Infection and Immunity: 81 (8)

August 1, 2013; Volume 81,Issue 8

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Articles of Significant Interest Selected from This Issue by the Editors

Molecular Pathogenesis

Molecular Pathogenesis
Redox Balance via Lactate Dehydrogenase Is Important for Multiple Stress Resistance and Virulence in Enterococcus faecalis
Nosheen Fatima Rana, Nicolas Sauvageot, Jean-Marie Laplace, YinYin Bao, Ingolf Nes, Alain Rincé, Brunella Posteraro, Maurizio Sanguinetti, Axel Hartke
Molecular Pathogenesis
Manganese and Zinc Regulate Virulence Determinants in Borrelia burgdorferi
Bryan Troxell, Meiping Ye, Youyun Yang, Sebastian E. Carrasco, Yongliang Lou, X. Frank Yang
Molecular Pathogenesis
Binding of Pk-Trisaccharide Analogs of Globotriaosylceramide to Shiga Toxin Variants
Hailemichael O. Yosief, Suri S. Iyer, Alison A. Weiss
Molecular Pathogenesis
Functional Characterization of Burkholderia pseudomallei Trimeric Autotransporters
Cristine G. Campos, Matthew S. Byrd, Peggy A. Cotter
Molecular Pathogenesis
The Francisella tularensis migR, trmE, and cphA Genes Contribute to F. tularensis Pathogenicity Island Gene Regulation and Intracellular Growth by Modulation of the Stress Alarmone ppGpp
Matthew Faron, Joshua R. Fletcher, Jed A. Rasmussen, Matthew E. Long, Lee-Ann H. Allen, Bradley D. Jones
Molecular Pathogenesis
Escherichia coli Heat-Stable Toxin b Impairs Intestinal Epithelial Barrier Function by Altering Tight Junction Proteins
Clément Ngendahayo Mukiza, J. Daniel Dubreuil
Molecular Pathogenesis
FeoB-Mediated Uptake of Iron by Francisella tularensis
Cindy A. Thomas-Charles, Huaixin Zheng, Lance E. Palmer, Patricio Mena, David G. Thanassi, Martha B. Furie
Molecular Pathogenesis
The Fur-Iron Complex Modulates Expression of the Quorum-Sensing Master Regulator, SmcR, To Control Expression of Virulence Factors in Vibrio vulnificus
In Hwang Kim, Yancheng Wen, Jee-Soo Son, Kyu-Ho Lee, Kun-Soo Kim
Molecular Pathogenesis
The RNA Chaperone Hfq Promotes Fitness of Actinobacillus pleuropneumoniae during Porcine Pleuropneumonia
Sargurunathan Subashchandrabose, Rhiannon M. Leveque, Roy N. Kirkwood, Matti Kiupel, Martha H. Mulks
Molecular Pathogenesis
Contributions of Environmental Signals and Conserved Residues to the Functions of Carbon Storage Regulator A of Borrelia burgdorferi
S. L. Rajasekhar Karna, Rajesh G. Prabhu, Ying-Han Lin, Christine L. Miller, J. Seshu
Molecular Pathogenesis
Role of Klebsiella pneumoniae Type 1 and Type 3 Fimbriae in Colonizing Silicone Tubes Implanted into the Bladders of Mice as a Model of Catheter-Associated Urinary Tract Infections
Caitlin N. Murphy, Martin S. Mortensen, Karen A. Krogfelt, Steven Clegg

