Cover photograph (Copyright © 2016, American Society for Microbiology. All Rights Reserved.): Budding cryptococcal yeast cell, stationary in the vasculature of a zebrafish larva as erythrocytes flow past. Cryptococcus cells inoculated into zebrafish larvae are initially taken up by phagocytes but after hours to days are seen intermittently free in the vasculature in small numbers. A cycle of host cell release and recapture maintains this low-level fungemia, which eventually leads to brain invasion. (See related article on page 3047.)