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Infection and Immunity
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Fungal and Parasitic Infections

A Regulator of Aspergillus fumigatus Extracellular Proteolytic Activity Is Dispensable for Virulence

Anna Bergmann, Thomas Hartmann, Timothy Cairns, Elaine M. Bignell, Sven Krappmann
Anna Bergmann
1Research Center for Infectious Diseases, Julius-Maximilians-University, Würzburg, Germany
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Thomas Hartmann
1Research Center for Infectious Diseases, Julius-Maximilians-University, Würzburg, Germany
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Timothy Cairns
2Department of Microbiology, Imperial College, London, United Kingdom
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Elaine M. Bignell
2Department of Microbiology, Imperial College, London, United Kingdom
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Sven Krappmann
1Research Center for Infectious Diseases, Julius-Maximilians-University, Würzburg, Germany
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  • For correspondence: sven.krappmann@uni-wuerzburg.de
DOI: 10.1128/IAI.00425-09
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ABSTRACT

Virulence of the fungal pathogen Aspergillus fumigatus is in part based on the saprophytic lifestyle that this mold has evolved. A crucial function for saprophytism resides in secreted proteases that allow assimilation of proteinaceous substrates. The impact of extracellular proteolytic activities on the pathogenesis of aspergillosis, however, remains controversial. In order to address this issue, characterization of a conserved regulatory factor, PrtT, that acts on expression of secreted proteases was pursued. Expression of PrtT appears to be regulated posttranscriptionally, and the existence of an mRNA leader sequence implies translational control via eIF2α kinase signaling. Phenotypic classification of a prtTΔ deletion mutant revealed that expression of several major extracellular proteases is PrtT dependent, resulting in the inability to utilize protein as a nutritional source. Certain genes encoding secreted proteases are not regulated by PrtT. Most strikingly, the deletant strain is not attenuated in virulence when tested in a leukopenic mouse model, which makes a strong case for reconsidering any impact of secreted proteases in pulmonary aspergillosis.

  • Copyright © 2009 American Society for Microbiology
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A Regulator of Aspergillus fumigatus Extracellular Proteolytic Activity Is Dispensable for Virulence
Anna Bergmann, Thomas Hartmann, Timothy Cairns, Elaine M. Bignell, Sven Krappmann
Infection and Immunity Aug 2009, 77 (9) 4041-4050; DOI: 10.1128/IAI.00425-09

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A Regulator of Aspergillus fumigatus Extracellular Proteolytic Activity Is Dispensable for Virulence
Anna Bergmann, Thomas Hartmann, Timothy Cairns, Elaine M. Bignell, Sven Krappmann
Infection and Immunity Aug 2009, 77 (9) 4041-4050; DOI: 10.1128/IAI.00425-09
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KEYWORDS

Aspergillus fumigatus
Fungal Proteins
Peptide Hydrolases
transcription factors

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