Infection and Immunity: 81 (6)

June 1, 2013; Volume 81,Issue 6

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Articles of Significant Interest Selected from This Issue by the Editors

Molecular Pathogenesis

Molecular Pathogenesis
Staphylococcus aureus SasA Is Responsible for Binding to the Salivary Agglutinin gp340, Derived from Human Saliva
Kenji Kukita, Miki Kawada-Matsuo, Takahiko Oho, Mami Nagatomo, Yuichi Oogai, Masahito Hashimoto, Yasuo Suda, Takuo Tanaka, Hitoshi Komatsuzawa
Molecular Pathogenesis
The Fimbrial Protein FlfA from Gallibacterium anatis Is a Virulence Factor and Vaccine Candidate
Ragnhild J. Bager, Barbara Nesta, Susanne E. Pors, Marco Soriani, Laura Serino, John D. Boyce, Ben Adler, Anders M. Bojesen
Molecular Pathogenesis
Motility Is Crucial for the Infectious Life Cycle of Borrelia burgdorferi
Syed Z. Sultan, Akarsh Manne, Philip E. Stewart, Aaron Bestor, Patricia A. Rosa, Nyles W. Charon, M. A. Motaleb
Molecular Pathogenesis
Acquisition of the Sda1-Encoding Bacteriophage Does Not Enhance Virulence of the Serotype M1 Streptococcus pyogenes Strain SF370
Carola Venturini, Cheryl-lynn Y. Ong, Christine M. Gillen, Nouri L. Ben-Zakour, Peter G. Maamary, Victor Nizet, Scott A. Beatson, Mark J. Walker
Molecular Pathogenesis
The Streptococcal Cysteine Protease SpeB Is Not a Natural Immunoglobulin-Cleaving Enzyme
Helena Persson, Reine Vindebro, Ulrich von Pawel-Rammingen

Cellular Microbiology: Pathogen-host Cell Molecular Interactions

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Human Primary Intestinal Epithelial Cells as an Improved In Vitro Model for Cryptosporidium parvum Infection
Alejandro Castellanos-Gonzalez, Miguel M. Cabada, Joan Nichols, Guillermo Gomez, A. Clinton White
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Importance of PdpC, IglC, IglI, and IglG for Modulation of a Host Cell Death Pathway Induced by Francisella tularensis
Marie Lindgren, Kjell Eneslätt, Jeanette E. Bröms, Anders Sjöstedt
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Granzyme D Is a Novel Murine Mast Cell Protease That Is Highly Induced by Multiple Pathways of Mast Cell Activation
Elin Rönnberg, Gabriela Calounova, Bengt Guss, Anders Lundequist, Gunnar Pejler
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Enhanced, Sialoadhesin-Dependent Uptake of Guillain-Barré Syndrome-Associated Campylobacter jejuni Strains by Human Macrophages
Astrid P. Heikema, Roman I. Koning, Sharon Duarte dos Santos Rico, Hans Rempel, Bart C. Jacobs, Hubert P. Endtz, Willem J. B. van Wamel, Janneke N. Samsom
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Targeting of the Small GTPase Rab6A′ by the Legionella pneumophila Effector LidA
Yang Chen, Matthias P. Machner
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Key Role for the Alternative Sigma Factor, SigH, in the Intracellular Life of Mycobacterium avium subsp. paratuberculosis during Macrophage Stress
Pallab Ghosh, Chia-wei Wu, Adel M. Talaat

Bacterial Infections

Bacterial Infections
Absence of Platelet Endothelial Cell Adhesion Molecule 1, PECAM-1/CD31, In Vivo Increases Resistance to Salmonella enterica Serovar Typhimurium in Mice
Michael D. Lovelace, May Lin Yap, Jana Yip, William Muller, Odilia Wijburg, Denise E. Jackson
Bacterial Infections
Dipterinyl Calcium Pentahydrate Inhibits Intracellular Mycobacterial Growth in Human Monocytes via the C-C Chemokine MIP-1β and Nitric Oxide
Isaac G. Sakala, Christopher S. Eickhoff, Azra Blazevic, Phillip Moheno, Richard F. Silver, Daniel F. Hoft
Bacterial Infections
RegA, the Regulator of the Two-Component System RegB/RegA of Brucella suis, Is a Controller of Both Oxidative Respiration and Denitrification Required for Chronic Infection in Mice
Elias Abdou, Amélie Deredjian, María Pilar Jiménez de Bagüés, Stephan Köhler, Véronique Jubier-Maurin
Bacterial Infections
Identification of a Peptide-Based Neutralizer That Potently Inhibits Both Shiga Toxins 1 and 2 by Targeting Specific Receptor-Binding Regions
Kazue Tsutsuki, Miho Watanabe-Takahashi, Yasuaki Takenaka, Eiji Kita, Kiyotaka Nishikawa
Bacterial Infections
Heterozygosity at the A625C Polymorphic Site of the MyD88 Gene Is Associated with Mycobacterium bovis Infection in Cattle
Rosanna Capparelli, Francesco De Chiara, Nunzia Nocerino, Chiara Medaglia, Rosa Di Costanzo, Luigi Ramunno, Federico Capuano, Francesco Casalinuovo, Antonio Di Matteo, Domenico Iannelli

