Infection and Immunity: 77 (10)

October 2009; Volume 77,Issue 10

Editorial

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Editorial
Important Science—It's All about the SPIN
Arturo Casadevall, Ferric C. Fang

Spotlight

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Spotlight
Articles of Significant Interest Selected from This Issue by the Editors

Commentary

Commentary
The Case for Developing Consensus Standards for Research in Microbial Pathogenesis: Bacillus anthracis Toxins as an Example
Molly A. Hughes, Drusilla L. Burns, Stephen J. Juris, Wei-Jen Tang, Kristin H. Clement, Linda J. Eaton, Cassandra D. Kelly-Cirino, Marian L. McKee, Bradford S. Powell, Brian L. Bishop, Thomas L. Rudge, Nancy Shine, Anita Verma, Melissa Swope Willis, Stephen A. Morse

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Porphyromonas gingivalis Outer Membrane Vesicles Enter Human Epithelial Cells via an Endocytic Pathway and Are Sorted to Lysosomal Compartments
Nobumichi Furuta, Kayoko Tsuda, Hiroko Omori, Tamotsu Yoshimori, Fuminobu Yoshimura, Atsuo Amano
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Nontypeable Haemophilus influenzae Clearance by Alveolar Macrophages Is Impaired by Exposure to Cigarette Smoke
Pau Martí-Lliteras, Verónica Regueiro, Pau Morey, Derek W. Hood, Carles Saus, Jaume Sauleda, Alvar G. N. Agustí, José Antonio Bengoechea, Junkal Garmendia
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Nuclear Translocated Ehrlichia chaffeensis Ankyrin Protein Interacts with a Specific Adenine-Rich Motif of Host Promoter and Intronic Alu Elements
Bing Zhu, Kimberly A. Nethery, Jeeba A. Kuriakose, Abdul Wakeel, Xiaofeng Zhang, Jere W. McBride
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
CA-074Me Protection against Anthrax Lethal Toxin
Zachary L. Newman, Stephen H. Leppla, Mahtab Moayeri
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Expression of Nlrp1b Inflammasome Components in Human Fibroblasts Confers Susceptibility to Anthrax Lethal Toxin
Kuo-Chieh Liao, Jeremy Mogridge
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Interactions of Enteropathogenic Escherichia coli with Pediatric and Adult Intestinal Biopsy Specimens during Early Adherence
Romney M. Humphries, Christopher C. M. Waterhouse, George Mulvey, Paul Beck, Glen D. Armstrong
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Role of Phosphatidylinositol Mannosides in the Interaction between Mycobacteria and DC-SIGN
Nicole N. Driessen, Roy Ummels, Janneke J. Maaskant, Sudagar S. Gurcha, Gurdyal S. Besra, Gary D. Ainge, David S. Larsen, Gavin F. Painter, Christina M. J. E. Vandenbroucke-Grauls, Jeroen Geurtsen, Ben J. Appelmelk
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Mycobacterium tuberculosis Cell Wall Glycolipids Directly Inhibit CD4⁺ T-Cell Activation by Interfering with Proximal T-Cell-Receptor Signaling
Robert N. Mahon, Roxana E. Rojas, Scott A. Fulton, Jennifer L. Franko, Clifford V. Harding, W. Henry Boom
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Hag Mediates Adherence of Moraxella catarrhalis to Ciliated Human Airway Cells
Rachel Balder, Thomas M. Krunkosky, Chi Q. Nguyen, Lacey Feezel, Eric R. Lafontaine
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Actin Dynamics and Rho GTPases Regulate the Size and Formation of Parasitophorous Vacuoles Containing Coxiella burnetii
Milton Aguilera, Romina Salinas, Eliana Rosales, Sergio Carminati, Maria I. Colombo, Walter Berón

