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Infection and Immunity
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Table of Contents

September 2009; Volume 77,Issue 9

Editorial

  • Free
    Editorial
    Mechanistic Science
    Arturo Casadevall, Ferric C. Fang

Spotlight

  • Free
    Spotlight
    Articles of Significant Interest Selected from This Issue by the Editors

Molecular Pathogenesis

  • Molecular Pathogenesis
    Transcriptional Profiling Identifies the Metabolic Phenotype of Gonococcal Biofilms
    Megan L. Falsetta, Thomas B. Bair, Shan Chi Ku, Rachel N. vanden Hoven, Christopher T. Steichen, Alastair G. McEwan, Michael P. Jennings, Michael A. Apicella
  • Molecular Pathogenesis
    Amino Acid Changes in Elongation Factor Tu of Mycoplasma pneumoniae and Mycoplasma genitalium Influence Fibronectin Binding
    Sowmya Balasubramanian, T. R. Kannan, P. John Hart, Joel B. Baseman
  • Molecular Pathogenesis
    Aggregatibacter actinomycetemcomitans Builds Mutualistic Biofilm Communities with Fusobacterium nucleatum and Veillonella Species in Saliva
    Saravanan Periasamy, Paul E. Kolenbrander
  • Molecular Pathogenesis
    The RNA Binding Protein CsrA Is a Pleiotropic Regulator of the Locus of Enterocyte Effacement Pathogenicity Island of Enteropathogenic Escherichia coli
    Shantanu Bhatt, Adrianne Nehrling Edwards, Hang Thi Thu Nguyen, Didier Merlin, Tony Romeo, Daniel Kalman
  • Molecular Pathogenesis
    Accelerated Type III Secretion System 2-Dependent Enteropathogenesis by a Salmonella enterica Serovar Enteritidis PT4/6 Strain
    Mrutyunjay Suar, Balamurugan Periaswamy, Pascal Songhet, Benjamin Misselwitz, Andreas Müller, Rina Käppeli, Marcus Kremer, Mathias Heikenwalder, Wolf-Dietrich Hardt
  • Molecular Pathogenesis
    The Meningococcal ABC-Type l-Glutamate Transporter GltT Is Necessary for the Development of Experimental Meningitis in Mice
    Roberta Colicchio, Susanna Ricci, Florentia Lamberti, Caterina Pagliarulo, Chiara Pagliuca, Velia Braione, Tiziana Braccini, Adelfia Talà, Donatella Montanaro, Sergio Tripodi, Marcella Cintorino, Giancarlo Troncone, Cecilia Bucci, Gianni Pozzi, Carmelo B. Bruni, Pietro Alifano, Paola Salvatore
  • Molecular Pathogenesis
    The NanA Neuraminidase of Streptococcus pneumoniae Is Involved in Biofilm Formation
    Dane Parker, Grace Soong, Paul Planet, Jonathan Brower, Adam J. Ratner, Alice Prince
  • Molecular Pathogenesis
    Further Characterization of the epa Gene Cluster and Epa Polysaccharides of Enterococcus faecalis
    Fang Teng, Kavindra V. Singh, Agathe Bourgogne, Jing Zeng, Barbara E. Murray
  • Molecular Pathogenesis
    Roles of RseB, σE, and DegP in Virulence and Phase Variation of Colony Morphotype of Vibrio vulnificus
    Roslyn N. Brown, Paul A. Gulig
  • Molecular Pathogenesis
    Outer Membrane Protein Expression Profile in Helicobacter pylori Clinical Isolates
    Stefan Odenbreit, Kirstin Swoboda, Iris Barwig, Stefan Ruhl, Thomas Borén, Sibylle Koletzko, Rainer Haas
  • Molecular Pathogenesis
    Human Serum Induces Streptococcal C5a Peptidase Expression
    Ute Gleich-Theurer, Simone Aymanns, Gregor Haas, Stefanie Mauerer, Julia Vogt, Barbara Spellerberg
  • Molecular Pathogenesis
    Shiga Toxin 1-Induced Proinflammatory Cytokine Production Is Regulated by the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Signaling Pathway
    Rama P. Cherla, Sang-Yun Lee, Renée A. Mulder, Moo-Seung Lee, Vernon L. Tesh
  • Molecular Pathogenesis
    Relevant Role of Fibronectin-Binding Proteins in Staphylococcus aureus Biofilm-Associated Foreign-Body Infections
    Marta Vergara-Irigaray, Jaione Valle, Nekane Merino, Cristina Latasa, Begoña García, Igor Ruiz de los Mozos, Cristina Solano, Alejandro Toledo-Arana, José R. Penadés, Iñigo Lasa
  • Molecular Pathogenesis
    Human α-Defensins Inhibit Hemolysis Mediated by Cholesterol-Dependent Cytolysins
    Robert I. Lehrer, Grace Jung, Piotr Ruchala, Wei Wang, Ewa D. Micewicz, Alan J. Waring, Eugene J. Gillespie, Kenneth A. Bradley, Adam J. Ratner, Richard F. Rest, Wuyuan Lu
  • Molecular Pathogenesis
    LuxS Promotes Biofilm Maturation and Persistence of Nontypeable Haemophilus influenzae In Vivo via Modulation of Lipooligosaccharides on the Bacterial Surface
    Chelsie E. Armbruster, Wenzhou Hong, Bing Pang, Kristin E. Dew, Richard A. Juneau, Matthew S. Byrd, Cheraton F. Love, Nancy D. Kock, W. Edward Swords
  • Molecular Pathogenesis
    Plasminogen Acquisition and Activation at the Surface of Leptospira Species Lead to Fibronectin Degradation
    Monica L. Vieira, Silvio A. Vasconcellos, Amane P. Gonçales, Zenaide M. de Morais, Ana L. T. O. Nascimento
  • Molecular Pathogenesis
    Identification of Specific and Universal Virulence Factors in Burkholderia cenocepacia Strains by Using Multiple Infection Hosts
    Susanne Uehlinger, Stephan Schwager, Steve P. Bernier, Kathrin Riedel, David T. Nguyen, Pamela A. Sokol, Leo Eberl
  • Molecular Pathogenesis
    Bicarbonate Induces Vibrio cholerae Virulence Gene Expression by Enhancing ToxT Activity
    Basel H. Abuaita, Jeffrey H. Withey