Cellular Microbiology: Pathogen-host Cell Molecular Interactions

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Upregulation of the Host SLC11A1 Gene by Clostridium difficile Toxin B Facilitates Glucosylation of Rho GTPases and Enhances Toxin Lethality
Yanan Feng, Stanley N. Cohen
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Human Endothelial Cells Internalize Candida parapsilosis via N-WASP-Mediated Endocytosis
Tatsushi Shintaku, Kyle A. Glass, Matthew P. Hirakawa, Sarah J. Longley, Richard J. Bennett, Joseph M. Bliss, Sunil K. Shaw
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Divergent Mechanisms of Interaction of Helicobacter pylori and Campylobacter jejuni with Mucus and Mucins
Julie Ann Naughton, Karina Mariño, Brendan Dolan, Colm Reid, Ronan Gough, Mary E. Gallagher, Michelle Kilcoyne, Jared Q. Gerlach, Lokesh Joshi, Pauline Rudd, Stephen Carrington, Billy Bourke, Marguerite Clyne
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Divergent Immune Responses to Mycobacterium avium subsp. paratuberculosis Infection Correlate with Kinome Responses at the Site of Intestinal Infection
Pekka Määttänen, Brett Trost, Erin Scruten, Andrew Potter, Anthony Kusalik, Philip Griebel, Scott Napper
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Phosphatidylinositol 4,5-Bisphosphate Is a Novel Coactivator of the Pseudomonas aeruginosa Cytotoxin ExoU
Gregory H. Tyson, Alan R. Hauser
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Inhibition of Water Absorption and Selective Damage to Human Colonic Mucosa Are Induced by Subtilase Cytotoxin Produced by Escherichia coli O113:H21
Elizabeth Gerhardt, Mariana Masso, Adrienne W. Paton, James C. Paton, Elsa Zotta, Cristina Ibarra
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Perforin-2 Restricts Growth of Chlamydia trachomatis in Macrophages
K. A. Fields, R. McCormack, L. R. de Armas, E. R. Podack

Bacterial Infections

Bacterial Infections
Pseudomonas aeruginosa Uses Multiple Pathways To Acquire Iron during Chronic Infection in Cystic Fibrosis Lungs
Anna F. Konings, Lois W. Martin, Katrina J. Sharples, Louise F. Roddam, Roger Latham, David W. Reid, Iain L. Lamont
Bacterial Infections
Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria
Louise D. Christensen, Maria van Gennip, Morten T. Rybtke, Hong Wu, Wen-Chi Chiang, Morten Alhede, Niels Høiby, Thomas E. Nielsen, Michael Givskov, Tim Tolker-Nielsen
Bacterial Infections
Fitness, Stress Resistance, and Extraintestinal Virulence in Escherichia coli
Alexandre Bleibtreu, Pierre-Alexis Gros, Cédric Laouénan, Olivier Clermont, Hervé Le Nagard, Bertrand Picard, Olivier Tenaillon, Erick Denamur
Bacterial Infections
Leptospiral Outer Membrane Protein LipL41 Is Not Essential for Acute Leptospirosis but Requires a Small Chaperone Protein, Lep, for Stable Expression
Amy M. King, Thanatchaporn Bartpho, Rasana W. Sermswan, Dieter M. Bulach, Azad Eshghi, Mathieu Picardeau, Ben Adler, Gerald L. Murray
Bacterial Infections
Protective Efficacy Induced by Recombinant Clostridium difficile Toxin Fragments
Rosanna Leuzzi, Janice Spencer, Anthony Buckley, Cecilia Brettoni, Manuele Martinelli, Lorenza Tulli, Sara Marchi, Enrico Luzzi, June Irvine, Denise Candlish, Daniele Veggi, Werner Pansegrau, Luigi Fiaschi, Silvana Savino, Erwin Swennen, Osman Cakici, Ernesto Oviedo-Orta, Monica Giraldi, Barbara Baudner, Nunzia D'Urzo, Domenico Maione, Marco Soriani, Rino Rappuoli, Mariagrazia Pizza, Gillian R. Douce, Maria Scarselli
Open Access

Bacterial Infections
Borrelia hermsii Acquisition Order in Superinfected Ticks Determines Transmission Efficiency
Paul F. Policastro, Sandra J. Raffel, Tom G. Schwan
Bacterial Infections
Differential Virulence and Disease Progression following Mycobacterium tuberculosis Complex Infection of the Common Marmoset (Callithrix jacchus)
Laura E. Via, Danielle M. Weiner, Daniel Schimel, Philana Ling Lin, Emmanuel Dayao, Sarah L. Tankersley, Ying Cai, M. Teresa Coleman, Jaime Tomko, Praveen Paripati, Marlene Orandle, Robin J. Kastenmayer, Michael Tartakovsky, Alexander Rosenthal, Damien Portevin, Seok Yong Eum, Saher Lahouar, Sebastien Gagneux, Douglas B. Young, JoAnne L. Flynn, Clifton E. Barry
Bacterial Infections
Gallbladder Epithelium as a Niche for Chronic Salmonella Carriage
Geoffrey Gonzalez-Escobedo, John S. Gunn
Bacterial Infections
Persistence, Immune Response, and Antigenic Variation of Mycoplasma genitalium in an Experimentally Infected Pig-Tailed Macaque (Macaca nemestrina)
Gwendolyn E. Wood, Stefanie L. Iverson-Cabral, Dorothy L. Patton, Peter K. Cummings, Yvonne T. Cosgrove Sweeney, Patricia A. Totten
Open Access