Molecular Pathogenesis

Molecular Pathogenesis
Establishment of Systemic Brucella melitensis Infection through the Digestive Tract Requires Urease, the Type IV Secretion System, and Lipopolysaccharide O Antigen
Tatiane A. Paixão, Christelle M. Roux, Andreas B. den Hartigh, Sumathi Sankaran-Walters, Satya Dandekar, Renato L. Santos, Renée M. Tsolis
Molecular Pathogenesis
Characterization of the Effects of Salicylidene Acylhydrazide Compounds on Type III Secretion in Escherichia coli O157:H7
Jai J. Tree, Dai Wang, Carol McInally, Arvind Mahajan, Abigail Layton, Irene Houghton, Mikael Elofsson, Mark P. Stevens, David L. Gally, Andrew J. Roe
Molecular Pathogenesis
Microarray and Functional Analysis of Growth Phase-Dependent Gene Regulation in Bordetella bronchiseptica
Tracy L. Nicholson, Anne M. Buboltz, Eric T. Harvill, Susan L. Brockmeier
Molecular Pathogenesis
Characterization of a Unique ADP-Ribosyltransferase of Mycoplasma penetrans
Coreen Johnson, T. R. Kannan, Joel B. Baseman
Molecular Pathogenesis
Comparative Analysis of the Properties and Ligand Binding Characteristics of CspZ, a Factor H Binding Protein, Derived from Borrelia burgdorferi Isolates of Human Origin
Elizabeth A. Rogers, Shane V. Abdunnur, John V. McDowell, Richard T. Marconi
Molecular Pathogenesis
The Flagella of an Atypical Enteropathogenic Escherichia coli Strain Are Required for Efficient Interaction with and Stimulation of Interleukin-8 Production by Enterocytes In Vitro
Suely C. F. Sampaio, Tânia A. T. Gomes, Christophe Pichon, Laurence du Merle, Stéphanie Guadagnini, Cecilia M. Abe, Jorge L. M. Sampaio, Chantal Le Bouguénec
Molecular Pathogenesis
Identification of a Gingipain-Sensitive Surface Ligand of Porphyromonas gingivalis That Induces Toll-Like Receptor 2- and 4-Independent NF-κB Activation in CHO Cells
Koki Haruyama, Atsutoshi Yoshimura, Mariko Naito, Mami Kishimoto, Mikio Shoji, Yoshimitsu Abiko, Yoshitaka Hara, Koji Nakayama
Molecular Pathogenesis
The NanI and NanJ Sialidases of Clostridium perfringens Are Not Essential for Virulence
Martina Chiarezza, Dena Lyras, Sacha J. Pidot, Marietta Flores-Díaz, Milena M. Awad, Catherine L. Kennedy, Leanne M. Cordner, Tongted Phumoonna, Rachael Poon, Meredith L. Hughes, John J. Emmins, Alberto Alape-Girón, Julian I. Rood
Molecular Pathogenesis
The 58-Kilodalton Major Virulence Factor of Francisella tularensis Is Required for Efficient Utilization of Iron
Helena Lindgren, Marie Honn, Igor Golovlev, Konstantin Kadzhaev, Wayne Conlan, Anders Sjöstedt
Molecular Pathogenesis
The Global Regulator CodY Regulates Toxin Gene Expression in Bacillus anthracis and Is Required for Full Virulence
Willem van Schaik, Alice Château, Marie-Agnès Dillies, Jean-Yves Coppée, Abraham L. Sonenshein, Agnès Fouet
Molecular Pathogenesis
Nitrite Reductase NirS Is Required for Type III Secretion System Expression and Virulence in the Human Monocyte Cell Line THP-1 by Pseudomonas aeruginosa
Nadine E. Van Alst, Melanie Wellington, Virginia L. Clark, Constantine G. Haidaris, Barbara H. Iglewski
Molecular Pathogenesis
The Transcriptional Regulator Rv0485 Modulates the Expression of a pe and ppe Gene Pair and Is Required for Mycobacterium tuberculosis Virulence
Rachael M. Goldstone, Sunali D. Goonesekera, Barry R. Bloom, Samantha L. Sampson

Bacterial Infections

Bacterial Infections
Tricarboxylic Acid Cycle-Dependent Attenuation of Staphylococcus aureus In Vivo Virulence by Selective Inhibition of Amino Acid Transport
Yefei Zhu, Yan Q. Xiong, Marat R. Sadykov, Paul D. Fey, Mei G. Lei, Chia Y. Lee, Arnold S. Bayer, Greg A. Somerville
Bacterial Infections
Complicated Urinary Tract Infection Is Associated with Uroepithelial Expression of Proinflammatory Protein S100A8
Leticia Reyes, Sophie Alvarez, Ayman Allam, Mary Reinhard, Mary B. Brown
Bacterial Infections
Burkholderia pseudomallei Isocitrate Lyase Is a Persistence Factor in Pulmonary Melioidosis: Implications for the Development of Isocitrate Lyase Inhibitors as Novel Antimicrobials
Erin J. van Schaik, Marina Tom, Donald E. Woods
Bacterial Infections
Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease
Adrian M. Zelazny, Li Ding, Houda Z. Elloumi, Lauren R. Brinster, Fran Benedetti, Meggan Czapiga, Ricky L. Ulrich, Samuel J. Ballentine, Joanna B. Goldberg, Elizabeth P. Sampaio, Steven M. Holland
Bacterial Infections
Recombinant Listeria monocytogenes Expressing a Cell Wall-Associated Listeriolysin O Is Weakly Virulent but Immunogenic
Javier A. Carrero, Boris Calderon, Hector Vivanco-Cid, Emil R. Unanue
Bacterial Infections
Flagellum-Mediated Biofilm Defense Mechanisms of Pseudomonas aeruginosa against Host-Derived Lactoferrin
Jeff G. Leid, Mathias Kerr, Candice Selgado, Chelsa Johnson, Gabriel Moreno, Alyssa Smith, Mark E. Shirtliff, George A. O'Toole, Emily K. Cope
Bacterial Infections
Community-Wide Response of the Gut Microbiota to Enteropathogenic Citrobacter rodentium Infection Revealed by Deep Sequencing
Christian Hoffmann, David A. Hill, Nana Minkah, Thomas Kirn, Amy Troy, David Artis, Frederic Bushman