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Influenza A Virus Neuraminidase Enhances Meningococcal Adhesion to Epithelial Cells through Interaction with Sialic Acid-Containing Meningococcal Capsules
    Marie-Anne Rameix-Welti, Maria Leticia Zarantonelli, Dario Giorgini, Corinne Ruckly, Monica Marasescu, Sylvie van der Werf, Jean-Michel Alonso, Nadia Naffakh, Muhamed-Kheir Taha
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Injection of Staphylococcus aureus EDIN by the Bacillus anthracis Protective Antigen Machinery Induces Vascular Permeability
    Monica Rolando, Patrick Munro, Caroline Stefani, Patrick Auberger, Gilles Flatau, Emmanuel Lemichez
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Neisseria gonorrhoeae Infection Protects Human Endocervical Epithelial Cells from Apoptosis via Expression of Host Antiapoptotic Proteins
    S. A. Follows, J. Murlidharan, P. Massari, L. M. Wetzler, C. A. Genco
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Staphylococcal Alpha-Toxin Is Not Sufficient To Mediate Escape from Phagolysosomes in Upper-Airway Epithelial Cells
    Bernd Giese, Silvia Dittmann, Kerstin Paprotka, Katja Levin, Annett Weltrowski, Diana Biehler, Thiên-Trí Lâm, Bhanu Sinha, Martin J. Fraunholz
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    A Transmembrane Domain-Containing Surface Protein from Toxoplasma gondii Augments Replication in Activated Immune Cells and Establishment of a Chronic Infection
    Angela M. Pollard, Sini Skariah, Dana G. Mordue, Laura J. Knoll
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    The RD1 Locus in the Mycobacterium tuberculosis Genome Contributes to Activation of Caspase-1 via Induction of Potassium Ion Efflux in Infected Macrophages
    Takeshi Kurenuma, Ikuo Kawamura, Hideki Hara, Ryosuke Uchiyama, Sylvia Daim, Sita Ramyamali Dewamitta, Shunsuke Sakai, Kohsuke Tsuchiya, Takamasa Nomura, Masao Mitsuyama
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Anaplasma phagocytophilum Dense-Cored Organisms Mediate Cellular Adherence through Recognition of Human P-Selectin Glycoprotein Ligand 1
    Matthew J. Troese, Jason A. Carlyon

