Canizalez-Roman, Kaitlin E. Burlingame, Ken Teter, Jorge E. Vidal
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Molecular Damage and Induction of Proinflammatory Cytokines in Human Endothelial Cells Exposed to Shiga Toxin 1, Shiga Toxin 2, and α-Sarcin
    Maurizio Brigotti, Domenica Carnicelli, Elisa Ravanelli, Antonio González Vara, Chiara Martinelli, Roberta R. Alfieri, Pier Giorgio Petronini, Piero Sestili
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    The Escherichia coli Enterotoxin STb Permeabilizes Piglet Jejunal Brush Border Membrane Vesicles
    Carina Gonçalves, Vincent Vachon, Jean-Louis Schwartz, J. Daniel Dubreuil
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Enteropathogenic Escherichia coli-Induced Epidermal Growth Factor Receptor Activation Contributes to Physiological Alterations in Intestinal Epithelial Cells
    Jennifer L. Roxas, Athanasia Koutsouris, V. K. Viswanathan
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Shigella flexneri Inhibits Staurosporine-Induced Apoptosis in Epithelial Cells
    Christina S. Clark, Anthony T. Maurelli
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Gingival Epithelial Cell Transcriptional Responses to Commensal and Opportunistic Oral Microbial Species
    Yoshiaki Hasegawa, Jeffrey J. Mans, Song Mao, M. Cecilia Lopez, Henry V. Baker, Martin Handfield, Richard J. Lamont

Bacterial Infections

  • Bacterial Infections
    Invasion and Persistence of Mycobacterium avium subsp. paratuberculosis during Early Stages of Johne's Disease in Calves
    Chia-wei Wu, Michael Livesey, Shelly K. Schmoller, Elizabeth J. B. Manning, Howard Steinberg, William C. Davis, Mary Jo Hamilton, Adel M. Talaat
  • Bacterial Infections
    Molecular Epidemiology and Dynamics of Pseudomonas aeruginosa Populations in Lungs of Cystic Fibrosis Patients
    Lars Jelsbak, Helle Krogh Johansen, Anne-Louise Frost, Regitze Thøgersen, Line E. Thomsen, Oana Ciofu, Lei Yang, Janus A. J. Haagensen, Niels Høiby, Søren Molin
  • Bacterial Infections
    Neisseria gonorrhoeae Catalase Is Not Required for Experimental Genital Tract Infection despite the Induction of a Localized Neutrophil Response
    Ángel A. Soler-García, Ann E. Jerse
  • Bacterial Infections
    Murine Neonates Are Highly Resistant to Yersinia enterocolitica following Orogastric Exposure
    Andrea Echeverry, Kurt Schesser, Becky Adkins
  • Bacterial Infections
    Human Tear Fluid Protects against Pseudomonas aeruginosa Keratitis in a Murine Experimental Model
    Mary S. F. Kwong, David J. Evans, Minjian Ni, Brigitte A. Cowell, Suzanne M. J. Fleiszig
  • Bacterial Infections
    NRAMP1 3′ Untranslated Region Polymorphisms Are Not Associated with Natural Resistance to Brucella abortus in Cattle
    Tatiane A. Paixão, Fernando P. Poester, Alcina V. Carvalho Neta, Álan M. Borges, Andrey P. Lage, Renato L. Santos
  • Bacterial Infections
    Proteomic and Immunoblot Analyses of Bartonella quintana Total Membrane Proteins Identify Antigens Recognized by Sera from Infected Patients
    Jenni K. Boonjakuakul, Helen L. Gerns, Yu-Ting Chen, Linda D. Hicks, Michael F. Minnick, Scott E. Dixon, Steven C. Hall, Jane E. Koehler
  • Bacterial Infections
    In Vivo Adaptation of the Wayne Model of Latent Tuberculosis
    Lisa Woolhiser, Marcela Henao Tamayo, Baolin Wang, Veronica Gruppo, John T. Belisle, Anne J. Lenaerts, Randall J. Basaraba, Ian M. Orme
  • Bacterial Infections
    Enterococcus faecalis Mutations Affecting Virulence in the Caenorhabditis elegans Model Host
    Arash Maadani, Kristina A. Fox, Elftherios Mylonakis, Danielle A. Garsin

