Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Infection and Immunity
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About IAI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Spotlight

Articles of Significant Interest Selected from This Issue by the Editors

DOI: 10.1128/IAI.05835-11
  • Article
  • Info & Metrics
  • PDF
Loading

Neutrophils Take on a New Role in Antifungal Defense

Invasive aspergillosis, caused by the fungal pathogen Aspergillus fumigatus, is a major cause of mortality in patients undergoing hematopoietic and solid organ transplantation. Earlier studies established a role for the cytokine interleukin-17A (IL-17A) in A. fumigatus host defense. Werner and colleagues (p. 3966–3977) demonstrate that the immune cell required for clearing A. fumigatus from the lungs, the neutrophil, is an early cellular source of IL-17A. This work demonstrates that IL-17A production in neutrophils isolated from the lungs of infected mice and in peritoneal neutrophils from naïve mice stimulated with A. fumigatus is dependent on recognition of A. fumigatus by the beta-glucan receptor Dectin-1 and on Dectin-1-mediated IL-23 production. This work supports a new understanding for the role of neutrophils in invasive aspergillosis.

Pneumococcus-Infected Monocytes Induce a Mixed Th1/Th17 Response

Recent findings suggest that T helper (Th) cells contribute to acquired immunity to Streptococcus pneumoniae. Olliver and colleagues (p. 4210–4217) study bacterial and host factors involved in the induction of memory Th1 and Th17 responses in the human system using a coculture model of monocytes and CD4+ T cells. In this study, the authors show that purified pneumococcal peptidoglycan triggers both Th1 and Th17 cytokines but that the balance between the two immune effector arms depends on bacterial viability. These findings provide insight that may facilitate the design of pneumococcal vaccines and the development of novel immunomodulatory therapies.

  • Copyright © 2011, American Society for Microbiology. All Rights Reserved.
PreviousNext
Back to top
Download PDF
Citation Tools
Articles of Significant Interest Selected from This Issue by the Editors
Infection and Immunity Sep 2011, 79 (10) 3860; DOI: 10.1128/IAI.05835-11

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Infection and Immunity article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Articles of Significant Interest Selected from This Issue by the Editors
(Your Name) has forwarded a page to you from Infection and Immunity
(Your Name) thought you would be interested in this article in Infection and Immunity.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Articles of Significant Interest Selected from This Issue by the Editors
Infection and Immunity Sep 2011, 79 (10) 3860; DOI: 10.1128/IAI.05835-11
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • Neutrophils Take on a New Role in Antifungal Defense
    • Pneumococcus-Infected Monocytes Induce a Mixed Th1/Th17 Response
  • Info & Metrics
  • PDF

Related Articles

Cited By...

About

  • About IAI
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #IAIjournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0019-9567; Online ISSN: 1098-5522