Bacterial Infections

  • Bacterial Infections
    Contribution of Autolysin and Sortase A during Enterococcus faecalis DNA-Dependent Biofilm Development
    Pascale S. Guiton, Chia S. Hung, Kimberly A. Kline, Robyn Roth, Andrew L. Kau, Ericka Hayes, John Heuser, Karen W. Dodson, Michael G. Caparon, Scott J. Hultgren
  • Bacterial Infections
    Decreased Expression of Colonic Slc26a3 and Carbonic Anhydrase IV as a Cause of Fatal Infectious Diarrhea in Mice
    Diana Borenshtein, Katherine A. Schlieper, Barry H. Rickman, Jeannie M. Chapman, Clifford W. Schweinfest, James G. Fox, David B. Schauer
  • Bacterial Infections
    Real-Time Observation of Listeria monocytogenes-Phagocyte Interactions in Living Zebrafish Larvae
    Jean-Pierre Levraud, Olivier Disson, Karima Kissa, Isabelle Bonne, Pascale Cossart, Philippe Herbomel, Marc Lecuit
  • Bacterial Infections
    Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts
    Trevor D. Lawley, Simon Clare, Alan W. Walker, David Goulding, Richard A. Stabler, Nicholas Croucher, Piero Mastroeni, Paul Scott, Claire Raisen, Lynda Mottram, Neil F. Fairweather, Brendan W. Wren, Julian Parkhill, Gordon Dougan
  • Bacterial Infections
    Inhibition of Staphylococcus epidermidis Biofilm Formation by Rabbit Polyclonal Antibodies against the SesC Protein
    Mohammad Shahrooei, Vishal Hira, Benoit Stijlemans, Rita Merckx, Peter W. M. Hermans, Johan Van Eldere
  • Bacterial Infections
    Sialic Acid Catabolism Confers a Competitive Advantage to Pathogenic Vibrio cholerae in the Mouse Intestine
    Salvador Almagro-Moreno, E. Fidelma Boyd
  • Bacterial Infections
    Infection with Anaplasma phagocytophilum Induces Multilineage Alterations in Hematopoietic Progenitor Cells and Peripheral Blood Cells
    J. L. Johns, K. C. MacNamara, N. J. Walker, G. M. Winslow, D. L. Borjesson

