Infection and Immunity: 83 (4)

April 1, 2015; Volume 83,Issue 4

Editorial

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Editorial
Competitive Science: Is Competition Ruining Science?
Ferric C. Fang, Arturo Casadevall

Spotlight

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Spotlight
Articles of Significant Interest Selected from This Issue by the Editors

Molecular Pathogenesis

Molecular Pathogenesis
Resistance of Neisseria meningitidis to Human Serum Depends on T and B Cell Stimulating Protein B
Maike G. Müller, Nina E. Moe, Phillip Q. Richards, Gregory R. Moe
Molecular Pathogenesis
Global Analysis of Posttranscriptional Regulation by GlmY and GlmZ in Enterohemorrhagic Escherichia coli O157:H7
Charley C. Gruber, Vanessa Sperandio
Molecular Pathogenesis
Combinational Deletion of Three Membrane Protein-Encoding Genes Highly Attenuates Yersinia pestis while Retaining Immunogenicity in a Mouse Model of Pneumonic Plague
Bethany L. Tiner, Jian Sha, Michelle L. Kirtley, Tatiana E. Erova, Vsevolod L. Popov, Wallace B. Baze, Christina J. van Lier, Duraisamy Ponnusamy, Jourdan A. Andersson, Vladimir L. Motin, Sadhana Chauhan, Ashok K. Chopra
Molecular Pathogenesis
Type IV Pilus Glycosylation Mediates Resistance of Pseudomonas aeruginosa to Opsonic Activities of the Pulmonary Surfactant Protein A
Rommel M. Tan, Zhizhou Kuang, Yonghua Hao, Francis Lee, Timothy Lee, Ryan J. Lee, Gee W. Lau
Molecular Pathogenesis
Role of the Carboxy Terminus of SecA in Iron Acquisition, Protein Translocation, and Virulence of the Bacterial Pathogen Acinetobacter baumannii
Steven E. Fiester, Chika C. Nwugo, William F. Penwell, John M. Neary, Amber C. Beckett, Brock A. Arivett, Robert E. Schmidt, Sarah C. Geiger, Pamela L. Connerly, Sharon M. Menke, Andrew P. Tomaras, Luis A. Actis
Molecular Pathogenesis
Evolutionary Adaptation of an AraC-Like Regulatory Protein in Citrobacter rodentium and Escherichia Species
Aimee Tan, Nicola K. Petty, Dianna Hocking, Vicki Bennett-Wood, Matthew Wakefield, Judyta Praszkier, Marija Tauschek, Ji Yang, Roy Robins-Browne
Molecular Pathogenesis
Novel Aggregative Adherence Fimbria Variant of Enteroaggregative Escherichia coli
Rie Jønsson, Carsten Struve, Nadia Boisen, Ramona Valentina Mateiu, Araceli E. Santiago, Håvard Jenssen, James P. Nataro, Karen A. Krogfelt
Molecular Pathogenesis
Identification and Characterization of Clostridium perfringens Beta Toxin Variants with Differing Trypsin Sensitivity and In Vitro Cytotoxicity Activity
James R. Theoret, Francisco A. Uzal, Bruce A. McClane
Molecular Pathogenesis
Modification of the CpsA Protein Reveals a Role in Alteration of the Streptococcus agalactiae Cell Envelope
Hannah M. Rowe, Brett R. Hanson, Donna L. Runft, Qian Lin, Steve M. Firestine, Melody N. Neely
Molecular Pathogenesis
Protein A Is Released into the Staphylococcus aureus Culture Supernatant with an Unprocessed Sorting Signal
Dara P. O'Halloran, Kieran Wynne, Joan A. Geoghegan
Molecular Pathogenesis
Characterization of a Novel Two-Component Regulatory System, HptRS, the Regulator for the Hexose Phosphate Transport System in Staphylococcus aureus
Joo Youn Park, Jong Wan Kim, Bo Youn Moon, Juyeun Lee, Ye Ji Fortin, Frank W. Austin, Soo-Jin Yang, Keun Seok Seo
Molecular Pathogenesis
Identification and Functional Characterization of the Novel Edwardsiella tarda Effector EseJ
Hai-Xia Xie, Jin-Fang Lu, Ying Zhou, Jia Yi, Xiu-Jun Yu, Ka Yin Leung, Pin Nie

