Infection and Immunity: 76 (8)

August 2008; Volume 76,Issue 8

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Articles of Significant Interest Selected from This Issue by the Editors

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Bacteria in the Intestine, Helpful Residents or Enemies from Within?
Geraldine O. Canny, Beth A. McCormick

Molecular Pathogenesis

Molecular Pathogenesis
A Genome-Wide Proteome Array Reveals a Limited Set of Immunogens in Natural Infections of Humans and White-Footed Mice with Borrelia burgdorferi
Alan G. Barbour, Algimantas Jasinskas, Matthew A. Kayala, D. Huw Davies, Allen C. Steere, Pierre Baldi, Philip L. Felgner
Molecular Pathogenesis
CcpA-Mediated Repression of Streptolysin S Expression and Virulence in the Group A Streptococcus
Traci L. Kinkel, Kevin S. McIver
Molecular Pathogenesis
Specific Roles of the iroBCDEN Genes in Virulence of an Avian Pathogenic Escherichia coli O78 Strain and in Production of Salmochelins
Mélissa Caza, François Lépine, Sylvain Milot, Charles M. Dozois
Molecular Pathogenesis
Sortase A Utilizes an Ancillary Protein Anchor for Efficient Cell Wall Anchoring of Pili in Streptococcus agalactiae
Angela H. Nobbs, Roberto Rosini, C. Daniela Rinaudo, Domenico Maione, Guido Grandi, John L. Telford
Molecular Pathogenesis
Screen for Leukotoxin Mutants in Aggregatibacter actinomycetemcomitans: Genes of the Phosphotransferase System Are Required for Leukotoxin Biosynthesis
Maria P. Isaza, Matthew S. Duncan, Jeffrey B. Kaplan, Scott C. Kachlany
Molecular Pathogenesis
Metal Binding Specificity of the MntABC Permease of Neisseria gonorrhoeae and Its Influence on Bacterial Growth and Interaction with Cervical Epithelial Cells
Karen H. L. Lim, Christopher E. Jones, Rachel N. vanden Hoven, Jennifer L. Edwards, Megan L. Falsetta, Michael A. Apicella, Michael P. Jennings, Alastair G. McEwan
Molecular Pathogenesis
Phenotypic and Genotypic Analyses of Neisseria gonorrhoeae Isolates That Express Frequently Recovered PorB PIA Variable Region Types Suggest that Certain P1a Porin Sequences Confer a Selective Advantage for Urogenital Tract Infection
Lotisha E. Garvin, Margaret C. Bash, Christine Keys, Douglas M. Warner, Sanjay Ram, William M. Shafer, Ann E. Jerse
Molecular Pathogenesis
The Capsule Sensitizes Streptococcus pneumoniae to α-Defensins Human Neutrophil Proteins 1 to 3
Katharina Beiter, Florian Wartha, Robert Hurwitz, Staffan Normark, Arturo Zychlinsky, Birgitta Henriques-Normark
Molecular Pathogenesis
Yersinia pestis Type III Secretion System-Dependent Inhibition of Human Polymorphonuclear Leukocyte Function
Justin L. Spinner, Jennifer A. Cundiff, Scott D. Kobayashi
Molecular Pathogenesis
Noncytotoxic Clostridium perfringens Enterotoxin (CPE) Variants Localize CPE Intestinal Binding and Demonstrate a Relationship between CPE-Induced Cytotoxicity and Enterotoxicity
James G. Smedley, Juliann Saputo, Jacquelyn C. Parker, Mariano E. Fernandez-Miyakawa, Susan L. Robertson, Bruce A. McClane, Francisco A. Uzal

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Epidermal Growth Factor Inhibits Campylobacter jejuni-Induced Claudin-4 Disruption, Loss of Epithelial Barrier Function, and Escherichia coli Translocation
Jennifer M. Lamb-Rosteski, Lisa D. Kalischuk, G. Douglas Inglis, Andre G. Buret
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
MglA and Igl Proteins Contribute to the Modulation of Francisella tularensis Live Vaccine Strain-Containing Phagosomes in Murine Macrophages
Linda Bönquist, Helena Lindgren, Igor Golovliov, Tina Guina, Anders Sjöstedt
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
A Triacylated Lipoprotein from Mycoplasma genitalium Activates NF-κB through Toll-Like Receptor 1 (TLR1) and TLR2
Takashi Shimizu, Yutaka Kida, Koichi Kuwano
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Shiga Toxin 2 Causes Apoptosis in Human Brain Microvascular Endothelial Cells via C/EBP Homologous Protein
Jun Fujii, Katie Wood, Fumiko Matsuda, Benedito A. Carneiro-Filho, Keilo H. Schlegel, Takashi Yutsudo, Beth Binnington-Boyd, Clifford A. Lingwood, Fumiko Obata, Kwang S. Kim, Shin-ichi Yoshida, Tom Obrig

