Infection and Immunity: 82 (6)

June 1, 2014; Volume 82,Issue 6

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Articles of Significant Interest Selected from This Issue by the Editors

Commentary

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Commentary
Lipid A Is More than Acyl Chains
Michael A. Apicella

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Impact of Staphylococcus aureus on Pathogenesis in Polymicrobial Infections
Nisha Nair, Raja Biswas, Friedrich Götz, Lalitha Biswas

Molecular Pathogenesis

Molecular Pathogenesis
The Iron-Sensing Fur Regulator Controls Expression Timing and Levels of Salmonella Pathogenicity Island 2 Genes in the Course of Environmental Acidification
Eunna Choi, Hyunkeun Kim, Hwiseop Lee, Daesil Nam, Jeongjoon Choi, Dongwoo Shin
Molecular Pathogenesis
Phenotypic Screening of a Targeted Mutant Library Reveals Campylobacter jejuni Defenses against Oxidative Stress
Annika Flint, Yi-Qian Sun, James Butcher, Martin Stahl, Hongsheng Huang, Alain Stintzi
Molecular Pathogenesis
RTX Toxin Plays a Key Role in Kingella kingae Virulence in an Infant Rat Model
Dennis W. Chang, Yoav A. Nudell, Jenny Lau, Eleonora Zakharian, Nataliya V. Balashova
Molecular Pathogenesis
Modulation of Vacuolar pH Is Required for Replication of Edwardsiella ictaluri in Channel Catfish Macrophages
Wes A. Baumgartner, Lidiya Dubytska, Matthew L. Rogge, Peter J. Mottram, Ronald L. Thune
Molecular Pathogenesis
DrsG from Streptococcus dysgalactiae subsp. equisimilis Inhibits the Antimicrobial Peptide LL-37
Danielle Smyth, Ainslie Cameron, Mark R. Davies, Celia McNeilly, Louise Hafner, Kadaba S. Sriprakash, David J. McMillan
Molecular Pathogenesis
Clostridium difficile Extracytoplasmic Function σ Factor σ^V Regulates Lysozyme Resistance and Is Necessary for Pathogenesis in the Hamster Model of Infection
Theresa D. Ho, Kyle B. Williams, Yan Chen, Richard F. Helm, David L. Popham, Craig D. Ellermeier
Molecular Pathogenesis
Aerobactin Mediates Virulence and Accounts for Increased Siderophore Production under Iron-Limiting Conditions by Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae
Thomas A. Russo, Ruth Olson, Ulrike MacDonald, Daniel Metzger, Lauren M. Maltese, Eric J. Drake, Andrew M. Gulick
Molecular Pathogenesis
A Fine-Tuned Interaction between Trimeric Autotransporter Haemophilus Surface Fibrils and Vitronectin Leads to Serum Resistance and Adherence to Respiratory Epithelial Cells
Birendra Singh, Yu-Ching Su, Tamim Al-Jubair, Oindrilla Mukherjee, Teresia Hallström, Matthias Mörgelin, Anna M. Blom, Kristian Riesbeck
Molecular Pathogenesis
Role of Capsule and Suilysin in Mucosal Infection of Complement-Deficient Mice with Streptococcus suis
Maren Seitz, Andreas Beineke, Alena Singpiel, Jörg Willenborg, Pavel Dutow, Ralph Goethe, Peter Valentin-Weigand, Andreas Klos, Christoph G. Baums
Molecular Pathogenesis
Deletion of Braun Lipoprotein and Plasminogen-Activating Protease-Encoding Genes Attenuates Yersinia pestis in Mouse Models of Bubonic and Pneumonic Plague
Christina J. van Lier, Jian Sha, Michelle L. Kirtley, Anthony Cao, Bethany L. Tiner, Tatiana E. Erova, Yingzi Cong, Elena V. Kozlova, Vsevolod L. Popov, Wallace B. Baze, Ashok K. Chopra
Molecular Pathogenesis
A Putative Regulatory Genetic Locus Modulates Virulence in the Pathogen Leptospira interrogans
Azad Eshghi, Jérôme Becam, Ambroise Lambert, Odile Sismeiro, Marie-Agnès Dillies, Bernd Jagla, Elsio A. Wunder, Albert I. Ko, Jean-Yves Coppee, Cyrille Goarant, Mathieu Picardeau