Host Response and Inflammation

  • Host Response and Inflammation | Spotlight
    Anthrax Edema Toxin Sensitizes DBA/2J Mice to Lethal Toxin
    Aaron M. Firoved, Mahtab Moayeri, Jason F. Wiggins, Yuequan Shen, Wei-Jen Tang, Stephen H. Leppla
  • Host Response and Inflammation | Spotlight
    Invariant and Noninvariant Natural Killer T Cells Exert Opposite Regulatory Functions on the Immune Response during Murine Schistosomiasis
    Thierry Mallevaey, Josette Fontaine, Laetitia Breuilh, Christophe Paget, Alexandre Castro-Keller, Catherine Vendeville, Monique Capron, Maria Leite-de-Moraes, François Trottein, Christelle Faveeuw
  • Host Response and Inflammation
    Gamma Interferon Responses of CD4 and CD8 T-Cell Subsets Are Quantitatively Different and Independent of Each Other during Pulmonary Mycobacterium bovis BCG Infection
    Patricia Ngai, Sarah McCormick, Cherrie Small, Xizhong Zhang, Anna Zganiacz, Naoko Aoki, Zhou Xing
  • Host Response and Inflammation
    Synthesis and Characterization of a Dipalmitoylated Lipopeptide Derived from Paralogous Lipoproteins of Mycoplasma pneumoniae
    Takeshi Into, Jun-ichi Dohkan, Megumi Inomata, Misako Nakashima, Ken-ichiro Shibata, Kenji Matsushita
  • Host Response and Inflammation
    Modulation of Naive CD4+ T-Cell Responses to an Airway Antigen during Pulmonary Mycobacterial Infection
    Mursalin M. Anis, Scott A. Fulton, Scott M. Reba, Clifford V. Harding, W. Henry Boom
  • Host Response and Inflammation
    Mucosal and Systemic Immune Responses in Patients with Diarrhea Due to CS6-Expressing Enterotoxigenic Escherichia coli
    Firdausi Qadri, Tanvir Ahmed, Firoz Ahmed, M. Saruar Bhuiyan, Mohammad Golam Mostofa, Frederick J. Cassels, Anna Helander, Ann-Mari Svennerholm
  • Host Response and Inflammation
    Immunogenicity of Anaplasma marginale Type IV Secretion System Proteins in a Protective Outer Membrane Vaccine
    Job E. Lopez, Guy H. Palmer, Kelly A. Brayton, Michael J. Dark, Stephanie E. Leach, Wendy C. Brown
  • Host Response and Inflammation
    Broad Up-Regulation of Innate Defense Factors during Acute Cholera
    Carl-Fredrik Flach, Firdausi Qadri, Taufiqur R. Bhuiyan, Nur H. Alam, Eva Jennische, Ivar Lönnroth, Jan Holmgren
  • Host Response and Inflammation
    Role of Bacillus anthracis Spore Structures in Macrophage Cytokine Responses
    Subhendu Basu, Tae Jin Kang, Wilbur H. Chen, Matthew J. Fenton, Les Baillie, Steve Hibbs, Alan S. Cross
  • Host Response and Inflammation
    Induction of Human β-Defensin 2 by the Probiotic Escherichia coli Nissle 1917 Is Mediated through Flagellin
    Miriam Schlee, Jan Wehkamp, Artur Altenhoefer, Tobias A. Oelschlaeger, Eduard F. Stange, Klaus Fellermann
  • Host Response and Inflammation
    Deficiencies of Myeloid Differentiation Factor 88, Toll-Like Receptor 2 (TLR2), or TLR4 Produce Specific Defects in Macrophage Cytokine Secretion Induced by Helicobacter pylori
    Marygorret Obonyo, Mojgan Sabet, Sheri P. Cole, Joerg Ebmeyer, Satoshi Uematsu, Shizuo Akira, Donald G. Guiney
  • Host Response and Inflammation
    Modulation of Gamma Interferon Receptor 1 by Mycobacterium tuberculosis: a Potential Immune Response Evasive Mechanism
    Amit Singhal, Anand Jaiswal, Virendra K. Arora, Hanumanthappa K. Prasad
  • Host Response and Inflammation
    Jun N-Terminal Protein Kinase Enhances Middle Ear Mucosal Proliferation during Bacterial Otitis Media
    Masayuki Furukawa, Jörg Ebmeyer, Kwang Pak, Darrell A. Austin, Åsa Melhus, Nicholas J. G. Webster, Allen F. Ryan
  • Host Response and Inflammation | Spotlight
    Surface Expression of Toll-Like Receptor 9 Is Upregulated on Intestinal Epithelial Cells in Response to Pathogenic Bacterial DNA
    Julia B. Ewaschuk, Jody L. Backer, Thomas A. Churchill, Florian Obermeier, Denis O. Krause, Karen L. Madsen
  • Host Response and Inflammation
    Enhancement of Macrophage Stimulation by Lipoteichoic Acid and the Costimulant Hemoglobin Is Dependent on Toll-Like Receptors 2 and 4
    Kathleen H. Cox, Itzhak Ofek, David L. Hasty