Bacterial Infections

Bacterial Infections
Cathelicidin LL-37 in Severe Streptococcus pyogenes Soft Tissue Infections in Humans
Linda Johansson, Pontus Thulin, Parham Sendi, Erika Hertzén, Adam Linder, Per Åkesson, Donald E. Low, Birgitta Agerberth, Anna Norrby-Teglund
Bacterial Infections
Hypercholesterolemia Impairs Immunity to Tuberculosis
Gregory W. Martens, Meltem Cevik Arikan, Jinhee Lee, Fucheng Ren, Therese Vallerskog, Hardy Kornfeld
Bacterial Infections
Identification of fevR, a Novel Regulator of Virulence Gene Expression in Francisella novicida
Anna Brotcke, Denise M. Monack
Bacterial Infections
Rat Pneumonia and Soft-Tissue Infection Models for the Study of Acinetobacter baumannii Biology
Thomas A. Russo, Janet M. Beanan, Ruth Olson, Ulrike MacDonald, Nicole R. Luke, Steven R. Gill, Anthony A. Campagnari
Bacterial Infections
d-Alanylation of Lipoteichoic Acid Contributes to the Virulence of Streptococcus suis
Nahuel Fittipaldi, Tsutomu Sekizaki, Daisuke Takamatsu, Josée Harel, María de la Cruz Domínguez-Punaro, Sonja Von Aulock, Christian Draing, Corinne Marois, Marylène Kobisch, Marcelo Gottschalk
Bacterial Infections
Vibrio cholerae RND Family Efflux Systems Are Required for Antimicrobial Resistance, Optimal Virulence Factor Production, and Colonization of the Infant Mouse Small Intestine
Xiaowen R. Bina, Daniele Provenzano, Nathalie Nguyen, James E. Bina
Bacterial Infections
Combined Deletion of Four Francisella novicida Acid Phosphatases Attenuates Virulence and Macrophage Vacuolar Escape
Nrusingh P. Mohapatra, Shilpa Soni, Thomas J. Reilly, Jirong Liu, Karl E. Klose, John S. Gunn
Bacterial Infections
The Absence of Toll-Like Receptor 4 Signaling in C3H/HeJ Mice Predisposes Them to Overwhelming Rickettsial Infection and Decreased Protective Th1 Responses
Jeffrey M. Jordan, Michael E. Woods, Juan Olano, David H. Walker
Bacterial Infections
Differential Activation of Human and Mouse Toll-Like Receptor 4 by the Adjuvant Candidate LpxL1 of Neisseria meningitidis
Liana Steeghs, A. Marijke Keestra, Andries van Mourik, Heli Uronen-Hansson, Peter van der Ley, Robin Callard, Nigel Klein, Jos P. M. van Putten
Bacterial Infections
The Fibrinogen- and Fibronectin-Binding Domains of Staphylococcus aureus Fibronectin-Binding Protein A Synergistically Promote Endothelial Invasion and Experimental Endocarditis
Lionel Piroth, Yok-Ai Que, Eleonora Widmer, Alexandre Panchaud, Stéphane Piu, José M. Entenza, Philippe Moreillon