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Sialic Acid Residues Are Essential for Cell Lysis Mediated by Leukotoxin from Aggregatibacter actinomycetemcomitans
Peter Svenssen Munksgaard, Marianne Skals, Jesper Reinholdt, Knud Poulsen, Maria Risager Jensen, Chuanxu Yang, Jens Leipziger, Thomas Vorup-Jensen, Helle A. Praetorius
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Coxiella burnetii Type IV Secretion-Dependent Recruitment of Macrophage Autophagosomes
Caylin G. Winchell, Joseph G. Graham, Richard C. Kurten, Daniel E. Voth
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
EspC Promotes Epithelial Cell Detachment by Enteropathogenic Escherichia coli via Sequential Cleavages of a Cytoskeletal Protein and then Focal Adhesion Proteins
Fernando Navarro-Garcia, Antonio Serapio-Palacios, Jorge E. Vidal, M. Isabel Salazar, Gabriela Tapia-Pastrana
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Identification of a Group B Streptococcal Fibronectin Binding Protein, SfbA, That Contributes to Invasion of Brain Endothelium and Development of Meningitis
Rong Mu, Brandon J. Kim, Czarinah Paco, Yvette Del Rosario, Harry S. Courtney, Kelly S. Doran
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Identification of an Outer Membrane Lipoprotein Involved in Nasopharyngeal Colonization by Moraxella catarrhalis in an Animal Model
Wei Wang, Stephanie N. Joslin, Christine Pybus, Amanda S. Evans, Flora Lichaa, Chad A. Brautigam, Eric J. Hansen
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Type III Secretion Needle Proteins Induce Cell Signaling and Cytokine Secretion via Toll-Like Receptors
Danielle L. Jessen, Patrick Osei-Owusu, Melody Toosky, William Roughead, David S. Bradley, Matthew L. Nilles
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Citrullination and Proteolytic Processing of Chemokines by Porphyromonas gingivalis
Eva A. V. Moelants, Gitte Loozen, Anneleen Mortier, Erik Martens, Ghislain Opdenakker, Danuta Mizgalska, Borys Szmigielski, Jan Potempa, Jo Van Damme, Wim Teughels, Paul Proost
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
GRA25 Is a Novel Virulence Factor of Toxoplasma gondii and Influences the Host Immune Response
Anjali J. Shastri, Nicole D. Marino, Magdalena Franco, Melissa B. Lodoen, John C. Boothroyd
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Interaction of Prevotella intermedia Strain 17 Leucine-Rich Repeat Domain Protein AdpF with Eukaryotic Cells Promotes Bacterial Internalization
Dipanwita Sengupta, Dae-Joong Kang, Cecilia Anaya-Bergman, Tiana Wyant, Arnab K. Ghosh, Hiroshi Miyazaki, Janina P. Lewis
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Salmonella enterica Invasion of Polarized Epithelial Cells Is a Highly Cooperative Effort
Martin Lorkowski, Alfonso Felipe-López, Claudia A. Danzer, Nicole Hansmeier, Michael Hensel