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Mutant Brucella abortus Membrane Fusogenic Protein Induces Protection against Challenge Infection in Mice
Job Alves de Souza Filho, Vicente de Paulo Martins, Priscila Carneiro Campos, Juliana Alves-Silva, Nathalia V. Santos, Fernanda Souza de Oliveira, Gustavo B. Menezes, Vasco Azevedo, Silvio Lorenzo Cravero, Sergio Costa Oliveira
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
The C-Terminal Heavy-Chain Domain of Botulinum Neurotoxin A Is Not the Only Site That Binds Neurons, as the N-Terminal Heavy-Chain Domain Also Plays a Very Active Role in Toxin-Cell Binding and Interactions
B. Vijayalakshmi Ayyar, K. Roger Aoki, M. Zouhair Atassi
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Activates the NLRP3 Inflammasome in Human Macrophages, Leading to the Release of Proinflammatory Cytokines
Bruce J. Shenker, David M. Ojcius, Lisa P. Walker, Ali Zekavat, Monika Damek Scuron, Kathleen Boesze-Battaglia
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
The N Terminus of Type III Secretion Needle Protein YscF from Yersinia pestis Functions To Modulate Innate Immune Responses
Patrick Osei-Owusu, Danielle L. Jessen Condry, Melody Toosky, William Roughead, David S. Bradley, Matthew L. Nilles
Open Access

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Rab14 Regulates Maturation of Macrophage Phagosomes Containing the Fungal Pathogen Candida albicans and Outcome of the Host-Pathogen Interaction
Blessing Okai, Natalie Lyall, Neil A. R. Gow, Judith M. Bain, Lars-Peter Erwig
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
The Flagellar Regulator TviA Reduces Pyroptosis by Salmonella enterica Serovar Typhi
Sebastian E. Winter, Maria G. Winter, Vidya Atluri, Victor Poon, Everton L. Romão, Renée M. Tsolis, Andreas J. Bäumler
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
The Class II Phosphatidylinositol 3-Phosphate Kinase PIK3C2A Promotes Shigella flexneri Dissemination through Formation of Vacuole-Like Protrusions
Ana-Maria Dragoi, Hervé Agaisse

Bacterial Infections

Bacterial Infections
A Small Molecule, Odanacatib, Inhibits Inflammation and Bone Loss Caused by Endodontic Disease
Liang Hao, Wei Chen, Matthew McConnell, Zheng Zhu, Sheng Li, Michael Reddy, Paul D. Eleazer, Min Wang, Yi-Ping Li
Bacterial Infections
Photobacterium damselae subsp. damselae Major Virulence Factors Dly, Plasmid-Encoded HlyA, and Chromosome-Encoded HlyA Are Secreted via the Type II Secretion System
Amable J. Rivas, Ana Vences, Matthias Husmann, Manuel L. Lemos, Carlos R. Osorio
Bacterial Infections
Burkholderia pseudomallei Type III Secretion System Cluster 3 ATPase BsaS, a Chemotherapeutic Target for Small-Molecule ATPase Inhibitors
Lan Gong, Shu-Chin Lai, Puthayalai Treerat, Mark Prescott, Ben Adler, John D. Boyce, Rodney J. Devenish
Bacterial Infections
Ribonucleotide Reductase NrdR as a Novel Regulator for Motility and Chemotaxis during Adherent-Invasive Escherichia coli Infection
Nicolas Dreux, Maria del Mar Cendra, Sébastien Massier, Arlette Darfeuille-Michaud, Nicolas Barnich, Eduard Torrents
Bacterial Infections
Apparent Role for Borrelia burgdorferi LuxS during Mammalian Infection
William K. Arnold, Christina R. Savage, Alyssa D. Antonicello, Brian Stevenson
Bacterial Infections
Selection for a CEACAM Receptor-Specific Binding Phenotype during Neisseria gonorrhoeae Infection of the Human Genital Tract
Anna Sintsova, Henry Wong, Kelly S. MacDonald, Rupert Kaul, Mumtaz Virji, Scott D. Gray-Owen
Bacterial Infections
Blocking Yersiniabactin Import Attenuates Extraintestinal Pathogenic Escherichia coli in Cystitis and Pyelonephritis and Represents a Novel Target To Prevent Urinary Tract Infection
Ariel R. Brumbaugh, Sara N. Smith, Sargurunathan Subashchandrabose, Stephanie D. Himpsl, Tracy H. Hazen, David A. Rasko, Harry L. T. Mobley
Bacterial Infections
BaeSR, Involved in Envelope Stress Response, Protects against Lysogenic Conversion by Shiga Toxin 2-Encoding Phages
Lejla Imamovic, Alexandre Martínez-Castillo, Carmen Benavides, Maite Muniesa
Bacterial Infections
The Levels of Brachyspira hyodysenteriae Binding to Porcine Colonic Mucins Differ between Individuals, and Binding Is Increased to Mucins from Infected Pigs with De Novo MUC5AC Synthesis
Macarena P. Quintana-Hayashi, Maxime Mahu, Nele De Pauw, Filip Boyen, Frank Pasmans, An Martel, Pushpa Premaratne, Harvey R. Fernandez, Omid Teymournejad, Lien Vande Maele, Freddy Haesebrouck, Sara K. Lindén
Bacterial Infections
The Importance of the Pseudomonas aeruginosa Type III Secretion System in Epithelium Traversal Depends upon Conditions of Host Susceptibility
Aaron B. Sullivan, K. P. Connie Tam, Matteo M. E. Metruccio, David J. Evans, Suzanne M. J. Fleiszig
Bacterial Infections
Role of Copper Efflux in Pneumococcal Pathogenesis and Resistance to Macrophage-Mediated Immune Clearance
Michael D. L. Johnson, Thomas E. Kehl-Fie, Roger Klein, Jacqueline Kelly, Corinna Burnham, Beth Mann, Jason W. Rosch