Host Response and Inflammation

Host Response and Inflammation
Proteomic Analysis of and Immune Responses to Ehrlichia chaffeensis Lipoproteins
Haibin Huang, Mingqun Lin, Xueqi Wang, Takane Kikuchi, Heather Mottaz, Angela Norbeck, Yasuko Rikihisa
Host Response and Inflammation
Mutans Streptococcal Infection Induces Salivary Antibody to Virulence Proteins and Associated Functional Domains
R. D. Nogueira, W. F. King, G. Gunda, S. Culshaw, M. A. Taubman, R. O. Mattos-Graner, D. J. Smith
Host Response and Inflammation
Distinct Isoforms of Phospholipase A₂ Mediate the Ability of Salmonella enterica Serotype Typhimurium and Shigella flexneri To Induce the Transepithelial Migration of Neutrophils
Karen L. Mumy, Jeffrey D. Bien, Michael A. Pazos, Karsten Gronert, Bryan P. Hurley, Beth A. McCormick
Host Response and Inflammation
Interleukin-12 (IL-12) and IL-23 Induction of Substance P Synthesis in Murine T Cells and Macrophages Is Subject to IL-10 and Transforming Growth Factor β Regulation
Arthur Blum, Tommy Setiawan, Long Hang, Korynn Stoyanoff, Joel V. Weinstock
Host Response and Inflammation
An Interleukin-1β (IL-1β) Single-Nucleotide Polymorphism at Position 3954 and Red Complex Periodontopathogens Independently and Additively Modulate the Levels of IL-1β in Diseased Periodontal Tissues
Samuel B. Ferreira, Ana Paula F. Trombone, Carlos E. Repeke, Cristina R. Cardoso, Walter Martins, Carlos F. Santos, Paula Cristina Trevilatto, Mario J. Ávila-Campos, Ana Paula Campanelli, João S. Silva, Gustavo P. Garlet

Fungal and Parasitic Infections

Fungal and Parasitic Infections
The Chlamydial Plasmid-Encoded Protein pgp3 Is Secreted into the Cytosol of Chlamydia-Infected Cells
Zhongyu Li, Ding Chen, Youmin Zhong, Shiping Wang, Guangming Zhong
Fungal and Parasitic Infections
Aspergillus fumigatus Stimulates Leukocyte Adhesion Molecules and Cytokine Production by Endothelial Cells In Vitro and during Invasive Pulmonary Disease
Lisa Y. Chiang, Donald C. Sheppard, Fabrice N. Gravelat, Thomas F. Patterson, Scott G. Filler
Fungal and Parasitic Infections
Pneumocystis murina Infection and Cigarette Smoke Exposure Interact To Cause Increased Organism Burden, Development of Airspace Enlargement, and Pulmonary Inflammation in Mice
Paul J. Christensen, Angela M. Preston, Tony Ling, Ming Du, W. Bradley Fields, Jeffrey L. Curtis, James M. Beck
Fungal and Parasitic Infections
Temporal and Spatial Distribution of Toxoplasma gondii Differentiation into Bradyzoites and Tissue Cyst Formation In Vivo
Manlio Di Cristina, Daniela Marocco, Roberto Galizi, Carla Proietti, Roberta Spaccapelo, Andrea Crisanti
Fungal and Parasitic Infections
Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung
Joshua J. Reece, Mark C. Siracusa, Teresa L. Southard, Cory F. Brayton, Joseph F. Urban, Alan L. Scott
Fungal and Parasitic Infections
Persistently Infected Horses Are Reservoirs for Intrastadial Tick-Borne Transmission of the Apicomplexan Parasite Babesia equi
Massaro W. Ueti, Guy H. Palmer, Glen A. Scoles, Lowell S. Kappmeyer, Donald P. Knowles
Fungal and Parasitic Infections
A Novel Immunoprecipitation Strategy Identifies a Unique Functional Mimic of the Glial Cell Line-Derived Neurotrophic Factor Family Ligands in the Pathogen Trypanosoma cruzi
Bo Lu, Mercio PereiraPerrin
Fungal and Parasitic Infections
Effector CD8⁺ T Lymphocytes against Liver Stages of Plasmodium yoelii Do Not Require Gamma Interferon for Antiparasite Activity
Sumana Chakravarty, G. Christian Baldeviano, Michael G. Overstreet, Fidel Zavala
Fungal and Parasitic Infections
In Vivo Analysis of Aspergillus fumigatus Developmental Gene Expression Determined by Real-Time Reverse Transcription-PCR
Fabrice N. Gravelat, Thomas Doedt, Lisa Y. Chiang, Hong Liu, Scott G. Filler, Thomas F. Patterson, Donald C. Sheppard
Fungal and Parasitic Infections
Cooperative Role of Macrophages and Neutrophils in Host Antiprotozoan Resistance in Mice Acutely Infected with Cryptosporidium parvum
Dan Takeuchi, Vickie C. Jones, Makiko Kobayashi, Fujio Suzuki
Fungal and Parasitic Infections
The Terminal Sialic Acid of Glycoconjugates on the Surface of Intestinal Epithelial Cells Activates Excystation of Cryptosporidium parvum
Naheed Choudhry, Mona Bajaj-Elliott, Vincent McDonald
Fungal and Parasitic Infections
Inhibition of Apoptosis in Cryptosporidium parvum-Infected Intestinal Epithelial Cells Is Dependent on Survivin
Jin Liu, Shinichiro Enomoto, Cheryl A. Lancto, Mitchell S. Abrahamsen, Mark S. Rutherford