Bacterial Infections

Bacterial Infections
Establishment of Three Francisella Infections in Zebrafish Embryos at Different Temperatures
Espen Brudal, Lilia S. Ulanova, Elisabeth O. Lampe, Anne-Lise Rishovd, Gareth Griffiths, Hanne C. Winther-Larsen
Bacterial Infections
Clostridium perfringens Type A Enterotoxin Damages the Rabbit Colon
Jorge P. Garcia, Jihong Li, Archana Shrestha, John C. Freedman, Juliann Beingesser, Bruce A. McClane, Francisco A. Uzal
Bacterial Infections
BEC, a Novel Enterotoxin of Clostridium perfringens Found in Human Clinical Isolates from Acute Gastroenteritis Outbreaks
Shinya Yonogi, Shigeaki Matsuda, Takao Kawai, Tomoko Yoda, Tetsuya Harada, Yuko Kumeda, Kazuyoshi Gotoh, Hirotaka Hiyoshi, Shota Nakamura, Toshio Kodama, Tetsuya Iida
Bacterial Infections
Early Changes by ¹⁸Fluorodeoxyglucose Positron Emission Tomography Coregistered with Computed Tomography Predict Outcome after Mycobacterium tuberculosis Infection in Cynomolgus Macaques
M. Teresa Coleman, Pauline Maiello, Jaime Tomko, Lonnie James Frye, Daniel Fillmore, Christopher Janssen, Edwin Klein, Philana Ling Lin
Bacterial Infections
IsdC from Staphylococcus lugdunensis Induces Biofilm Formation under Low-Iron Growth Conditions
Antonino Missineo, Antonella Di Poto, Joan A. Geoghegan, Simonetta Rindi, Simon Heilbronner, Valentina Gianotti, Carla Renata Arciola, Timothy J. Foster, Pietro Speziale, Giampiero Pietrocola
Bacterial Infections
Phase Variation Mediates Reductions in Expression of Surface Proteins during Persistent Meningococcal Carriage
Mohamed Alamro, Fadil A. Bidmos, Hannah Chan, Neil J. Oldfield, Emma Newton, Xilian Bai, Jack Aidley, Rory Care, Claire Mattick, David P. J. Turner, Keith R. Neal, Dlawer A. A. Ala'Aldeen, Ian Feavers, Ray Borrow, Christopher D. Bayliss
Bacterial Infections
Fibronectin-Binding Protein of Borrelia hermsii Expressed in the Blood of Mice with Relapsing Fever
Eric R. G. Lewis, Renee A. Marcsisin, Shelley A. Campeau Miller, Fong Hue, April Phillips, David P. AuCoin, Alan G. Barbour
Bacterial Infections
Vitamin D Deficiency Reduces the Immune Response, Phagocytosis Rate, and Intracellular Killing Rate of Microglial Cells
Marija Djukic, Marie Luise Onken, Sandra Schütze, Sandra Redlich, Alexander Götz, Uwe-Karsten Hanisch, Thomas Bertsch, Sandra Ribes, Andrea Hanenberg, Simon Schneider, Cornelius Bollheimer, Cornel Sieber, Roland Nau
Bacterial Infections
Two Novel Functions of Hyaluronidase from Streptococcus agalactiae Are Enhanced Intracellular Survival and Inhibition of Proinflammatory Cytokine Expression
Zhaofei Wang, Changming Guo, Yannan Xu, Guangjin Liu, Chengping Lu, Yongjie Liu
Bacterial Infections
Role of Class 1 Serine Protease Autotransporter in the Pathogenesis of Citrobacter rodentium Colitis
Vidhya Vijayakumar, Araceli Santiago, Rachel Smith, Mark Smith, Roy M. Robins-Browne, James P. Nataro, Fernando Ruiz-Perez