Fungal and Parasitic Infections

  • Fungal and Parasitic Infections
    Mucosal Tissue Invasion by Candida albicans Is Associated with E-Cadherin Degradation, Mediated by Transcription Factor Rim101p and Protease Sap5p
    C. C. Villar, H. Kashleva, C. J. Nobile, A. P. Mitchell, A. Dongari-Bagtzoglou
  • Fungal and Parasitic Infections
    Leishmania donovani-Induced Ceramide as the Key Mediator of Akt Dephosphorylation in Murine Macrophages: Role of Protein Kinase Cζ and Phosphatase
    Ranadhir Dey, Nivedita Majumder, Surajit Bhattacharjee, Suchandra Bhattacharyya Majumdar, Rajdeep Banerjee, Sandipan Ganguly, Pradeep Das, Subrata Majumdar
  • Fungal and Parasitic Infections
    Niche-Specific Activation of the Oxidative Stress Response by the Pathogenic Fungus Candida albicans
    Brice Enjalbert, Donna M. MacCallum, Frank C. Odds, Alistair J. P. Brown
  • Fungal and Parasitic Infections
    CD4+ CD25+ Regulatory T Cells Suppress CD4+ T-Cell Function and Inhibit the Development of Plasmodium berghei-Specific TH1 Responses Involved in Cerebral Malaria Pathogenesis
    Catherine Q. Nie, Nicholas J. Bernard, Louis Schofield, Diana S. Hansen
  • Fungal and Parasitic Infections
    Priming with an Adenovirus 35-Circumsporozoite Protein (CS) Vaccine followed by RTS,S/AS01B Boosting Significantly Improves Immunogenicity to Plasmodium falciparum CS Compared to That with Either Malaria Vaccine Alone
    V. Ann Stewart, Shannon M. McGrath, Patrice M. Dubois, Maria G. Pau, Pascal Mettens, Joseph Shott, Michelle Cobb, J. Robert Burge, David Larson, Lisa A. Ware, Marie-Ange Demoitie, Gerrit Jan Weverling, Babak Bayat, Jerome H. H. V. Custers, Marie-Claude Dubois, Joe Cohen, Jaap Goudsmit, D. Gray Heppner
  • Fungal and Parasitic Infections
    Immunomodulatory Effects of the Lutzomyia longipalpis Salivary Gland Protein Maxadilan on Mouse Macrophages
    Tess M. Brodie, Matthew C. Smith, Robin V. Morris, Richard G. Titus
  • Fungal and Parasitic Infections
    Primary Infection of C57BL/6 Mice with Plasmodium yoelii Induces a Heterogeneous Response of NKT Cells
    Valérie Soulard, Jacques Roland, Christèle Sellier, Anne Charlotte Gruner, Maria Leite-de-Moraes, Jean-François Franetich, Laurent Rénia, Pierre-André Cazenave, Sylviane Pied
  • Fungal and Parasitic Infections
    Uninfected Mosquito Bites Confer Protection against Infection with Malaria Parasites
    Michael J. Donovan, Andrew S. Messmore, Deborah A. Scrafford, David L. Sacks, Shaden Kamhawi, Mary Ann McDowell
  • Fungal and Parasitic Infections | Spotlight
    Toxoplasma gondii Strains Defective in Oral Transmission Are Also Defective in Developmental Stage Differentiation
    Blima Fux, Julie Nawas, Asis Khan, Darcy B. Gill, Chunlei Su, L. David Sibley
  • Fungal and Parasitic Infections
    Interaction of Candida albicans with Adherent Human Peripheral Blood Mononuclear Cells Increases C. albicans Biofilm Formation and Results in Differential Expression of Pro- and Anti-Inflammatory Cytokines
    Jyotsna Chandra, Thomas S. McCormick, Yoshifumi Imamura, Pranab K. Mukherjee, Mahmoud A. Ghannoum