Fungal and Parasitic Infections

Fungal and Parasitic Infections
Cryptococcus gattii Isolates from the British Columbia Cryptococcosis Outbreak Induce Less Protective Inflammation in a Murine Model of Infection than Cryptococcus neoformans
Po-Yan Cheng, Anita Sham, James W. Kronstad
Fungal and Parasitic Infections
Spores as Infectious Propagules of Cryptococcus neoformans
Rajesh Velagapudi, Yen-Ping Hsueh, Scarlett Geunes-Boyer, Jo Rae Wright, Joseph Heitman
Fungal and Parasitic Infections
Indoleamine 2,3-Dioxygenase Is Involved in Defense against Neospora caninum in Human and Bovine Cells
Katrin Spekker, Markus Czesla, Vanessa Ince, Kathrin Heseler, Silvia K. Schmidt, Gereon Schares, Walter Däubener
Fungal and Parasitic Infections
Plasmodium falciparum-Specific Cellular Immune Responses after Immunization with the RTS,S/AS02D Candidate Malaria Vaccine in Infants Living in an Area of High Endemicity in Mozambique
Arnoldo Barbosa, Denise Naniche, John J. Aponte, M. Nelia Manaca, Inacio Mandomando, Pedro Aide, Jahit Sacarlal, Montse Renom, Sarah Lafuente, W. Ripley Ballou, Pedro L. Alonso
Fungal and Parasitic Infections
The Trehalose Synthesis Pathway Is an Integral Part of the Virulence Composite for Cryptococcus gattii
Popchai Ngamskulrungroj, Uwe Himmelreich, Julia A. Breger, Christabel Wilson, Methee Chayakulkeeree, Mark B. Krockenberger, Richard Malik, Heide-Marie Daniel, Dena Toffaletti, Julianne T. Djordjevic, Eleftherios Mylonakis, Wieland Meyer, John R. Perfect