Bacterial Infections
Borrelia burgdorferi Linear Plasmid 28-3 Confers a Selective Advantage in an Experimental Mouse-Tick Infection Model
Daniel P. Dulebohn, Aaron Bestor, Patricia A. Rosa

Host Response and Inflammation

Host Response and Inflammation
Shiga Toxin 2 Reduces Complement Inhibitor CD59 Expression on Human Renal Tubular Epithelial and Glomerular Endothelial Cells
Silvia Ehrlenbach, Alejandra Rosales, Wilfried Posch, Doris Wilflingseder, Martin Hermann, Jens Brockmeyer, Helge Karch, Simon C. Satchell, Reinhard Würzner, Dorothea Orth-Höller
Host Response and Inflammation
Cdc42 Promotes Host Defenses against Fatal Infection
Keunwook Lee, Kelli L. Boyd, Diptiben V. Parekh, Thomas E. Kehl-Fie, H. Scott Baldwin, Cord Brakebusch, Eric P. Skaar, Mark Boothby, Roy Zent
Host Response and Inflammation
Contribution of Interleukin-12 p35 (IL-12p35) and IL-12p40 to Protective Immunity and Pathology in Mice Infected with Chlamydia muridarum
Lili Chen, Lei Lei, Zhou Zhou, Jie He, Sha Xu, Chunxue Lu, Jianlin Chen, Zhangsheng Yang, Gangqiu Wu, I-Tien Yeh, Guangming Zhong, Yimou Wu
Host Response and Inflammation
Haemophilus ducreyi Infection Induces Activation of the NLRP3 Inflammasome in Nonpolarized but Not in Polarized Human Macrophages
Wei Li, Barry P. Katz, Margaret E. Bauer, Stanley M. Spinola
Host Response and Inflammation
Enhanced Susceptibility to Urinary Tract Infection in the Spinal Cord-Injured Host with Neurogenic Bladder
Zarine R. Balsara, Sherry S. Ross, Paul C. Dolber, John S. Wiener, Yuping Tang, Patrick C. Seed
Host Response and Inflammation
Agglutinating Secretory IgA Preserves Intestinal Epithelial Cell Integrity during Apical Infection by Shigella flexneri
Amandine Mathias, Stéphanie Longet, Blaise Corthésy
Host Response and Inflammation
Gene Dosage-Dependent Negative Regulatory Role of β-Arrestin-2 in Polymicrobial Infection-Induced Inflammation
Deepika Sharma, Ankit Malik, Eunhee Lee, Robert A. Britton, Narayanan Parameswaran

Fungal and Parasitic Infections

Fungal and Parasitic Infections
Protective Role of Murine β-Defensins 3 and 4 and Cathelin-Related Antimicrobial Peptide in Fusarium solani Keratitis
Satya Sree N. Kolar, Hasna Baidouri, Samuel Hanlon, Alison M. McDermott
Fungal and Parasitic Infections
Malaria Modifies Neonatal and Early-Life Toll-Like Receptor Cytokine Responses
Komi Gbédandé, Stefania Varani, Samad Ibitokou, Parfait Houngbegnon, Sophie Borgella, Odilon Nouatin, Sem Ezinmegnon, Adicatou-laï Adeothy, Gilles Cottrell, Achille Massougbodji, Kabirou Moutairou, Marita Troye-Blomberg, Philippe Deloron, Nadine Fievet, Adrian J. F. Luty