Microbial Immunity and Vaccines

  • Microbial Immunity and Vaccines
    Inactivated Francisella tularensis Live Vaccine Strain Protects against Respiratory Tularemia by Intranasal Vaccination in an Immunoglobulin A-Dependent Fashion
    Shawn D. Baron, Rajendra Singh, Dennis W. Metzger
  • Microbial Immunity and Vaccines | Spotlight
    Safety and Immunogenicity of an Enterotoxigenic Escherichia coli Vaccine Patch Containing Heat-Labile Toxin: Use of Skin Pretreatment To Disrupt the Stratum Corneum
    Gregory M. Glenn, Christina P. Villar, David C. Flyer, A. Louis Bourgeois, Robin McKenzie, Robert M. Lavker, Sarah A. Frech
  • Microbial Immunity and Vaccines
    Th1 and Th2 Cells Help CD8 T-Cell Responses
    Melinda J. Ekkens, Devon J. Shedlock, EuiHye Jung, Amy Troy, Erika L. Pearce, Hao Shen, Edward J. Pearce
  • Microbial Immunity and Vaccines
    CpG Oligodeoxynucleotide Treatment Enhances Innate Resistance and Acquired Immunity to African Trypanosomes
    Tajie H. Harris, John M. Mansfield, Donna M. Paulnock
  • Microbial Immunity and Vaccines
    Immunoglobulin G Antibody Reactivity to a Group A Plasmodium falciparum Erythrocyte Membrane Protein 1 and Protection from P. falciparum Malaria
    Pamela A. Magistrado, John Lusingu, Lasse S. Vestergaard, Martha Lemnge, Thomas Lavstsen, Louise Turner, Lars Hviid, Anja T. R. Jensen, Thor G. Theander
  • Microbial Immunity and Vaccines
    A Live Salmonella enterica Serovar Enteritidis Vaccine Allows Serological Differentiation between Vaccinated and Infected Animals
    Connie Adriaensen, Henri De Greve, Jean Q. Tian, Stéphane De Craeye, Eline Gubbels, Venessa Eeckhaut, Filip Van Immerseel, Richard Ducatelle, Mahesh Kumar, Jean-Pierre Hernalsteens
  • Microbial Immunity and Vaccines
    Live Attenuated Streptococcus pneumoniae Strains Induce Serotype-Independent Mucosal and Systemic Protection in Mice
    Aoife M. Roche, Samantha J. King, Jeffrey N. Weiser
  • Microbial Immunity and Vaccines
    Immunization of Pigs To Prevent Disease in Humans: Construction and Protective Efficacy of a Salmonella enterica Serovar Typhimurium Live Negative-Marker Vaccine
    Martin Selke, Jochen Meens, Sven Springer, Ronald Frank, Gerald-F. Gerlach
  • Microbial Immunity and Vaccines
    A Defined O-Antigen Polysaccharide Mutant of Francisella tularensis Live Vaccine Strain Has Attenuated Virulence while Retaining Its Protective Capacity
    Shite Sebastian, Simon T. Dillon, Jillian G. Lynch, LeeAnn T. Blalock, Emmy Balon, Kristin T. Lee, Laurie E. Comstock, J. Wayne Conlan, Eric J. Rubin, Arthur O. Tzianabos, Dennis L. Kasper
  • Microbial Immunity and Vaccines
    A Booster Vaccination with Mycobacterium bovis BCG Does Not Increase the Protective Effect of the Vaccine against Experimental Mycobacterium ulcerans Infection in Mice
    Audrey Tanghe, Pierre-Yves Adnet, Tatiana Gartner, Kris Huygen

Molecular Genomics

  • Molecular Genomics
    Determination of the Relationship between Group A Streptococcal Genome Content, M Type, and Toxic Shock Syndrome by a Mixed Genome Microarray
    Bart J. M. Vlaminckx, Frank H. J. Schuren, Roy C. Montijn, Martien P. M. Caspers, Ad C. Fluit, Wim J. B. Wannet, Leo M. Schouls, Jan Verhoef, Wouter T. M. Jansen
  • Molecular Genomics
    The Genome of Non-O1 Vibrio cholerae NRT36S Demonstrates the Presence of Pathogenic Mechanisms That Are Distinct from Those of O1 Vibrio cholerae
    Yuansha Chen, Judith A. Johnson, Gordon D. Pusch, J. Glenn Morris, O. Colin Stine
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Infection and Immunity: 75 (5)

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volume 75, issue 5
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  • Pathogenic Mannheimia haemolytica Invades Differentiated Bovine Airway Epithelial Cells
  • Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies
  • An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector
  • Success of Escherichia coli O25b:H4 Sequence Type 131 Clade C Associated with a Decrease in Virulence
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