Host Response and Inflammation

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Host Response and Inflammation
Phosphoethanolamine Decoration of Neisseria gonorrhoeae Lipid A Plays a Dual Immunostimulatory and Protective Role during Experimental Genital Tract Infection
Mathanraj Packiam, Roshan D. Yedery, Afrin A. Begum, Russell W. Carlson, Jhuma Ganguly, Gregory D. Sempowski, Melissa S. Ventevogel, William M. Shafer, Ann E. Jerse
Host Response and Inflammation
Hydrophobic Determinants of α-Defensin Bactericidal Activity
Kenneth P. Tai, Valerie V. Le, Michael E. Selsted, André J. Ouellette
Host Response and Inflammation
Induction of Bacterial Antigen-Specific Colitis by a Simplified Human Microbiota Consortium in Gnotobiotic Interleukin-10^−/− Mice
Chang Soo Eun, Yoshiyuki Mishima, Steffen Wohlgemuth, Bo Liu, Maureen Bower, Ian M. Carroll, R. Balfour Sartor
Host Response and Inflammation
Salmonella enterica Serovar Typhi Impairs CD4 T Cell Responses by Reducing Antigen Availability
Shaikh M. Atif, Sebastian E. Winter, Maria G. Winter, Stephen J. McSorley, Andreas J. Bäumler
Host Response and Inflammation
Type I Interferon Signaling Regulates Activation of the Absent in Melanoma 2 Inflammasome during Streptococcus pneumoniae Infection
Rendong Fang, Hideki Hara, Shunsuke Sakai, Eduardo Hernandez-Cuellar, Masao Mitsuyama, Ikuo Kawamura, Kohsuke Tsuchiya
Host Response and Inflammation
Interleukin 17A Promotes Pneumococcal Clearance by Recruiting Neutrophils and Inducing Apoptosis through a p38 Mitogen-Activated Protein Kinase-Dependent Mechanism in Acute Otitis Media
Wei Wang, Aie Zhou, Xuemei Zhang, Yun Xiang, Yifei Huang, Lei Wang, Shuai Zhang, Yusi Liu, Yibing Yin, Yujuan He
Host Response and Inflammation
Borrelia burgdorferi RNA Induces Type I and III Interferons via Toll-Like Receptor 7 and Contributes to Production of NF-κB-Dependent Cytokines
Andrea C. Love, Ira Schwartz, Mary M. Petzke
Host Response and Inflammation
Vibrio cholerae-Induced Inflammation in the Neonatal Mouse Cholera Model
Anne L. Bishop, Bharathi Patimalla, Andrew Camilli
Host Response and Inflammation
Identification of Early Interactions between Francisella and the Host
Lydia M. Roberts, Shraddha Tuladhar, Shaun P. Steele, Kristina J. Riebe, Ching-ju Chen, R. Ian Cumming, Sarah Seay, Richard Frothingham, Gregory D. Sempowski, Thomas H. Kawula, Jeffrey A. Frelinger
Host Response and Inflammation
In Vivo Splenic Clearance Correlates with In Vitro Deformability of Red Blood Cells from Plasmodium yoelii-Infected Mice
Sha Huang, Anburaj Amaladoss, Min Liu, Huichao Chen, Rou Zhang, Peter R. Preiser, Ming Dao, Jongyoon Han
Host Response and Inflammation
The Tick Salivary Protein Sialostatin L2 Inhibits Caspase-1-Mediated Inflammation during Anaplasma phagocytophilum Infection
Gang Chen, Xiaowei Wang, Maiara S. Severo, Olivia S. Sakhon, Mohammad Sohail, Lindsey J. Brown, Mayukh Sircar, Greg A. Snyder, Eric J. Sundberg, Tyler K. Ulland, Alicia K. Olivier, John F. Andersen, Yi Zhou, Guo-Ping Shi, Fayyaz S. Sutterwala, Michail Kotsyfakis, Joao H. F. Pedra
Host Response and Inflammation
Inhibition of the Alternative Pathway of Nonhuman Infant Complement by Porin B2 Contributes to Virulence of Neisseria meningitidis in the Infant Rat Model
Lisa A. Lewis, David M. Vu, Dan M. Granoff, Sanjay Ram
Host Response and Inflammation
CD11b⁺ Ly6C^hi Ly6G⁻ Immature Myeloid Cells Recruited in Response to Salmonella enterica Serovar Typhimurium Infection Exhibit Protective and Immunosuppressive Properties
Jason W. Tam, Amy L. Kullas, Patricio Mena, James B. Bliska, Adrianus W. M. van der Velden

Fungal and Parasitic Infections

Fungal and Parasitic Infections
Novel Pneumocystis Antigen Discovery Using Fungal Surface Proteomics
Mingquan Zheng, Yang Cai, Taylor Eddens, David M. Ricks, Jay K. Kolls
Fungal and Parasitic Infections
Functional Antibodies against VAR2CSA in Nonpregnant Populations from Colombia Exposed to Plasmodium falciparum and Plasmodium vivax
Sedami Gnidehou, Justin Doritchamou, Eliana M. Arango, Ana Cabrera, Maria Isabel Arroyo, Kevin C. Kain, Nicaise Tuikue Ndam, Amanda Maestre, Stephanie K. Yanow
Fungal and Parasitic Infections
Immunosuppressive Compounds Exhibit Particular Effects on Functional Properties of Human Anti-Aspergillus T_H1 Cells
Lars Tramsen, Stanislaw Schmidt, Frauke Roeger, Ralf Schubert, Emilia Salzmann-Manrique, Jean-Paul Latgé, Thomas Klingebiel, Thomas Lehrnbecher

Microbial Immunity and Vaccines

Microbial Immunity and Vaccines
Vaccination with a Single CD4 T Cell Peptide Epitope from a Salmonella Type III-Secreted Effector Protein Provides Protection against Lethal Infection
Jonathan R Kurtz, Hailey E. Petersen, Daniel R. Frederick, Lisa A. Morici, James B. McLachlan

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Table of Contents

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Commentary

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Molecular Pathogenesis

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Bacterial Infections

Host Response and Inflammation

Fungal and Parasitic Infections

Microbial Immunity and Vaccines

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