Fungal and Parasitic Infections

  • Fungal and Parasitic Infections
    Complement C3 Plays an Essential Role in the Control of Opportunistic Fungal Infections
    S. Vicky Tsoni, Ann M. Kerrigan, Mohlopheni J. Marakalala, Naren Srinivasan, Maureen Duffield, Philip R. Taylor, Marina Botto, Chad Steele, Gordon D. Brown
  • Fungal and Parasitic Infections
    Toxoplasma gondii Cyclophilin 18-Mediated Production of Nitric Oxide Induces Bradyzoite Conversion in a CCR5-Dependent Manner
    Hany M. Ibrahim, Hiroshi Bannai, Xuenan Xuan, Yoshifumi Nishikawa
  • Fungal and Parasitic Infections
    Streptococcus gordonii Modulates Candida albicans Biofilm Formation through Intergeneric Communication
    Caroline V. Bamford, Anita d'Mello, Angela H. Nobbs, Lindsay C. Dutton, M. Margaret Vickerman, Howard F. Jenkinson
  • Fungal and Parasitic Infections
    Role of Dendritic Cells and Alveolar Macrophages in Regulating Early Host Defense against Pulmonary Infection with Cryptococcus neoformans
    John J. Osterholzer, Jami E. Milam, Gwo-Hsiao Chen, Galen B. Toews, Gary B. Huffnagle, Michal A. Olszewski
  • Fungal and Parasitic Infections
    Functional and Immunological Characterization of a Duffy Binding-Like Alpha Domain from Plasmodium falciparum Erythrocyte Membrane Protein 1 That Mediates Rosetting
    Alfredo Mayor, Eduard Rovira-Vallbona, Anand Srivastava, Surya K. Sharma, Sudhanshu S. Pati, Laura Puyol, Llorenç Quinto, Quique Bassat, Sonia Machevo, Inacio Mandomando, Virander S. Chauhan, Pedro L. Alonso, Chetan E. Chitnis
  • Fungal and Parasitic Infections
    Suppression of a Novel Hematopoietic Mediator in Children with Severe Malarial Anemia
    Christopher C. Keller, Collins Ouma, Yamo Ouma, Gordon A. Awandare, Gregory C. Davenport, Tom Were, James B. Hittner, John M. Vulule, John M. Ong'echa, Douglas J. Perkins
  • Fungal and Parasitic Infections
    Adhesion of Candida albicans to Endothelial Cells under Physiological Conditions of Flow
    Sarah E. W. Grubb, Craig Murdoch, Peter E. Sudbery, Stephen P. Saville, Jose L. Lopez-Ribot, Martin H. Thornhill
  • Fungal and Parasitic Infections
    Transmembrane Tumor Necrosis Factor Alpha Is Required for Enteropathy and Is Sufficient To Promote Parasite Expulsion in Gastrointestinal Helminth Infection
    M. X. Ierna, H. E. Scales, C. Mueller, C. E. Lawrence
  • Fungal and Parasitic Infections
    Loa loa Microfilariae Evade Complement Attack In Vivo by Acquiring Regulatory Proteins from Host Plasma
    Karita Haapasalo, Taru Meri, T. Sakari Jokiranta
  • Fungal and Parasitic Infections
    Clinical Chemistry of Congenic Mice with Quantitative Trait Loci for Predicted Responses to Trypanosoma congolense Infection
    Birgit Rathkolb, Harry A. Noyes, Andy Brass, Paul Dark, Helmut Fuchs, Valérie Gailus-Durner, John Gibson, Martin Hrabé de Angelis, Moses Ogugo, Fuad Iraqi, Steve J. Kemp, Jan Naessens, Mathew E. Pope, Eckhard Wolf, Morris Agaba
  • Fungal and Parasitic Infections
    A Regulator of Aspergillus fumigatus Extracellular Proteolytic Activity Is Dispensable for Virulence
    Anna Bergmann, Thomas Hartmann, Timothy Cairns, Elaine M. Bignell, Sven Krappmann
  • Fungal and Parasitic Infections
    Transcription Factor PrtT Controls Expression of Multiple Secreted Proteases in the Human Pathogenic Mold Aspergillus fumigatus
    Haim Sharon, Shelly Hagag, Nir Osherov
  • Fungal and Parasitic Infections
    Vaginal Microbiota of Women with Frequent Vulvovaginal Candidiasis
    Xia Zhou, Rachel Westman, Roxana Hickey, Melanie A. Hansmann, Colleen Kennedy, Thomas W. Osborn, Larry J. Forney
  • Fungal and Parasitic Infections
    Macrophage-Mediated Responses to Candida albicans in Mice Expressing the Human Immunodeficiency Virus Type 1 Transgene
    Mathieu Goupil, Émilie Bélanger Trudelle, Véronique Dugas, Catherine Racicot-Bergeron, Francine Aumont, Serge Sénéchal, Zaher Hanna, Paul Jolicoeur, Louis de Repentigny
  • Fungal and Parasitic Infections
    BAR Domain Proteins Rvs161 and Rvs167 Contribute to Candida albicans Endocytosis, Morphogenesis, and Virulence
    Lois M. Douglas, Stephen W. Martin, James B. Konopka