Microbial Immunity and Vaccines

Microbial Immunity and Vaccines
Selected prfA* Mutations in Recombinant Attenuated Listeria monocytogenes Strains Augment Expression of Foreign Immunogens and Enhance Vaccine-Elicited Humoral and Cellular Immune Responses
Lin Yan, Jin Qiu, Jianbo Chen, Bridgett Ryan-Payseur, Dan Huang, Yunqi Wang, Lijun Rong, Jody A. Melton-Witt, Nancy E. Freitag, Zheng W. Chen
Microbial Immunity and Vaccines
Effective Plague Vaccination via Oral Delivery of Plant Cells Expressing F1-V Antigens in Chloroplasts
Philip A. Arlen, Michael Singleton, Jeffrey J. Adamovicz, Yi Ding, Abdolreza Davoodi-Semiromi, Henry Daniell
Microbial Immunity and Vaccines
Native Outer Membrane Proteins Protect Mice against Pulmonary Challenge with Virulent Type A Francisella tularensis
Jason F. Huntley, Patrick G. Conley, David A. Rasko, Kayla E. Hagman, Michael A. Apicella, Michael V. Norgard
Microbial Immunity and Vaccines
Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains
Peter Lauer, Bill Hanson, Edward E. Lemmens, Weiqun Liu, William S. Luckett, Meredith L. Leong, Heather E. Allen, Justin Skoble, Keith S. Bahjat, Nancy E. Freitag, Dirk G. Brockstedt, Thomas W. Dubensky
Microbial Immunity and Vaccines
Impaired Opsonization with C3b and Phagocytosis of Streptococcus pneumoniae in Sera from Subjects with Defects in the Classical Complement Pathway
Jose Yuste, Ashwin Sen, Lennart Truedsson, Göran Jönsson, Liang-Seah Tay, Catherine Hyams, Helen E. Baxendale, Fiona Goldblatt, Marina Botto, Jeremy S. Brown
Microbial Immunity and Vaccines
Oral Vaccination of Guinea Pigs with a Mycobacterium bovis Bacillus Calmette-Guérin Vaccine in a Lipid Matrix Protects against Aerosol Infection with Virulent M. bovis
Simon Clark, Martin L. Cross, Allan Nadian, Julia Vipond, Pinar Court, Ann Williams, R. Glyn Hewinson, Frank E. Aldwell, Mark A. Chambers
Microbial Immunity and Vaccines
Immunization with a Toll-Like Receptor 7 and/or 8 Agonist Vaccine Adjuvant Increases Protective Immunity against Leishmania major in BALB/c Mice
Wen-Wei Zhang, Greg Matlashewski
Microbial Immunity and Vaccines
Oral Vaccination against Bubonic Plague Using a Live Avirulent Yersinia pseudotuberculosis Strain
Thierry Blisnick, Patrick Ave, Michel Huerre, Elisabeth Carniel, Christian E. Demeure
Microbial Immunity and Vaccines
The Oligomerization Domain of C4-Binding Protein (C4bp) Acts as an Adjuvant, and the Fusion Protein Comprised of the 19-Kilodalton Merozoite Surface Protein 1 Fused with the Murine C4bp Domain Protects Mice against Malaria
Solabomi A. Ogun, Laurence Dumon-Seignovert, Jean-Baptiste Marchand, Anthony A. Holder, Fergal Hill

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Table of Contents

Spotlight

Minireviews

Molecular Pathogenesis

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Bacterial Infections

Host Response and Inflammation

Fungal and Parasitic Infections

Microbial Immunity and Vaccines

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