Host Response and Inflammation

Host Response and Inflammation
MyD88-Dependent Signaling Drives Host Survival and Early Cytokine Production during Histoplasma capsulatum Infection
Alison Coady, Anita Sil
Host Response and Inflammation
The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum
Markus J. T. Ojanen, Hannu Turpeinen, Zuzet M. Cordova, Milka M. Hammarén, Sanna-Kaisa E. Harjula, Mataleena Parikka, Mika Rämet, Marko Pesu
Host Response and Inflammation
Essential Engagement of Toll-Like Receptor 2 in Initiation of Early Protective Th1 Response against Rough Variants of Mycobacterium abscessus
Jong-Seok Kim, Min-Jung Kang, Woo Sik Kim, Seung Jung Han, Hong Min Kim, Ho Won Kim, Kee Woong Kwon, So Jeong Kim, Seung Bin Cha, Seok-Yong Eum, Won-Jung Koh, Sang-Nae Cho, Jong-Hwan Park, Sung Jae Shin
Host Response and Inflammation
Uncoupling of Pro- and Anti-Inflammatory Properties of Staphylococcus aureus
Adam G. Peres, Camille Stegen, Junbin Li, An Qi Xu, Benoit Levast, Michael G. Surette, Benoit Cousineau, Martin Desrosiers, Joaquín Madrenas
Host Response and Inflammation
Toll-Like Receptor 2 (TLR2) and TLR9 Play Opposing Roles in Host Innate Immunity against Salmonella enterica Serovar Typhimurium Infection
Renhui Zhan, Qiuju Han, Cai Zhang, Zhigang Tian, Jian Zhang

Fungal and Parasitic Infections

Open Access

Fungal and Parasitic Infections
Cryptococcal Phospholipase B1 Is Required for Intracellular Proliferation and Control of Titan Cell Morphology during Macrophage Infection
Robert J. Evans, Zhongming Li, William S. Hughes, Julianne T. Djordjevic, Kirsten Nielsen, Robin C. May
Fungal and Parasitic Infections
Interleukin-10 from T Cells, but Not Macrophages and Granulocytes, Is Required for Chronic Disease in Leishmania mexicana Infection
Laurence U. Buxbaum
Fungal and Parasitic Infections
IRGM3 Contributes to Immunopathology and Is Required for Differentiation of Antigen-Specific Effector CD8⁺ T Cells in Experimental Cerebral Malaria
Jintao Guo, James A. McQuillan, Belinda Yau, Gregory S. Tullo, Carole A. Long, Patrick Bertolino, Ben Roediger, Wolfgang Weninger, Gregory A. Taylor, Nicholas H. Hunt, Helen J. Ball, Andrew J. Mitchell
Open Access

