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Microbial Immunity and Vaccines

Salmonella enterica Serovar Typhimurium trxA Mutants Are Protective against Virulent Challenge and Induce Less Inflammation than the Live-Attenuated Vaccine Strain SL3261

S. E. Peters, G. K. Paterson, E. S. D. Bandularatne, H. C. Northen, S. Pleasance, C. Willers, J. Wang, A. K. Foote, F. Constantino-Casas, T. J. Scase, B. A. Blacklaws, C. E. Bryant, P. Mastroeni, I. G. Charles, D. J. Maskell
S. E. Peters
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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  • For correspondence: sep34@cam.ac.uk
G. K. Paterson
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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E. S. D. Bandularatne
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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H. C. Northen
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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S. Pleasance
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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C. Willers
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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J. Wang
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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A. K. Foote
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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F. Constantino-Casas
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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T. J. Scase
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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B. A. Blacklaws
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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C. E. Bryant
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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P. Mastroeni
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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I. G. Charles
2Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
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D. J. Maskell
1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
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DOI: 10.1128/IAI.00768-09
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Article Information

DOI 
https://doi.org/10.1128/IAI.00768-09
PubMed 
19884329

Published By 
American Society for Microbiology Journals
History 
  • Received July 9, 2009
  • Returned for modification August 18, 2009
  • Accepted October 11, 2009
  • Published online December 22, 2009.

Copyright & Usage 
Copyright © 2010 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (November 02, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. S. E. Peters1*,
  2. G. K. Paterson1,
  3. E. S. D. Bandularatne1†,
  4. H. C. Northen1,
  5. S. Pleasance1,
  6. C. Willers1,
  7. J. Wang1,
  8. A. K. Foote1‡,
  9. F. Constantino-Casas1,
  10. T. J. Scase1§,
  11. B. A. Blacklaws1,
  12. C. E. Bryant1,
  13. P. Mastroeni1,
  14. I. G. Charles2 and
  15. D. J. Maskell1
  1. 1Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
  2. 2Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
  • ↵* Corresponding author. Mailing address: Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom. Phone: 44 1223 337688. Fax: 44 1223 337671. E-mail: sep34{at}cam.ac.uk
  • ↵† Present address: Comparative Medicine Centre, National University of Singapore CeLS, 28 Medical Drive, #02-36 Singapore 117456.; ‡ Present address: Rossdale and Partners, Beaufort Cottage Laboratories, High Street, Newmarket, Suffolk CB8 8JS, United Kingdom.; § Present address: Bridge Pathology Ltd., Courtyard House, 26, Oakfield Road, Bristol BS8 2AT, United Kingdom.

  • Editor: A. J. Bäumler

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Salmonella enterica Serovar Typhimurium trxA Mutants Are Protective against Virulent Challenge and Induce Less Inflammation than the Live-Attenuated Vaccine Strain SL3261
S. E. Peters, G. K. Paterson, E. S. D. Bandularatne, H. C. Northen, S. Pleasance, C. Willers, J. Wang, A. K. Foote, F. Constantino-Casas, T. J. Scase, B. A. Blacklaws, C. E. Bryant, P. Mastroeni, I. G. Charles, D. J. Maskell
Infection and Immunity Dec 2009, 78 (1) 326-336; DOI: 10.1128/IAI.00768-09

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Salmonella enterica Serovar Typhimurium trxA Mutants Are Protective against Virulent Challenge and Induce Less Inflammation than the Live-Attenuated Vaccine Strain SL3261
S. E. Peters, G. K. Paterson, E. S. D. Bandularatne, H. C. Northen, S. Pleasance, C. Willers, J. Wang, A. K. Foote, F. Constantino-Casas, T. J. Scase, B. A. Blacklaws, C. E. Bryant, P. Mastroeni, I. G. Charles, D. J. Maskell
Infection and Immunity Dec 2009, 78 (1) 326-336; DOI: 10.1128/IAI.00768-09
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KEYWORDS

Bacterial Proteins
inflammation
Salmonella Infections, Animal
Salmonella Vaccines
Salmonella Typhimurium

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