Microbial Immunity and Vaccines

  • Microbial Immunity and Vaccines
    Oligoclonal CD4+ T Cells Promote Host Memory Immune Responses to Zwitterionic Polysaccharide of Streptococcus pneumoniae
    Laura Groneck, David Schrama, Mario Fabri, Tom Li Stephen, Fabian Harms, Sonja Meemboor, Helena Hafke, Martina Bessler, Jürgen C. Becker, Wiltrud M. Kalka-Moll
  • Microbial Immunity and Vaccines
    Kinetics and Phenotype of Vaccine-Induced CD8+ T-Cell Responses to Toxoplasma gondii
    Kimberly A. Jordan, Emma H. Wilson, Elia D. Tait, Barbara A. Fox, David S. Roos, David J. Bzik, Florence Dzierszinski, Christopher A. Hunter
  • Microbial Immunity and Vaccines
    Novel Chimpanzee/Human Monoclonal Antibodies That Neutralize Anthrax Lethal Factor, and Evidence for Possible Synergy with Anti-Protective Antigen Antibody
    Zhaochun Chen, Mahtab Moayeri, Devorah Crown, Suzanne Emerson, Inna Gorshkova, Peter Schuck, Stephen H. Leppla, Robert H. Purcell
  • Microbial Immunity and Vaccines
    Protection against Intestinal Amebiasis by a Recombinant Vaccine Is Transferable by T Cells and Mediated by Gamma Interferon
    Xiaoti Guo, Lisa Barroso, Steven M. Becker, David M. Lyerly, Thomas S. Vedvick, Steven G. Reed, William A. Petri, Eric R. Houpt
  • Microbial Immunity and Vaccines
    Impact of Preexisting Vector-Specific Immunity on Vaccine Potency: Characterization of Listeria monocytogenes-Specific Humoral and Cellular Immunity in Humans and Modeling Studies Using Recombinant Vaccines in Mice
    Meredith L. Leong, Johannes Hampl, Weiqun Liu, Shruti Mathur, Keith S. Bahjat, William Luckett, Thomas W. Dubensky, Dirk G. Brockstedt
  • Microbial Immunity and Vaccines
    Strain-Specific Duffy Binding Protein Antibodies Correlate with Protection against Infection with Homologous Compared to Heterologous Plasmodium vivax Strains in Papua New Guinean Children
    Jennifer L. Cole-Tobian, Pascal Michon, Moses Biasor, Jack S. Richards, James G. Beeson, Ivo Mueller, Christopher L. King
  • Microbial Immunity and Vaccines
    Diminished Hematopoietic Activity Associated with Alterations in Innate and Adaptive Immunity in a Mouse Model of Human Monocytic Ehrlichiosis
    Katherine C. MacNamara, Rachael Racine, Madhumouli Chatterjee, Dori Borjesson, Gary M. Winslow
  • Microbial Immunity and Vaccines
    CT043, a Protective Antigen That Induces a CD4+ Th1 Response during Chlamydia trachomatis Infection in Mice and Humans
    Eva Meoni, Elisa Faenzi, Elisabetta Frigimelica, Luisanna Zedda, David Skibinski, Serena Giovinazzi, Alessandra Bonci, Roberto Petracca, Erika Bartolini, Giuliano Galli, Mauro Agnusdei, Filomena Nardelli, Francesca Buricchi, Nathalie Norais, Ilaria Ferlenghi, Manuela Donati, Roberto Cevenini, Oretta Finco, Guido Grandi, Renata Grifantini