Microbial Immunity and Vaccines

Microbial Immunity and Vaccines
D27-pLpxL, an Avirulent Strain of Yersinia pestis, Primes T Cells That Protect against Pneumonic Plague
Frank M. Szaba, Lawrence W. Kummer, Lindsey B. Wilhelm, Jr-Shiuan Lin, Michelle A. Parent, Sara W. Montminy-Paquette, Egil Lien, Lawrence L. Johnson, Stephen T. Smiley
Microbial Immunity and Vaccines
Antibody Protection against Botulinum Neurotoxin Intoxication in Mice
Luisa W. Cheng, Larry H. Stanker, Thomas D. Henderson, Jianlong Lou, James D. Marks
Microbial Immunity and Vaccines
Vaccination with an Attenuated Strain of Francisella novicida Prevents T-Cell Depletion and Protects Mice Infected with the Wild-Type Strain from Severe Sepsis
Jyotika Sharma, Qun Li, Bibhuti B. Mishra, Michelle J. Georges, Judy M. Teale
Microbial Immunity and Vaccines
High-Throughput Identification of New Protective Antigens from a Yersinia pestis Live Vaccine by Enzyme-Linked Immunospot Assay
Bei Li, Lei Zhou, JingYu Guo, Xiaoyi Wang, Bin Ni, Yuehua Ke, Ziwen Zhu, Zhaobiao Guo, Ruifu Yang
Microbial Immunity and Vaccines
Perforin and Gamma Interferon Expression Are Required for CD4⁺ and CD8⁺ T-Cell-Dependent Protective Immunity against a Human Parasite, Trypanosoma cruzi, Elicited by Heterologous Plasmid DNA Prime-Recombinant Adenovirus 5 Boost Vaccination
Bruna C. G. de Alencar, Pedro M. Persechini, Filipe A. Haolla, Gabriel de Oliveira, Jaline C. Silverio, Joseli Lannes-Vieira, Alexandre V. Machado, Ricardo T. Gazzinelli, Oscar Bruna-Romero, Mauricio M. Rodrigues
Microbial Immunity and Vaccines
Inhibitory Antibodies Specific for the 19-Kilodalton Fragment of Merozoite Surface Protein 1 Do Not Correlate with Delayed Appearance of Infection with Plasmodium falciparum in Semi-Immune Individuals in Vietnam
E. Elsa Herdiana Murhandarwati, Lina Wang, Casilda G. Black, Doan Hanh Nhan, Thomas L. Richie, Ross L. Coppel
Microbial Immunity and Vaccines
PspA Family Fusion Proteins Delivered by Attenuated Salmonella enterica Serovar Typhimurium Extend and Enhance Protection against Streptococcus pneumoniae
Wei Xin, Yuhua Li, Hua Mo, Kenneth L. Roland, Roy Curtiss
Microbial Immunity and Vaccines
Nod1/Nod2-Mediated Recognition Plays a Critical Role in Induction of Adaptive Immunity to Anthrax after Aerosol Exposure
Crystal L. Loving, Manuel Osorio, Yun-Gi Kim, Gabriel Nuñez, Molly A. Hughes, Tod J. Merkel
Microbial Immunity and Vaccines
Use of Moraxella catarrhalis Lipooligosaccharide Mutants To Identify Specific Oligosaccharide Epitopes Recognized by Human Serum Antibodies
Johanna M. Schwingel, Katie J. Edwards, Andrew D. Cox, Hussein Masoud, James C. Richards, Frank St. Michael, Carmen D. Tekwe, Sanjay Sethi, Timothy F. Murphy, Anthony A. Campagnari
Microbial Immunity and Vaccines
Cytotoxicity and Secretion of Gamma Interferon Are Carried Out by Distinct CD8 T Cells during Mycobacterium tuberculosis Infection
Thorbjorg Einarsdottir, Euan Lockhart, JoAnne L. Flynn
Microbial Immunity and Vaccines
Antigen Display, T-Cell Activation, and Immune Evasion during Acute and Chronic Ehrlichiosis
Bisweswar Nandi, Madhumouli Chatterjee, Kathryn Hogle, Maura McLaughlin, Katherine MacNamara, Rachael Racine, Gary M. Winslow
Microbial Immunity and Vaccines
Investigation of New Dominant-Negative Inhibitors of Anthrax Protective Antigen Mutants for Use in Therapy and Vaccination
Sha Cao, Aizhen Guo, Ziduo Liu, Yadi Tan, Gaobing Wu, Chengcai Zhang, Yaxing Zhao, Huanchun Chen

Host Response and Inflammation

Host Response and Inflammation
Chlamydia muridarum-Specific CD4 T-Cell Clones Recognize Infected Reproductive Tract Epithelial Cells in an Interferon-Dependent Fashion
Krupakar Jayarapu, Micah S. Kerr, Adrian Katschke, Raymond M. Johnson
Host Response and Inflammation
Role of Nod1 in Mucosal Dendritic Cells during Salmonella Pathogenicity Island 1-Independent Salmonella enterica Serovar Typhimurium Infection
Lionel Le Bourhis, Joao Gamelas Magalhaes, Thirumahal Selvanantham, Leonardo H. Travassos, Kaoru Geddes, Jörg H. Fritz, Jérôme Viala, Karsten Tedin, Stephen E. Girardin, Dana J. Philpott
Host Response and Inflammation
Phagocytosis Inhibits F-Actin-Enriched Membrane Protrusions Stimulated by Fractalkine (CX3CL1) and Colony-Stimulating Factor 1
Yong Luo, Beth M. Isaac, Arturo Casadevall, Dianne Cox
Host Response and Inflammation
Uncoupling Scavenger Receptor A-Mediated Phagocytosis of Bacteria from Endotoxic Shock Resistance
Eyal Amiel, Julie L. Acker, Ryan M. Collins, Brent Berwin
Host Response and Inflammation
Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model
Philana Ling Lin, Mark Rodgers, Le'kneitah Smith, Matthew Bigbee, Amy Myers, Carolyn Bigbee, Ion Chiosea, Saverio V. Capuano, Carl Fuhrman, Edwin Klein, JoAnne L. Flynn

Retraction

Retraction
Directional Gene Movement from Human-Pathogenic to Commensal-Like Streptococci
Awdhesh Kalia, Mark C. Enright, Brian G. Spratt, Debra E. Bessen

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Table of Contents

Editorial

Spotlight

Commentary

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Molecular Pathogenesis

Bacterial Infections

Fungal and Parasitic Infections

Microbial Immunity and Vaccines

Host Response and Inflammation

Retraction

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