Fungal and Parasitic Infections
CD4⁺ T Cell Hyporesponsiveness after Repeated Exposure to Schistosoma mansoni Larvae Is Dependent upon Interleukin-10
Catriona T. Prendergast, David E. Sanin, Peter C. Cook, Adrian P. Mountford
Fungal and Parasitic Infections
Dendritic Cell-Based Immunization Ameliorates Pulmonary Infection with Highly Virulent Cryptococcus gattii
Keigo Ueno, Yuki Kinjo, Yoichiro Okubo, Kyoko Aki, Makoto Urai, Yukihiro Kaneko, Kiminori Shimizu, Dan-Ni Wang, Akiko Okawara, Takuya Nara, Kayo Ohkouchi, Yuki Mizuguchi, Susumu Kawamoto, Katsuhiko Kamei, Hideaki Ohno, Yoshihito Niki, Kazutoshi Shibuya, Yoshitsugu Miyazaki
Open Access

Fungal and Parasitic Infections
Dermatophytes Activate Skin Keratinocytes via Mitogen-Activated Protein Kinase Signaling and Induce Immune Responses
Rebecca R. Achterman, David L. Moyes, Selvam Thavaraj, Adam R. Smith, Kris M. Blair, Theodore C. White, Julian R. Naglik
Fungal and Parasitic Infections
Interaction and Assembly of Two Novel Proteins in the Spore Wall of the Microsporidian Species Nosema bombycis and Their Roles in Adherence to and Infection of Host Cells
Donglin Yang, Guoqing Pan, Xiaoqun Dang, Yawei Shi, Chunfeng Li, Pai Peng, Bo Luo, Maofei Bian, Yue Song, Cheng Ma, Jie Chen, Zhengang Ma, Lina Geng, Zhi Li, Rui Tian, Cuifang Wei, Zeyang Zhou

Microbial Immunity and Vaccines

Microbial Immunity and Vaccines
Binding of Complement Factor H to PorB3 and NspA Enhances Resistance of Neisseria meningitidis to Anti-Factor H Binding Protein Bactericidal Activity
Serena Giuntini, Rolando Pajon, Sanjay Ram, Dan M. Granoff
Microbial Immunity and Vaccines
Antibodies against Hemolysin and Cytotoxic Necrotizing Factor Type 1 (CNF1) Reduce Bladder Inflammation in a Mouse Model of Urinary Tract Infection with Toxigenic Uropathogenic Escherichia coli
Mark A. Smith, Rebecca A. Weingarten, Lisa M. Russo, Christy L. Ventura, Alison D. O'Brien
Microbial Immunity and Vaccines
Rapid Effects of a Protective O-Polysaccharide-Specific Monoclonal IgA on Vibrio cholerae Agglutination, Motility, and Surface Morphology
Kara J. Levinson, Magdia De Jesus, Nicholas J. Mantis

Molecular Genomics

Molecular Genomics
Comparative Genome Sequencing of Rickettsia rickettsii Strains That Differ in Virulence
Tina R. Clark, Nicholas F. Noriea, DeAnna C. Bublitz, Damon W. Ellison, Craig Martens, Erika I. Lutter, Ted Hackstadt

Letters to the Editor

Open Access

Letters to the Editor
A Truncation in the Regulator RocA Underlies Heightened Capsule Expression in Serotype M3 Group A Streptococci
N. N. Lynskey, C. E. Turner, Li S. Heng, S. Sriskandan
Free

Letters to the Editor
Reply to “A Truncation in the Regulator RocA Underlies Heightened Capsule Expression in Serotype M3 Group A Streptococci”
Eric W. Miller, Kathryn J. Pflughoeft, Paul Sumby

Retraction

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Retraction
Retraction for Xu et al., Reactive Oxygen Species-Triggered Trophoblast Apoptosis Is Initiated by Endoplasmic Reticulum Stress via Activation of Caspase-12, CHOP, and the JNK Pathway in Toxoplasma gondii Infection in Mice
Xiucai Xu, Tingting Liu, Aimei Zhang, Xingxing Huo, Qingli Luo, Zhaowu Chen, Li Yu, Qing Li, Lili Liu, Zhao-rong Lun, Jilong Shen

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Table of Contents

Editorial

Spotlight

Molecular Pathogenesis

Cellular Microbiology: Pathogen-Host Cell Molecular Interactions

Bacterial Infections

Host Response and Inflammation

Fungal and Parasitic Infections

Microbial Immunity and Vaccines

Molecular Genomics

Letters to the Editor

Retraction

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