Molecular Genomics

  • Molecular Genomics
    Analysis of the Genome of the Escherichia coli O157:H7 2006 Spinach-Associated Outbreak Isolate Indicates Candidate Genes That May Enhance Virulence
    Bridget R. Kulasekara, Michael Jacobs, Yang Zhou, Zaining Wu, Elizabeth Sims, Channakhone Saenphimmachak, Laurence Rohmer, Jennifer M. Ritchie, Matthew Radey, Matthew McKevitt, Theodore Larson Freeman, Hillary Hayden, Eric Haugen, Will Gillett, Christine Fong, Jean Chang, Viktoriya Beskhlebnaya, Matthew K. Waldor, Mansour Samadpour, Thomas S. Whittam, Rajinder Kaul, Mitchell Brittnacher, Samuel I. Miller
  • Molecular Genomics
    Role of the Type III Secretion System in a Hypervirulent Lineage of Bordetella bronchiseptica
    Anne M. Buboltz, Tracy L. Nicholson, Laura S. Weyrich, Eric T. Harvill
  • Molecular Genomics
    Genomic Analysis of an Attenuated Chlamydia abortus Live Vaccine Strain Reveals Defects in Central Metabolism and Surface Proteins
    L. S. Burall, A. Rodolakis, A. Rekiki, G. S. A. Myers, P. M. Bavoil

Host Response and Inflammation

  • Host Response and Inflammation
    Cellular Responses to Mycobacterial Antigens Are Present in Bronchoalveolar Lavage Fluid Used in the Diagnosis of Sarcoidosis
    Kyra A. Oswald-Richter, Daniel A. Culver, Charlene Hawkins, Rana Hajizadeh, Susamma Abraham, Bryan E. Shepherd, Cathy A. Jenkins, Marc A. Judson, Wonder P. Drake
  • Host Response and Inflammation
    Gr1+ Cells Control Growth of YopM-Negative Yersinia pestis during Systemic Plague
    Zhan Ye, Edward J. Kerschen, Donald A. Cohen, Alan M. Kaplan, Nico van Rooijen, Susan C. Straley
  • Host Response and Inflammation
    Streptococcus pneumoniae Autolysis Prevents Phagocytosis and Production of Phagocyte-Activating Cytokines
    Anna Martner, Susann Skovbjerg, James C. Paton, Agnes E. Wold
  • Host Response and Inflammation
    CD4+ CD25+ Foxp3− T-Regulatory Cells Produce both Gamma Interferon and Interleukin-10 during Acute Severe Murine Spotted Fever Rickettsiosis
    Rong Fang, Nahed Ismail, Thomas Shelite, David H. Walker
  • Host Response and Inflammation
    Antigen-Specific Memory B-Cell Responses to Vibrio cholerae O1 Infection in Bangladesh
    Aaron M. Harris, M. Saruar Bhuiyan, Fahima Chowdhury, Ashraful I. Khan, Azim Hossain, Emily A. Kendall, Atiqur Rahman, Regina C. LaRocque, Jens Wrammert, Edward T. Ryan, Firdausi Qadri, Stephen B. Calderwood, Jason B. Harris
  • Host Response and Inflammation
    Blockade of CD137 Signaling Counteracts Polymicrobial Sepsis Induced by Cecal Ligation and Puncture
    Quang-Tam Nguyen, Seong-A Ju, Sang-Min Park, Sang-Chul Lee, Hideo Yagita, In Hee Lee, Byung-Sam Kim
  • Host Response and Inflammation
    Involvement of Toll-Like Receptors 2 and 4 in the Innate Immune Response to Treponema denticola and Its Outer Sheath Components
    Gabriel Nussbaum, Shimon Ben-Adi, Tamar Genzler, Michael Sela, Graciela Rosen
  • Host Response and Inflammation
    Staphylococcus aureus Induces Microglial Inflammation via a Glycogen Synthase Kinase 3β-Regulated Pathway
    Yi-Lin Cheng, Chi-Yun Wang, Wei-Ching Huang, Cheng-Chieh Tsai, Chia-Ling Chen, Ching-Fen Shen, Chia-Yu Chi, Chiou-Feng Lin
  • Host Response and Inflammation
    Toll-Like Receptor 5-Dependent Regulation of Inflammation in Systemic Salmonella enterica Serovar Typhimurium Infection
    Bénédicte Fournier, Ifor R. Williams, Andrew T. Gewirtz, Andrew S. Neish
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Infection and Immunity: 77 (9)

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volume 77, issue 9
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