Host Response and Inflammation

Host Response and Inflammation
Prolonged NF-κB Activation by a Macrophage Inhibitory Cytokine 1-Linked Signal in Enteropathogenic Escherichia coli-Infected Epithelial Cells
Hye Jin Choi, Juil Kim, Kee Hun Do, Seong-Hwan Park, Yuseok Moon
Host Response and Inflammation
Plasmodium coatneyi in Rhesus Macaques Replicates the Multisystemic Dysfunction of Severe Malaria in Humans
Alberto Moreno, Monica Cabrera-Mora, AnaPatricia Garcia, Jack Orkin, Elizabeth Strobert, John W. Barnwell, Mary R. Galinski
Host Response and Inflammation
Parasitic Nematode-Induced Modulation of Body Weight and Associated Metabolic Dysfunction in Mouse Models of Obesity
Zhonghan Yang, Viktoriya Grinchuk, Allen Smith, Bolin Qin, Jennifer A. Bohl, Rex Sun, Luigi Notari, Zhongyan Zhang, Hiromi Sesaki, Joseph F. Urban, Terez Shea-Donohue, Aiping Zhao
Host Response and Inflammation
Exacerbated Type II Interferon Response Drives Hypervirulence and Toxic Shock by an Emergent Epidemic Strain of Streptococcus suis
Claude Lachance, Marcelo Gottschalk, Pehuén P. Gerber, Paul Lemire, Jianguo Xu, Mariela Segura
Host Response and Inflammation
Brucella abortus Invasion of Synoviocytes Inhibits Apoptosis and Induces Bone Resorption through RANKL Expression
Romina Scian, Paula Barrionuevo, Ana María Rodriguez, Paula Constanza Arriola Benitez, Clara García Samartino, Carlos Alberto Fossati, Guillermo Hernán Giambartolomei, María Victoria Delpino
Host Response and Inflammation
Differing Effects of Interleukin-10 on Cutaneous and Pulmonary Francisella tularensis Live Vaccine Strain Infection
Dennis W. Metzger, Sharon L. Salmon, Girish Kirimanjeswara
Host Response and Inflammation
Flagellar Motility Is a Key Determinant of the Magnitude of the Inflammasome Response to Pseudomonas aeruginosa
Yash R. Patankar, Rustin R. Lovewell, Matthew E. Poynter, Jeevan Jyot, Barbara I. Kazmierczak, Brent Berwin
Host Response and Inflammation
Clearance of Staphylococcus aureus Nasal Carriage Is T Cell Dependent and Mediated through Interleukin-17A Expression and Neutrophil Influx
Nathan K. Archer, Janette M. Harro, Mark E. Shirtliff
Host Response and Inflammation
Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15
Kirk D. C. Jensen, Kenneth Hu, Ryan J. Whitmarsh, Musa A. Hassan, Lindsay Julien, Diana Lu, Lieping Chen, Christopher A. Hunter, Jeroen P. J. Saeij
Host Response and Inflammation
CD137 Expressed on Neutrophils Plays Dual Roles in Antibacterial Responses against Gram-Positive and Gram-Negative Bacterial Infections
Quang-Tam Nguyen, Thu-Ha T. Nguyen, Seong-A. Ju, Yea-Sol Lee, Seung Hyun Han, Sang-Chul Lee, Byoung S. Kwon, Rina Yu, Gyu Yeol Kim, Byung Ju Lee, Byung-Sam Kim
Host Response and Inflammation
Toll-Like Receptor 4/Stem Cell Antigen 1 Signaling Promotes Hematopoietic Precursor Cell Commitment to Granulocyte Development during the Granulopoietic Response to Escherichia coli Bacteremia
Xin Shi, Robert W. Siggins, William L. Stanford, John N. Melvan, Marc D. Basson, Ping Zhang
Host Response and Inflammation
Increased Resistance to Staphylococcus aureus Endophthalmitis in BALB/c Mice: Fas Ligand Is Required for Resolution of Inflammation but Not for Bacterial Clearance
Norito Sugi, Emily A. Whiston, Bruce R. Ksander, Meredith S. Gregory
Host Response and Inflammation
High Dietary Salt Intake Exacerbates Helicobacter pylori-Induced Gastric Carcinogenesis
Jennifer A. Gaddy, Jana N. Radin, John T. Loh, Feng Zhang, M. Kay Washington, Richard M. Peek, Holly M. Scott Algood, Timothy L. Cover

Fungal and Parasitic Infections

Fungal and Parasitic Infections
CD40 Induces Anti-Toxoplasma gondii Activity in Nonhematopoietic Cells Dependent on Autophagy Proteins
Jennifer Van Grol, Luis Muniz-Feliciano, Jose-Andres C. Portillo, Vera L. Bonilha, Carlos S. Subauste
Fungal and Parasitic Infections
Hookworm Excretory/Secretory Products Induce Interleukin-4 (IL-4)⁺ IL-10⁺ CD4⁺ T Cell Responses and Suppress Pathology in a Mouse Model of Colitis
Ivana Ferreira, Danielle Smyth, Soraya Gaze, Ammar Aziz, Paul Giacomin, Nathalie Ruyssers, David Artis, Thewarach Laha, Severine Navarro, Alex Loukas, Henry J. McSorley
Fungal and Parasitic Infections
Localization of Phosphatidylinositol 4,5-Bisphosphate to Lipid Rafts and Uroids in the Human Protozoan Parasite Entamoeba histolytica
Amrita B. Koushik, Rhonda R. Powell, Lesly A. Temesvari
Fungal and Parasitic Infections
Candida albicans-Staphylococcus aureus Polymicrobial Peritonitis Modulates Host Innate Immunity
Brian M. Peters, Mairi C. Noverr
Fungal and Parasitic Infections
Characterization of the Pneumocystis carinii Histone Acetyltransferase Chaperone Proteins PcAsf1 and PcVps75
Jakrapun Pupaibool, Theodore J. Kottom, Kelly Bouchonville, Andrew H. Limper

Microbial Immunity and Vaccines

Microbial Immunity and Vaccines
Combinations of Monoclonal Antibodies to Anthrax Toxin Manifest New Properties in Neutralization Assays
Mary Ann Pohl, Johanna Rivera, Antonio Nakouzi, Siu-Kei Chow, Arturo Casadevall
Microbial Immunity and Vaccines
ZnuD, a Potential Candidate for a Simple and Universal Neisseria meningitidis Vaccine
Kerstin Hubert, Nathalie Devos, Ines Mordhorst, Christine Tans, Guy Baudoux, Christiane Feron, Karine Goraj, Jan Tommassen, Ulrich Vogel, Jan T. Poolman, Vincent Weynants
Microbial Immunity and Vaccines
Anti-Pfs25 Human Plasma Reduces Transmission of Plasmodium falciparum Isolates That Have Diverse Genetic Backgrounds
Dari F. Da, Saurabh Dixit, Jetsumon Sattabonkot, Jianbing Mu, Luc Abate, Bhanumati Ramineni, Jean Bosco Ouedraogo, Nicholas J. MacDonald, Michael P. Fay, Xin-zhuan Su, Anna Cohuet, Yimin Wu
Microbial Immunity and Vaccines
Postexposure Subunit Vaccination against Chronic Enteric Mycobacterial Infection in a Natural Host
Wiebren Santema, Victor Rutten, Ruud Segers, Jacqueline Poot, Selma Hensen, Hans Heesterbeek, Ad Koets
Microbial Immunity and Vaccines
Infection with Francisella tularensis LVS clpB Leads to an Altered yet Protective Immune Response
Lydia M. Barrigan, Shraddha Tuladhar, Jason C. Brunton, Matthew D. Woolard, Ching-ju Chen, Divey Saini, Richard Frothingham, Gregory D. Sempowski, Thomas H. Kawula, Jeffrey A. Frelinger
Microbial Immunity and Vaccines
Formalin-Inactivated Coxiella burnetii Phase I Vaccine-Induced Protection Depends on B Cells To Produce Protective IgM and IgG
Guoquan Zhang, Ying Peng, Laura Schoenlaub, Alexandra Elliott, William Mitchell, Yan Zhang
Microbial Immunity and Vaccines
Intranasal Prophylaxis with CpG Oligodeoxynucleotide Can Protect against Yersinia pestis Infection
Anthony J. Hickey, Jr-Shiuan Lin, Lawrence W. Kummer, Frank M. Szaba, Debra K. Duso, Michael Tighe, Michelle A. Parent, Stephen T. Smiley
Microbial Immunity and Vaccines
Toll-Like Receptor 5-Dependent Immunogenicity and Protective Efficacy of a Recombinant Fusion Protein Vaccine Containing the Nontoxic Domains of Clostridium difficile Toxins A and B and Salmonella enterica Serovar Typhimurium Flagellin in a Mouse Model of Clostridium difficile Disease
Chandrabali Ghose, Janneke M. Verhagen, Xinhua Chen, Jian Yu, Yaoxing Huang, Olivia Chenesseau, Ciarán P. Kelly, David D. Ho
Microbial Immunity and Vaccines
Molecular Characterization of the Carboxypeptidase B1 of Anopheles stephensi and Its Evaluation as a Target for Transmission-Blocking Vaccines
Abbasali Raz, Navid Dinparast Djadid, Sedigheh Zakeri

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Table of Contents

Spotlight

Molecular Pathogenesis

Cellular Microbiology: Pathogen-host Cell Molecular Interactions

Bacterial Infections

Host Response and Inflammation

Fungal and Parasitic Infections

Microbial Immunity and Vaccines

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